Polymer-based materials modified with magnetite nanoparticles for enrichment of phospholipids

Ten-Doménech, Isabel; Martínez-Pérez-Cejuela, Héctor; Simó‐Alfonso, Ernesto Francisco; Torres-Cartas, Sagrario; Lloret, Susana Meseguer; Herrero‐Martínez, José Manuel

doi:10.1016/j.talanta.2017.12.042

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…Polymer-based nanoparticles (NPs) are highly biocompatible and are commonly used as tools to facilitate drug delivery, having received approval from the US Food and Drug Administration for medical use. [23][24][25][26] NPs have previously been demonstrated to significantly enhance solubility, bioavailability, efficacy, and pharmacokinetic profiles of encapsulated drugs. 27,28 These NPs are also highly multifunctional, less toxic, and less immunogenic as compared to many other drug delivery nanoplatforms.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage

Yang¹,

Han²,

Li³

et al. 2021

IJN

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Background Intracerebral hemorrhage (ICH) is a form of severe stroke, the pathology of which is tied closely to a recently discovered form of programmed cell death known as ferroptosis. Curcumin (Cur) is a common phenolic compound extracted from the rhizome of Curcuma longa capable of hematoma volume and associated neurological damage in the context of ICH. Despite exhibiting therapeutic promise, the efficacy of Cur is challenged by its poor water solubility, limited oral bioavailability and inability to efficiently transit across the physiological barriers. Polymer-based nanoparticles (NPs) have widely been employed to aid in drug delivery efforts owing to their ideal biocompatibility and their ability to improve the bioavailability and pharmacokinetics of specific drugs of interest. Methods In this study, we encapsulated Cur in NPs (Cur-NPs) and explored the effect of these Cur-NPs to enhance Cur delivery both in vitro and in vivo. Furthermore, we evaluated the anti-ferroptosis effect of Cur-NPs in ICH model mice and erastin-treated HT22 murine hippocampal cells. Results The resultant Cur-NPs were spherical and exhibited a particle size of 127.31±2.73 nm, a PDI of 0.21±0.01 and a zeta potential of −0.25±0.02 mV. When applied to Madin Darby canine kidney (MDCK) cells in vitro, these Cur-NPs were nonspecifically internalized via multiple endocytic pathways, with plasma membrane microcapsules and clathrin-mediated uptake being the dominant mechanisms. Within cells, these NPs accumulated in lysosomes, endoplasmic reticulum and mitochondria. Cur-NPs were capable of passing through physiological barriers in a zebrafish model system. When administrated to C57BL/6 mice, they significantly improved Cur delivery to the brain. Most notably, when administered to ICH model mice, Cur-NPs achieved superior therapeutic outcomes relative to other treatments. In a final series of experiments, these Cur-NPs were shown to suppress erastin-induced ferroptosis in HT22 murine hippocampal cells. Conclusion These Cur-NPs represent a promising means of improving Cur delivery to the brain and thereby better treating ICH.

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Section: Introductionmentioning

confidence: 99%

Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage

Yang¹,

Han²,

Li³

et al. 2021

IJN

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“…The first strategy (procedure A) was adapted from a previous work [25]. Thus, the GMA-based monolith in ETFE tubing was modified by pumping through a solution of APTMS in acetone at 60°C (column oven) at 0.05 mL min -1 using an HPLC pump for 2 h. Upon completion of the reaction, the column was washed with ethanol and dried.…”

Section: Immobilization Of Mnps Onto Polymeric Monoliths In Etfe Tubingmentioning

confidence: 99%

Preparation of monolithic polymer-magnetite nanoparticle composites into poly(ethylene-co-tetrafluoroethylene) tubes for uses in micro-bore HPLC separation and extraction of phosphorylated compounds

Torres-Cartas

Lloret

Benito

et al. 2021

Talanta

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“…Polymer Nanoparticles (NPs) are extensively used drug delivery matrix material with good biocompatibility, which have been approved by the US Food and Drug Administration [23,24]. Previous work reported that NPs can improve the efficacy, solubility, bioavailability and pharmacokinetic profiles of drugs [25,26].…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles improved Curcumin brain delivery and its therapeutic efficacy against intracerebral hemorrhage

Yang¹,

Han²,

Li³

et al. 2021

Preprint

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Background: Intracerebral hemorrhage (ICH) is a severe type of stroke. Ferroptosis is a new form of regulated cell death, which plays an indispensable role in the pathological process of ICH. Curcumin (Cur), a widespread phenolic compound, is derived from the rhizome of Curcuma longa. It could attenuate hematoma volume and neurological injury in ICH. Nevertheless, its poor solubility in water, low oral bioavailability and difficulty in transporting across physiological barriers led to poor efficacy. Polymer nanoparticles (NPs) are widely used drug delivery matrix material with good biocompatibility, which are reported to improve the bioavailability and pharmacokinetic profiles of drugs. In this study, we utilized NPs to encapsulate Cur and analyzed the effect of Cur-NPs on Cur brain delivery and its therapeutic efficacy against ICH. Results: The spherical Cur-NPs had a particle size 127.31±2.73 nm, a PDI of 0.21±0.01 and a zeta potential of -0.25±0.02 mV. Cur-NPs could draw into Madin-Darby canine kidney (MDCK) cells through a number of nonspecific endocytosis mechanisms, mainly mediated via clathrin and plasma membrane microcapsules. Moreover, Cur-NPs tended to accumulate in the endoplasmic reticulum and lysosome. In a zebrafish model, Cur-NPs could transport across physiological barriers. In a C57BL/6 mice model, we found that Cur-NPs had more desirable improvements in Cur accumulation within the plasma and brain. Importantly, in an ICH mouse model, we confirmed that Cur-NPs were an effective treatment for ICH. Finally, Cur-NPs effectively inhibited ferroptosis caused by erastin in HT22 mouse hippocampal cells. Conclusion: Cur-NPs represent a potentially effective strategy to enhance Cur brain delivery and therapeutic efficacy in the treatment of ICH.

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Polymer-based materials modified with magnetite nanoparticles for enrichment of phospholipids

Cited by 7 publications

References 44 publications

Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage

Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage

Preparation of monolithic polymer-magnetite nanoparticle composites into poly(ethylene-co-tetrafluoroethylene) tubes for uses in micro-bore HPLC separation and extraction of phosphorylated compounds

Polymeric nanoparticles improved Curcumin brain delivery and its therapeutic efficacy against intracerebral hemorrhage

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