Polymer grafted magnetic nanoparticles for delivery of anticancer drug at lower pH and elevated temperature

Dutta, Sujan; Parida, S.C.; Maiti, C. K.; Banerjee, Rakesh; Mandal, Mahitosh; Dhara, Dibakar

doi:10.1016/j.jcis.2016.01.008

Cited by 56 publications

(26 citation statements)

References 48 publications

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“…Negative temperature hydrogels have a lower critical solution temperature (LCST), existing in the shrunken state at temperatures above the LCST and swelling at temperatures below the LCST. Poly N ‐isopropylacrylamide (PNIPA) is a negative temperature hydrogel that has attracted much attention due to the facts its LCST (~33 °C) is very close to human body temperature, making it ideal for drug transport and delivery …”

Section: Introductionmentioning

confidence: 99%

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Zhang

Wang

Waterhouse

et al. 2019

J of Applied Polymer Sci

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Temperature‐sensitive hydrogels are attracting increasing attention for controlled drug delivery. However, achieving high drug loadings and sustained drug release remains challenging. Herein, we describe the successful synthesis of a series of novel temperature‐sensitive poly(N‐isopropylacrylamide) (PNIPA)/mesoporous silica nanoparticles (MSN) hydrogels by physical crosslinking of NIPA with MSN. The external and internal structures, temperature sensitivity, drug‐loading capacity, and blood compatibility of the PNIPA/MSN composite hydrogels are studied. Results show that MSN addition improved the network structure and adjusted the size of the hole, MSN could also act as drug carrier, thereby enhancing the drug loading capacity. The composite hydrogels underwent a phase transition at 33.7 °C (at the lower critical solution temperature). The hemolysis rate of the composite hydrogels was less than 1%, thus they can be classified as a nonhemolytic materials with good biocompatibility. The composite hydrogels reported here thus have great potential in drug transport and temperature‐activated drug release. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48391.

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Section: Introductionmentioning

confidence: 99%

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Zhang

Wang

Waterhouse

et al. 2019

J of Applied Polymer Sci

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“…It behaves as superparamagnetic as the particle size is reduced to a few nanometers. MNPs have been used for biomedical applications such as biosensing, cell tracking, tissue engineering, magnetic resonance imaging (MRI)/optical multimodal imaging, targeted drug delivery, and hyperthermia therapeutic cancer treatment [1][2][3][4][5][6][7][8]. Whereas ferrite system CoFe2−xAlxO4 (x = 0.0, 0.3, 0.7 and 1.0) have been synthesized through the co-precipitation technique to form a nano-size (20-63 nm) single spinel phase [22].…”

Section: Introductionmentioning

confidence: 99%

Environmental implications and applications of engineered nanoscale magnetite and its hybrid nanocomposites: A review of recent literature

2017

Journal of Hazardous Materials

308

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“…In this regard, polymer grafting on inorganic, metal or carbon‐based surfaces, known as polymer brushes, is of particular importance in many fields of application . Polymers tethered to inorganic surfaces like SiO 2 , Fe 3 O 4 , ZnO, Au or alumina have attracted extensive research interest due to the ability to modify the surface characteristics and have applications in basic and applied interfacial studies. One of the most promising support matrices, for incorporation of polymer species, is superparamagnetic iron oxide nanoparticles with high surface area, which are easily obtained from commercially available materials such as FeCl 3 ⋅6H 2 O and FeCl 2 ⋅4H 2 O in water .…”

Section: Introductionmentioning

confidence: 99%

Mizoroki–Heck and Suzuki–Miyaura reactions mediated by poly(2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid)‐stabilized magnetically separable palladium catalyst

Arghan

Koukabi

Kolvari

2018

Applied Organom Chemis

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Funding information Semnan University Research CouncilThe purpose of this work was to synthesize and characterize a new magnetic polymer nanosphere-supported palladium(II) acetate catalyst for reactions requiring harsh conditions. In this regard, an air-stable, moisture-stable and highly efficient heterogenized palladium was synthesized by the coordination of palladium(II) acetate with poly(2-acrylamido-2-methyl-1-propanesulfonic acid)-grafted modified magnetic nanoparticles with a core-shell structure.The structure of the newly developed catalyst was characterized using various techniques. The catalytic activity of the resultant nano-organometallic catalyst was evaluated in Mizoroki-Heck and Suzuki-Miyaura reactions to afford the corresponding coupling products in good to excellent yields. High selectivity as well as outstanding turnover number (14 143, 4900) and turnover frequency (28 296, 7424) values were recorded for the catalyst in Suzuki-Miyaura and Mizoroki-Heck reactions, respectively. Magnetic separation and recycling of the catalyst for at least six runs became possible without any significant loss of efficiency or any detectable palladium leaching.

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Polymer grafted magnetic nanoparticles for delivery of anticancer drug at lower pH and elevated temperature

Cited by 56 publications

References 48 publications

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Environmental implications and applications of engineered nanoscale magnetite and its hybrid nanocomposites: A review of recent literature

Mizoroki–Heck and Suzuki–Miyaura reactions mediated by poly(2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid)‐stabilized magnetically separable palladium catalyst

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