Polymer-Caged Lipsomes:  A pH-Responsive Delivery System with High Stability

Lee, Sang Min; Chen, Haimei; Dettmer, Christine M.; O’Halloran, Thomas V.; Nguyen, SonBinh T.

doi:10.1021/ja070748i

Cited by 233 publications

(244 citation statements)

References 21 publications

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“…Passive targeting employs polymeric structures as carriers, such as nanoparticles, polymers, or liposomes. [284][285][286][287][288][289][290][291] This strategy is highly dependent on the enhanced permeability and retention effect. The direct conjugation of a chemotherapeutic drug to a certain tumor cell targeting ligand represents active targeting.…”

Section: Challenges and Perspectives For Optical Chemical Probesmentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.

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Section: Challenges and Perspectives For Optical Chemical Probesmentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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“…Traditionally drugs in photothermal therapies are delivered via polymeric structures or liposomes [99,[227][228][229][230][231][232]. However, these delivery agents are hindered by several factors.…”

Section: Multi-modal Treatmentsmentioning

confidence: 99%

“…However, these delivery agents are hindered by several factors. Polymers are cytotoxic and degrade in vivo, promoting immunogenic reactions, and liposomes are prone to leakage which results in decreased efficiency of biomolecule delivery [231,[233][234][235][236][237].…”

Section: Multi-modal Treatmentsmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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“…However, these bilayer and acyl‐chain lipid products have not fulfilled their practical potential due to their insufficient morphological stability and inclusion leakage in vitro and in vivo 9. To address these drawbacks, various optimizations have been approached,10 which include surface coating with certain amphiphilic molecules (PEGylation; where PEG is polyethylene glycol) and cholesterols for prolonging circulation,11 enhancing elasticity using transferosome formulations for transdermal delivery,12 and improving bioavailability that employ drug–lipid conjugates 13. Although these strategies have significantly promoted the therapeutic potential of traditional lipid nanoparticles with increasingly broad applications, several concerns such as insufficient coverage of surface coating on phospholipid bilayers,14 and the morphological stability of lipid assemblies are likely to decrease after modulating composition, charge, and bilayer architecture.…”

Section: Introductionmentioning

confidence: 99%

Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies

Wang

et al. 2018

Advanced Science

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Bioinspired lipid assemblies that mimic the elaborate architecture of natural membranes have fascinated researchers for a long time. These lipid assemblies have gone from being just an imperative platform for biophysical research to a pharmaceutical delivery system for biomedical applications. Despite success, these organized nanosystems are often subject to the mechanical instability and limited theranostic capability without adding any inconvenient modifications. To reach their advanced pharmaceutical potential, various bioinorganic hybrid lipid‐based assembles, which provide new opportunities to synergistically complement and improve therapeutic/diagnostic potential of existing lipid‐based nanomedicine with distinct mechanisms containing inorganic embedded surfactants, have recently been developed.

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Polymer-Caged Lipsomes: A pH-Responsive Delivery System with High Stability

Cited by 233 publications

References 21 publications

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies

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