Polymer Directed Self-Assembly of pH-Responsive Antioxidant Nanoparticles

Tang, Christina; Amin, Devang; Messersmith, Phillip B.; Anthony, John E.; Prud'homme, Robert Krafft

doi:10.1021/acs.langmuir.5b00213

Cited by 66 publications

(99 citation statements)

References 58 publications

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“…The swelling of the nanoreactors at acidic pH is less than reported for TA/PS-b-PEG without gold 17 . Once assembled, gold-polystyrene interactions i.e.…”

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confidence: 55%

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Efficient preparation of size tunable PEGylated gold nanoparticles

et al. 2016

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A facile, one-step self-assembly of polymer nanoreactors is reported for the fabrication of uniform PEGylated gold nanoparticles. Nanoreactor assembly occurs within milliseconds and gold nanoparticles are produced within minutes at room temperature. The presented approach enables continuous synthesis of size tunable gold nanoparticles with tailorable surface chemistry. Figure 2. (a) Initial nanoreactor size distributions measured by DLS and (b) UV absorbance of the dialyzed dispersions synthesized at a range of pHs by diluting the effluent from the mixer into PBS, pH 7.4, water (MQ) or 0.01M HCl.The nanoreactor assembly occurs on the order of milliseconds (time scale of mixing). The reduction to Au(0) occurs in the nanoreactor where TA is localized. The reduction is evident by the transition from the light amber dispersion to strongly red or purple colored dispersions associated with colloidal gold (Fig. 2, Supporting Information Figure S2) that occurs within ~20 seconds (at pH 6) to ~7 minutes (pH 2). The effect of pH on the rate of reduction has been used to tune nanoparticle size over a relatively narrow range 17-20 nm 20 . We demonstrate this strategy

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“…The swelling of the nanoreactors at acidic pH is less than reported for TA/PS-b-PEG without gold 17 . Once assembled, gold-polystyrene interactions i.e.…”

mentioning

confidence: 55%

“…With TA and no gold chlroide, the nanoreactor size is ~90 nm 17 where aggregates are formed at the initial pH = 2 during mixing. The aggregate size is determined by this initial mixing, and dilution into a larger reservoir at pH 2, 5.5 or 7.4 does not alter that size.…”

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confidence: 99%

Efficient preparation of size tunable PEGylated gold nanoparticles

et al. 2016

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“…Such systems can be used for therapy of cardiovascular diseases (e.g., atherosclerosis) and neurological disorders (e.g., Alzheimer’s). 142 …”

Section: Challenges and Issues In The Design And Use Of Ph-sensitive mentioning

confidence: 99%

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

Karimi

Eslami

Zangabad

et al. 2016

WIREs Nanomed Nanobiotechnol

198

105

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In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual pH-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as Alzheimer’s. In order to design an optimized system, it is necessary to understand the various pH-responsive micro/nanoparticles and the different mechanisms of pH-sensitive drug release. This should be accompanied by an assessment of the theoretical and practical challenges in the design and use of these carriers.

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“…The self-assembly of block-copolymers allows the formation of diverse soft nanoarchitectures, but presents several engineering challenges, namely: loading efficiency, scalability, repeatability and ease of fabrication. Flash nanoprecipitation (FNP) is a fabrication technique capable of addressing the majority of these issues, but has so far only been applied for the formation of solid-core nanoparticles and their loading with hydrophobic drugs [6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation

Allen

Osorio

Liu

et al. 2017

Journal of Controlled Release

141

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Flash nanoprecipitation (FNP) has proven to be a powerful tool for the rapid and scalable assembly of solid-core nanoparticles from block copolymers. The process can be performed using a simple confined impingement jets mixer and provides an efficient and reproducible method of loading micelles with hydrophobic drugs. To date, FNP has not been applied for the fabrication of complex or vesicular nanoarchitectures capable of encapsulating hydrophilic molecules or bioactive protein therapeutics. Here, we present FNP as a single customizable method for the assembly of bicontinuous nanospheres, filomicelles and vesicular, multilamellar and tubular polymersomes from poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers. Multiple impingements of polymersomes assembled via FNP were shown to decrease vesicle diameter and polydispersity, allowing gram-scale fabrication of monodisperse polymersomes within minutes. Furthermore, we demonstrate that FNP supports the simultaneous loading of both hydrophobic and hydrophilic molecules respectively into the polymersome membrane and aqueous lumen, and encapsulated enzymes were found to be released and remain active following vesicle lysis. As an example application, theranostic polymersomes were generated via FNP that were dual loaded with the immunosuppressant rapamycin and a fluorescent dye to link targeted immune cells with the elicited immunomodulation of T cells. By expanding the capabilities of FNP, we present a rapid, scalable and reproducible method of nanofabrication for a wide range of nanoarchitectures that are typically challenging to assemble and load with therapeutics for controlled delivery and theranostic strategies.

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Polymer Directed Self-Assembly of pH-Responsive Antioxidant Nanoparticles

Cited by 66 publications

References 58 publications

Efficient preparation of size tunable PEGylated gold nanoparticles

Efficient preparation of size tunable PEGylated gold nanoparticles

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation

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