Polymer architecture as key to unprecedented high-resolution 3D-printing performance: The case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone

Arslan, Aysu; Steiger, W.; Roose, Patrice; Bergen, Hugues Van den; Gruber, Peter; Zerobin, Elise; Gantner, Franziska; Guillaume, Olivier; Ovsianikov, Aleksandr; Vlierberghe, Sandra Van; Dubruel, Peter

doi:10.1016/j.mattod.2020.10.005

Cited by 39 publications

(49 citation statements)

References 84 publications

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“…As expected, compared to reported data on the storage modulus of a PCL-based AUP with a higher MM of 2000 g mol −1 (i.e. G′ = 0.7 MPa), AUP530 showed a higher storage modulus [ 37 ]. As shown in Table 2 , AUP530 (100 wt%) showed a significantly higher viscosity (i.e.…”

Section: Discussionsupporting

confidence: 77%

Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair

Pien

Maele²,

Parmentier³

et al. 2022

J Mater Sci: Mater Med

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Hand tendon injuries represent a major clinical problem and might dramatically diminish a patient’s life quality. In this study, a targeted solution for flexor tendon repair was developed by combining a mechanical and biological approach. To this end, a novel acrylate-endcapped urethane-based polymer (AUP) was synthesized and its physico-chemical properties were characterized. Next, tubular repair constructs were developed using electrospinning of the AUP material with incorporated naproxen and hyaluronic acid (i.e. anti-inflammatory and anti-adhesion compounds, respectively), and with a tubular braid as mechanical reinforcement. Tensile testing of the repair constructs using ex vivo sheep tendons showed that the developed repair constructs fulfilled the required mechanical properties for tendon repair (i.e. minimal ultimate stress of 4 MPa), with an ultimate stress of 6.4 ± 0.6 MPa. Moreover, in vitro biological assays showed that the developed repair tubes and the incorporated bioactive components were non-cytotoxic. In addition, when equine tenocytes and mesenchymal stem cells were co-cultured with the repair tubes, an increased production of collagen and non-collagenous proteins was observed. In conclusion, this novel construct in which a mechanical approach (fulfilling the required mechanical properties) was combined with a biological approach (incorporation of bioactive compounds), shows potential as flexor tendon repair application.

show abstract

Section: Discussionsupporting

confidence: 77%

Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair

Pien

Maele²,

Parmentier³

et al. 2022

J Mater Sci: Mater Med

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show abstract

“…Other suitable techniques that would allow the determination of the MM include (1) gel permeation chromatography (GPC), which are used rather for qualitative than for quantitative analysis [ 43 , 44 ], (2) membrane osmometry [ 44 , 45 ], (3) intrinsic viscosimetry in combination with static/dynamic light scattering (can be further combined with ultracentrifugation) [ [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] ], and (4) a top-down method in proteomics using high resolution mass spectrometry [ 53 , 54 ]. Although all these techniques would allow the determination of the MM, herein, we have selected the most commonly applied methods in the state-of-the-art [ 20 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…hydroxylysine, lysine and ornithine) for functionalization purposes. Moreover, the type of modification, the corresponding crosslinking mechanism along with the crosslinking kinetics influence the processability of biomaterials into scaffolds along with their mechanical and biological properties (including the material's bioactivity) [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomics as a tool to gain next level insights into photo-crosslinkable biopolymer modifications

Pien

Bray

Gheysens

et al. 2022

Bioactive Materials

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“…[ 16,20 ] However, as a result of the radical chain growth photo‐polymerization of acrylates, the obtained photo‐crosslinked networks are typically brittle, as reflected by an elongation at break below 100%. [ 11,16,21,22 ]…”

Section: Introductionmentioning

confidence: 99%

“…[16,20] However, as a result of the radical chain growth photopolymerization of acrylates, the obtained photo-crosslinked networks are typically brittle, as reflected by an elongation at break below 100%. [11,16,21,22] Around the turn of the century, Cramer and Bowman reported on the incorporation of small molecule thiols into the radical chain growth photo-polymerization of acrylates. They illustrated that incorporation of thiols shifts the polymerization mechanism towards a binary system in which the polymerization occurs via a combination of radical chain and step growth polymerization.…”

Section: Introductionmentioning

confidence: 99%

Thiol‐Mediated Chain Transfer as a Tool to Improve the Toughness of Acrylate Photo‐Crosslinked Poly(ε‐caprolactone)

Thijssen

Vlierberghe

2021

Macro Materials & Eng

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Herein, a straightforward approach is reported to obtain photo-crosslinked, bioresorbable poly(𝝐-caprolactone) (PCL) based networks covering a range of mechanical properties (elongation at break from 203 ± 53 up to 707 ± 101% and ultimate strength from 6.8 ± 2.2 to 13.9 ± 1.5 MPa) via alteration of the network topology. Exploiting multifunctional thiols for crosslinking of acrylate-terminated PCL is an effective method to alter the mechanical properties of photo-crosslinked networks due to the chain transferring ability of the thiols. By controlling the thiol to acrylate ratio, the Young's modulus, elongation at break and ultimate strength can be significantly altered. The materials described in this work can be considered potential candidates for light-based 3D-printing and to serve tissue engineering applications.

show abstract

Polymer architecture as key to unprecedented high-resolution 3D-printing performance: The case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone

Cited by 39 publications

References 84 publications

Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair

Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair

Proteomics as a tool to gain next level insights into photo-crosslinkable biopolymer modifications

Thiol‐Mediated Chain Transfer as a Tool to Improve the Toughness of Acrylate Photo‐Crosslinked Poly(ε‐caprolactone)

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