Polylysine and cysteine functionalized chitosan nanoparticle as an efficient platform for oral delivery of paclitaxel

Du, Xiao; Yin, Shaoping; Xu, Linqiang; Ma, Jiqun; Yu, Hua; Wang, Guangji; Li, Juan

doi:10.1016/j.carbpol.2019.115484

Cited by 68 publications

(35 citation statements)

References 47 publications

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“…However, the presence of organic solvents to increase Taxol ® and derivates’ solubility may have adverse effects. Therefore, alternatives have been developed to increase the oral bioavailability, such as formulations with PTX conjugated to chitosan, lipid derivates, nanocochleates, hyaluronic acid-octadecylamine micelles, and oil-based nanocarriers [ 54 , 86 , 87 , 88 , 89 , 90 , 91 ]. PTX loaded in milk-derived exosomes has also shown a high oral bioavailability and low toxicity as a system to maximize oral chemotherapy [ 92 ].…”

Section: Introductionmentioning

confidence: 99%

A Compressive Review about Taxol®: History and Future Challenges

et al. 2020

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Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to treat over one million patients, making it one of the most widely employed antitumoral drugs. Taxol® was the first microtubule targeting agent described in the literature, with its main mechanism of action consisting of the disruption of microtubule dynamics, thus inducing mitotic arrest and cell death. However, secondary mechanisms for achieving apoptosis have also been demonstrated. Despite its wide use, Taxol® has certain disadvantages. The main challenges facing Taxol® are the need to find an environmentally sustainable production method based on the use of microorganisms, increase its bioavailability without exerting adverse effects on the health of patients and minimize the resistance presented by a high percentage of cells treated with paclitaxel. This review details, in a succinct manner, the main aspects of this important drug, from its discovery to the present day. We highlight the main challenges that must be faced in the coming years, in order to increase the effectiveness of Taxol® as an anticancer agent.

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Section: Introductionmentioning

confidence: 99%

A Compressive Review about Taxol®: History and Future Challenges

et al. 2020

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“…Regarding bioavailability, in pharmacological studies, compound 9 was five times more bioavailable than in Taxol ® formulation. In addition, lower toxicity and better distribution of this way administered compound 9 in tumors in mouse models compared to Taxol ® was confirmed [ 49 ].…”

Section: Microtubule Inhibitorsmentioning

confidence: 96%

Mitotic Poisons in Research and Medicine

et al. 2020

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Cancer is one of the greatest challenges of the modern medicine. Although much effort has been made in the development of novel cancer therapeutics, it still remains one of the most common causes of human death in the world, mainly in low and middle-income countries. According to the World Health Organization (WHO), cancer treatment services are not available in more then 70% of low-income countries (90% of high-income countries have them available), and also approximately 70% of cancer deaths are reported in low-income countries. Various approaches on how to combat cancer diseases have since been described, targeting cell division being among them. The so-called mitotic poisons are one of the cornerstones in cancer therapies. The idea that cancer cells usually divide almost uncontrolled and far more rapidly than normal cells have led us to think about such compounds that would take advantage of this difference and target the division of such cells. Many groups of such compounds with different modes of action have been reported so far. In this review article, the main approaches on how to target cancer cell mitosis are described, involving microtubule inhibition, targeting aurora and polo-like kinases and kinesins inhibition. The main representatives of all groups of compounds are discussed and attention has also been paid to the presence and future of the clinical use of these compounds as well as their novel derivatives, reviewing the finished and ongoing clinical trials.

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“…The interactions with functional head groups on polysaccharides enables the incorporation of therapeutic drugs into the main chain through covalent bonds or electrostatic interactions followed by subsequent release of the incorporated drug at target site under a suitable stimuli [31,32]. Similarly, the amphiphilic derivatives of polysaccharides prepared by tethering the hydrophobic moieties to the parent chain possess self-assembly properties in physiological settings and present applications for the delivery of hydrophobic drug molecules such as paclitaxel to the target cells [33][34][35][36].…”

Section: Physicochemical Factorsmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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Polylysine and cysteine functionalized chitosan nanoparticle as an efficient platform for oral delivery of paclitaxel

Cited by 68 publications

References 47 publications

A Compressive Review about Taxol®: History and Future Challenges

A Compressive Review about Taxol®: History and Future Challenges

Mitotic Poisons in Research and Medicine

Current-status and applications of polysaccharides in drug delivery systems

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