Polymer-based drug delivery systems for anticancer drugs: A systematic review

Salari, Nader; Faraji, Farahnaz; Torghabeh, Fatemeh Mansouri; Faraji, Fatemeh; Mansouri, Kamran; Abam, Farzaneh; Shohaimi, Shamarina; Akbari, Hakimeh; Mohammadi, Masoud

doi:10.1016/j.ctarc.2022.100605

Cited by 30 publications

(13 citation statements)

References 97 publications

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Section: Aim and Scopementioning

confidence: 99%

“…In the past two decades, a significant number of studies describing the general composition and use of PM for drug delivery were published, focusing on developing new experimental techniques. [40][41][42][43][44][45] Nevertheless, there are only a few articles [46][47][48][49] reported on the use of computations to study polymer-based DDS. In this review, we focus on the basic ideas and current breakthroughs in star-PEG for drug delivery through a computational approach.…”

Section: Aim and Scopementioning

confidence: 99%

“…Drugs used in the traditional treatment are unstable, toxic, and have only a short therapeutic effect. Nevertheless, numerous drug compositions have low solubility due to their hydrophobic nature [1,2] . The ultimate therapeutic efficacy of a prescription drug depends solely on the pharmacological properties of a substance and the mechanisms of its release.…”

Section: Introductionmentioning

confidence: 99%

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A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

Udin,

Maarof,

Rahman

2023

ChemistrySelect

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Polymeric micelles (PM) are amphiphilic block copolymers that can form nanoscopic core/shell structures, making them highly effective for drug delivery systems (DDS). Multi‐armed starshaped poly(ethylene glycol) (PEG) polymers, a promising type of PM, provide a regulated release of drugs and can be integrated with numerous endpoints to create multifunctional drug delivery systems capable of transporting a large number of drugs. Star‐PEG polymers can also be cross‐linked to create three dimensional hydrogels with variable functionalities and sizes, increasing blood flow and reducing unanticipated drug release. In this review, we present state‐of‐the‐art computational tools for analyzing drug pharmacokinetic profiles and identifying molecular interactions critical for successful drug encapsulation in star‐PEG PM. By taking into account the features described, academic and industrial researchers can identify novel interrelationships in PM and maximize their capabilities as DDSs for systemic administration, ultimately enhancing the medicinal qualities of drug delivery.

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Section: Aim and Scopementioning

confidence: 99%

Section: Aim and Scopementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

Udin,

Maarof,

Rahman

2023

ChemistrySelect

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“…In their study, 71 papers were investigated, and they conclude that the polymeric nanoparticles have influential roles in cancer treatment comparing to the conventional chemotherapy. Polymeric nanoparticles were able to reduce the cytotoxicity following chemotherapy drug administration, enhance therapeutic agents solubility, and inhibit tumor growth rate [ 80 ].…”

Section: Polymers As Drug Carriersmentioning

confidence: 99%

Role of Polymers in Microfluidic Devices

et al. 2022

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Polymers are sustainable and renewable materials that are in high demand due to their excellent properties. Natural and synthetic polymers with high flexibility, good biocompatibility, good degradation rate, and stiffness are widely used for various applications, such as tissue engineering, drug delivery, and microfluidic chip fabrication. Indeed, recent advances in microfluidic technology allow the fabrication of polymeric matrix to construct microfluidic scaffolds for tissue engineering and to set up a well-controlled microenvironment for manipulating fluids and particles. In this review, polymers as materials for the fabrication of microfluidic chips have been highlighted. Successful models exploiting polymers in microfluidic devices to generate uniform particles as drug vehicles or artificial cells have been also discussed. Additionally, using polymers as bioink for 3D printing or as a matrix to functionalize the sensing surface in microfluidic devices has also been mentioned. The rapid progress made in the combination of polymers and microfluidics presents a low-cost, reproducible, and scalable approach for a promising future in the manufacturing of biomimetic scaffolds for tissue engineering.

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“…It is an essential technology used to selectively deliver a drug according to the site of the disease or to release the drug periodically while controlling the released amount. However, the effectiveness of these systems is still not satisfactory for clinical applications [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Several studies have been conducted to create micro- or nanosized ultrafine structures, based on micro- and nanotechnologies, to deliver cancer-killing drugs to cancer cells [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

5-Fluorouracil-Immobilized Hyaluronic Acid Hydrogel Arrays on an Electrospun Bilayer Membrane as a Drug Patch

Lee

Kim

et al. 2022

Bioengineering

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The hyaluronic acid (HA) hydrogel array was employed for immobilization of 5-fluorouracil (5-FU), and the electrospun bilayer (hydrophilic: polyurethane/pluronic F-127 and hydrophobic: polyurethane) membrane was used to support the HA hydrogel array as a patch. To visualize the drug propagating phenomenon into tissues, we experimentally investigated how FITC-BSA diffused into the tissue by applying hydrogel patches to porcine tissue samples. The diffusive phenomenon basically depends on the FITC-BSA diffusion coefficient in the hydrogel, and the degree of diffusion of FITC-BSA may be affected by the concentration of HA hydrogel, which demonstrates that the high density of HA hydrogel inhibits the diffusive FITC-BSA migration toward the low concentration region. YD-10B cells were employed to investigate the release of 5-FU from the HA array on the bilayer membrane. In the control group, YD-10B cell viability was over 98% after 3 days. However, in the 5-FU-immobilized HA hydrogel array, most of the YD-10B cells were not attached to the bilayer membrane used as a scaffold. These results suggest that 5-FU was locally released and initiated the death of the YD-10B cells. Our results show that 5-FU immobilized on HA arrays significantly reduces YD-10B cell adhesion and proliferation, affecting cells even early in the cell culture. Our results suggest that when 5-FU is immobilized in the HA hydrogel array on the bilayer membrane as a drug patch, it is possible to control the drug concentration, to release it continuously, and that the patch can be applied locally to the targeted tumor site and administer the drug in a time-stable manner. Therefore, the developed bilayer membrane-based HA hydrogel array patch can be considered for sustained release of the drug in biomedical applications.

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Polymer-based drug delivery systems for anticancer drugs: A systematic review

Cited by 30 publications

References 97 publications

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

A Mini‐Review on the Application of Computational Strategies in Multi‐Armed Star‐PEG Polymeric Micelles for Drug Delivery

Role of Polymers in Microfluidic Devices

5-Fluorouracil-Immobilized Hyaluronic Acid Hydrogel Arrays on an Electrospun Bilayer Membrane as a Drug Patch

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