Polymer complexes. LXXVII. Synthesis, characterization, spectroscopic studies and immune response in cattle of quinoline polymer complexes

Abstract

A series of novel polymeric metal complexes of Co(II), Ni(II), Cu(II), Zn(II) and Cr(III) with 5,5′-{(1E,1E′)-1,4-phenylenebis(diazene-2,1-diyl)} bis(quinolin-8-ol) (H 2 L) ligand were synthesized and characterized using elemental analyses, 1 H NMR, mass, infrared, UV-visible and electron spin resonance (ESR) spectroscopies, magnetic moment and conductivity measurements as well as thermal analyses. The spectral and analytical data revealed the ligand adopted a neutral bidentate fashion when binding to metal ions via the nitrogen of azomethine of pyridine ring and the deprotonated hydroxyl group. Electronic and magnetic susceptibility measurements of the polymer complexes indicated octahedral geometry for all polymer complexes. The ESR spectral data provided information about the structures on the basis of Hamiltonian parameters and the degree of covalency. Molecular docking was used to predict the binding between the H 2 L and the receptor of breast cancer (3hb5). The immune response of the synthesized polymer complexes with bovine respiratory syncytial (BRS) vaccine in cattle was studied using serum neutralizations test (SNT). It was found that the isolated polymer complexes with BRS vaccine caused a significant increase in the antibody titre against BRS virus in SNT compared to BRS vaccine alone.

Polymer complexes. LXXVIII. Synthesis and characterization of supramolecular uranyl polymer complexes: Determination of the bond lengths of uranyl ion in polymer complexes

“…In addition to the data proven that, the HL x ligands (Figure S1 (A) ) are efficient inhibitors of receptors of prostate cancer and breast cancer (1JNX) than tautomeric form (D) of ligands (HL x ). These results are found to be in good agreement with the similar results were obtained recently …”

“…Literature surveys indicate that quinoline derivatives possess diverse pharmacological activities, including anti‐inflammatory, antiviral, antitumor activities antimicrobial and, antibody titer against bovine respiratory syncytial (BRS) virus in serum neutralizations test (SNT) . Also, they have been used in chromatography and for the detection of metal ions, antioxidant and biological effect activities .…”

“…They form very stable chelate rings with metal centers, and very stable complexes with a number of metal ions. The deprotonated oxygen atom and the ring nitrogen atom are involved in the metal chelation …”

Synthesis, characterization, and biological investigation of new mixed‐ligand complexes

“…The chelates were dissolved in DMSO, and the molar conductivities of 10 −3 M solutions at room temperature were measured using the recommended procedure. The low values of molar conductivity of mixedligand complexes (1-4) indicate their nonelectrolytic nature, and no ions are present outside the coordination spheres, [26,27] except mixed-ligand complex (1). The formation of white precipitate when a drop of 0.1 M of AgNO 3 was added to the mixed-ligand complex (1) confirms the presence of chlorine ions in the outer layer of the coordination sphere [1,2] (Table 1).…”

Electrochemical behavior of two dyes as corrosion inhibitors for carbon steel in acid medium and studying their biological activities by practical and theoretical aspects

“…Docking calculations were carried out on the receptor of crystal structure of Staphylococcus aureus (3q8u) and the receptor of crystal structure of Escherichia coli (3t88) proteins model. Essential hydrogen atoms, solvation parameters and Kollman united atom type charges were added with the aid of AutoDock tools [20][21][22][23].…”