Polymer mediated light responsive therapeutics delivery system to treat cancer

Kapoor, Devesh; Maheshwari, Neha; Bag, Anindita; Sharma, Mukesh C.; Prajapati, Bhupendra; Maheshwari, Rahul

doi:10.1016/j.eurpolymj.2024.112923

Cited by 4 publications

(1 citation statement)

References 185 publications

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“…This is due to its excellen characteristics, including low-cost production, non-toxic, mucoadhesive, biocompatibil ity, biodegradability, low immunogenicity, and antimicrobial and anticancer activitie Nanocomposites in drug delivery systems are used to avoid cancer cell treatment resistance. The literature documents the synthesis and manufacture of many conjugated materials, such as graphene-gold [61], chitosan-palladium [62], gold ferrite [63], and graphene oxide/bismuth selenide [64], among others, for drug delivery [65]. Furthermore, the presence of a magnetic field gradient facilitates the vectorization of nanocomposites within the tumor, enabling the administration of medication.…”

Section: Chitosan and Its Nanocomposites For Cancer Treatmentmentioning

confidence: 99%

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

El-Meligy,

Abd El-Monaem,

Eltaweil

et al. 2024

Molecules

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The rapid advancements in nanotechnology in the field of nanomedicine have the potential to significantly enhance therapeutic strategies for cancer treatment. There is considerable promise for enhancing the efficacy of cancer therapy through the manufacture of innovative nanocomposite materials. Metallic nanoparticles have been found to enhance the release of anticancer medications that are loaded onto them, resulting in a sustained release, hence reducing the dosage required for drug administration and preventing their buildup in healthy cells. The combination of nanotechnology with biocompatible materials offers new prospects for the development of advanced therapies that exhibit enhanced selectivity, reduced adverse effects, and improved patient outcomes. Chitosan (CS), a polysaccharide possessing distinct physicochemical properties, exhibits favorable attributes for controlled drug delivery due to its biocompatibility and biodegradability. Chitosan nanocomposites exhibit heightened stability, improved biocompatibility, and prolonged release characteristics for anticancer medicines. The incorporation of gold (Au) nanoparticles into the chitosan nanocomposite results in the manifestation of photothermal characteristics, whereas the inclusion of silver (Ag) nanoparticles boosts the antibacterial capabilities of the synthesized nanocomposite. The objective of this review is to investigate the recent progress in the utilization of Ag and Au nanoparticles, or a combination thereof, within a chitosan matrix or its modified derivatives for the purpose of anticancer drug delivery. The research findings for the potential of a chitosan nanocomposite to deliver various anticancer drugs, such as doxorubicin, 5-Fluroacil, curcumin, paclitaxel, and 6-mercaptopurine, were investigated. Moreover, various modifications carried out on the chitosan matrix phase and the nanocomposite surfaces to enhance targeting selectivity, loading efficiency, and pH sensitivity were highlighted. In addition, challenges and perspectives that could motivate further research related to the applications of chitosan nanocomposites in cancer therapy were summarized.

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Section: Chitosan and Its Nanocomposites For Cancer Treatmentmentioning

confidence: 99%

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

El-Meligy,

Abd El-Monaem,

Eltaweil

et al. 2024

Molecules

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Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications

Guo,

2024

WIREs Nanomed Nanobiotechnol

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Polymer–drug conjugates and polymer–protein conjugates have been pivotal in the realm of drug delivery systems for over half a century. These polymeric drugs are characterized by the conjugation of therapeutic molecules or functional moieties to polymers, enabling a range of benefits including extended circulation times, targeted delivery, controlled release, and decreased immunogenicity. This review delves into recent advancements and challenges in the clinical translations and preclinical studies of polymer–drug conjugates and polymer–protein conjugates. The design principles and functionalization strategies crucial for the development of these polymeric drugs were explored followed by the review of structural properties and characteristics of various polymer carriers. This review also identifies significant obstacles in the clinical translation of polymer–drug conjugates and provides insights into the directions for their future development.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Stimuli-responsive prodrugs with self-immolative linker for improved cancer therapy

Xu,

Jia,

Lei

et al. 2024

European Journal of Medicinal Chemistry

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Polymer mediated light responsive therapeutics delivery system to treat cancer

Cited by 4 publications

References 185 publications

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications

Stimuli-responsive prodrugs with self-immolative linker for improved cancer therapy

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