Polymer-based Therapies for Posterior Segment Ocular Disease

Hirani, Anjali; Grover, Aditya

doi:10.4172/2167-7956.1000e122

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…For any drug delivery system therapy to be effective, the drug delivery system must fulfill three major goals: (1) drug release must be targeted; (2) drug release should be controlled; and (3) the drug should maintain therapeutic efficacy at adequate dose levels. 58 Researchers have developed formulations for glaucoma treatment using natural polymers, including polysaccharide-based polymers. By prolonging and sustaining the pharmacological activity of drug molecules, these systems could be able to reduce the need for frequent medical interventions, thus minimizing side effects.…”

Section: Polysaccharide-based Formulations For Glaucoma Treatmentmentioning

confidence: 99%

Polysaccharides polymers for glaucoma treatment-a review

Ahmed,

Islam,

Monalisa

et al. 2023

European Journal of Ophthalmology

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One of the major challenges in preventing glaucoma progression is patient compliance with medication regimens. Since conventional ophthalmic dosage forms have numerous limitations, researchers have been intensively working on developing polymers-based delivery systems for glaucoma drugs. Specifically, research and development efforts have increased using polysaccharide polymers such as sodium alginate, cellulose, β-cyclodextrin, hyaluronic acid, chitosan, pectin, gellan gum, galactomannans for sustained release to the eye to overcome treatment challenges, showing promise in improving drug release and delivery, patient experience, and treatment compliance. In the recent past, multiple research groups have successfully designed sustained drug delivery systems, promoting the efficacy as well as the feasibility of glaucoma drugs with single/combinations of polysaccharides to eliminate the drawbacks associated with the glaucoma treatment. Naturally available polysaccharides, when used as drug vehicles can increase the retention time of eye drops on the ocular surface, leading to improved drug absorption and bioavailability. Additionally, some polysaccharides can form gels or matrices that can release drugs slowly over time, providing sustained drug delivery and reducing the need for frequent dosing. Thus, this review aims to provide an overview of the pre-clinical and clinical studies of polysaccharide polymers applied for glaucoma treatment along with their therapeutic outcomes.

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Section: Polysaccharide-based Formulations For Glaucoma Treatmentmentioning

confidence: 99%

Polysaccharides polymers for glaucoma treatment-a review

Ahmed,

Islam,

Monalisa

et al. 2023

European Journal of Ophthalmology

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“…This is mainly due to their ability to swell in an aqueous solvent platform, thus, retaining solvents within a cross-linked gel network, along with other hydrophobic and hydrophilic agents, small molecules and macromolecules [42]. They can also combine with micro-or nanomaterials to enhance ODD, regardless of their solubility characteristics [47].…”

Section: Hydrogel Soft Contact Lensmentioning

confidence: 99%

Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards

Nguyen

Dowling²,

Ryan

et al. 2021

Contact Lens and Anterior Eye

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Therapeutic contact lenses for ocular drug delivery have received considerable interest as they can potentially enhance ocular bioavailability, increase patient compliance, and reduce side effects. Along with the successful in vitro and in vivo studies on sustained drug delivery through contact lenses, lens critical properties such as water content, optical transparency and modulus have also been investigated. Aside from issues such as drug stability or burst release, the potential for the commercialization of pharmaceutical-loaded lenses can be limited by the alteration of lens physical and chemical properties upon the incorporation of therapeutic or non-therapeutic components.This review outlines advances in the use of pharmaceutical-loaded contact lenses and their relevant characterization methodologies as a potential ocular drug delivery system from 2010 to 2020, while summarizing current gaps and challenges in this field. A key reference point for this review is the relevant ISO standards on contact lenses, relating to the associated characterization methodologies. The content of this review is categorized based on the chemical, physical and mechanical properties of the loaded lens with the shortcomings of such analytical technologies examined.

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“…During embryological development, the eye is derived from the fore-brain giving it a blood-retina barrier that is structurally similar to the blood-brain barrier [1]. Although treatment to diseases affecting the anterior segment of the eye are administered through topical application, the posterior segment of the eye consists of several barriers as well as mechanisms of clearance that inhibit therapeutic access and show poor bioavailability due to systemic absorption [2]. The posterior segment of the eye is composed of the vitreous humour, retina, and choroid ( Figure 1) [2].…”

Section: Editorialmentioning

confidence: 99%

“…Although treatment to diseases affecting the anterior segment of the eye are administered through topical application, the posterior segment of the eye consists of several barriers as well as mechanisms of clearance that inhibit therapeutic access and show poor bioavailability due to systemic absorption [2]. The posterior segment of the eye is composed of the vitreous humour, retina, and choroid ( Figure 1) [2]. Ocular disease in this segment has been found to be the most predominant causes of visual damage and/or deficiency today and affects an estimated 1.75 million people in the United States today [3,4].…”

Section: Editorialmentioning

confidence: 99%