Polymer-Coated Polymeric (PCP) Microneedles for Controlled Dermal Delivery of 5-Fluorouracil

Matadh, Anusha V; Jakka, Deeksha; Pragathi, S G; Rangappa, Srinath; Shivakumar, H.N.; Maibach, Howard; Reena, N. M.; Murthy, S. N. B.

doi:10.1208/s12249-022-02471-x

Cited by 11 publications

(3 citation statements)

References 27 publications

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“…Coating of microneedles is commonly performed by dip coating, 79 spin coating, 80 and electrodeposition. 28 These processes create a thin film in the surfaces to impart specific properties or functionalities.…”

Section: Types Of Microneedles For Monitoring Approaches and Their Ma...mentioning

confidence: 99%

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Pereira,

Vinayakumar,

Sillankorva

2024

ACS Sens.

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Bioanalyte collection by blood draw is a painful process, prone to needle phobia and injuries. Microneedles can be engineered to penetrate the epidermal skin barrier and collect analytes from the interstitial fluid, arising as a safe, painless, and effective alternative to hypodermic needles. Although there are plenty of reviews on the various types of microneedles and their use as drug delivery systems, there is a lack of systematization on the application of polymeric microneedles for diagnosis. In this review, we focus on the current state of the art of this field, while providing information on safety, preclinical and clinical trials, and market distribution, to outline what we believe will be the future of health monitoring.

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Section: Types Of Microneedles For Monitoring Approaches and Their Ma...mentioning

confidence: 99%

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Pereira,

Vinayakumar,

Sillankorva

2024

ACS Sens.

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“…The polymer coating prolonged the drug release by 3 h. Then, 5-FU was loaded in the core of the MNs and further coated with polymer to prolong the drug release. This polymeric-MN-based controlled delivery of 5-FU in the sub-stratum corneum is useful in the treatment of melanoma [119].…”

Section: Demartis Et Al Demonstrated the Fabrication Of Dissolving Mn...mentioning

confidence: 99%

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Kulkarni,

Gadade,

Chapaitkar

et al. 2023

Sci. Pharm.

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Microneedles are gaining popularity as a new paradigm in the area of transdermal drug delivery for biomedical and healthcare applications. Efficient drug delivery with minimal invasion is the prime advantage of microneedles. The concept of the microneedle array provides an extensive surface area for efficient drug delivery. Various types of inorganics (silicon, ceramic, metal, etc.) and polymeric materials are used for the fabrication of microneedles. The polymeric microneedles have various advantages over other microneedles fabricated using inorganic material, such as biocompatibility, biodegradation, and non-toxicity. The wide variety of polymers used in microneedle fabrication can provide a broad scope for drug delivery and other biomedical applications. Multiple metallic and polymeric microneedles can be functionalized by polymer coatings for various biomedical applications. The fabrication of polymeric microneedles is shifting from conventional to advanced 3D and 4D printing technology. The multifaceted biomedical applications of polymeric microneedles include drug delivery, vaccine delivery, biosensing, and diagnostic applications. Here, we provide the overview of the current and advanced information on polymers used for fabrication, the selection criteria for polymers, biomedical applications, and the regulatory perspective of polymer-based and polymer-coated microneedles, along with a patent scenario.

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“…An increasing area of interest in TDD is the use of microneedle arrays (MNs), also known as microarray patches, to mechanically breach the SC, epidermis and supercial dermis, therefore bypassing the skin's natural barrier function. [22][23][24][25] A number of different MN technologies exist including hollow, [26][27][28] coated, 29,30 dissolving, 31,32 hydrogel forming, 33,34 and solid MNs. [35][36][37][38] Solid MNs consist of sub-millimetre protrusions usually fabricated from metal or silicon.…”

Section: Introductionmentioning

confidence: 99%

Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Morris,

Long,

Savage

et al. 2023

Nanoscale Adv.

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Polymer-Coated Polymeric (PCP) Microneedles for Controlled Dermal Delivery of 5-Fluorouracil

Cited by 11 publications

References 27 publications

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

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Polymer-Coated Polymeric (PCP) Microneedles for Controlled Dermal Delivery of 5-Fluorouracil

Cited by 11 publications

References 27 publications

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Polymeric Microneedles for Health Care Monitoring: An Emerging Trend

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

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Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration