Polymer- coated magnetic nanoparticles formulation enhanced blood-stage Malaria DNA vaccine delivery with the best PEI/Fe ratio
Abstract:Superparamagnetic nanoparticles SPIONs with specific sizes and surface characteristics can promote potent immune responses against different parasitic infection by enhancing antigen uptake of proper immune-stimulatory cell types. Magnetite (Fe 3 O 4) nanoparticles have shown many potential bio-applications due to their biocompatibility and special characteristics. The use of Polyethylenimine (PEI) polymer-coated superparamagnetic nanoparticles (SPIONs) to deliver malaria genes via magnetofection shows promise … Show more
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