Polymer‐supported metal complexes as antibacterial agents: synthesis, characterization and thermal degradation kinetics

Abstract

Polymeric metal complexes were prepared using a synthesized novel terpolymer ligand involving anthranilic acid–o‐toluidine–formaldehyde by a polycondensation technique. The synthesized ligand and its metal complexes were characterized using elemental analysis and molar conductivity measurements, and FT‐IR, electronic, electron spin resonance and NMR (1H and 13C) spectral methods. The surface morphology and the nature of the synthesized compounds were examined using scanning electron microscopy and X‐ray diffraction. The thermal stabilities of the ligand and its metal complexes were determined using thermogravimetric analysis (TGA). From the TGA results, various kinetic parameters, i.e. activation energy and order of reaction, and thermodynamic parameters, i.e. entropy change, apparent entropy, frequency factor and free energy change, were determined using the Freeman–Carroll and Sharp–Wentworth methods. In addition, a thermal degradation model was also proposed using the Phadnis–Deshpande method. The thermal stability of the ligand and its metal complexes was found to be appreciably high; in particular, the ligand showed very high stability compared to its metal complexes due to intramolecular hydrogen bonding. Furthermore, the synthesized compounds were subjected to in vitro antibacterial studies with various microorganisms. The results of the studies confirmed that the compounds showed better antibacterial results than a standard antibacterial drug. Copyright © 2014 John Wiley & Sons, Ltd.

Unveiling a novel terpolymer-metal complex: A detailed exploration of synthesis, characterization, and its potential as an antimicrobial and antioxidant agent

“…The band appeared at 1439.65 cm −1 is due to aliphatic C–H stretching. Week band appeared in the region of 1273.98 cm −1 is assign to C–N stretching present in the terpolymer resin [ [17] , [18] , [19] , [20] , [28] , [29] , [30] ].

Figure-1 FTIR Spectrum of PAF terpolymer ligand.

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“…The signal appeared at 6.8–7.6 ( δ ) ppm is assigned to all the protons of aromatic protons. The signal observed at 2.5 ( δ ) ppm is assigned to methylene group [ [17] , [18] , [19] , [20] , 29 , 30 ].

Figure-5 1 H NMR spectrum of PAF Terpolymer.

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“…These activities are probably brought on by the presence of -N-H, –C S, groups [ [10] , [11] , [12] , [13] , [14] , [15] ]. Ahamad et al reported a new class of metal chelated polyurea for its excellent antimicrobial activity against S. aureus, E. coli, B. subtilis , and S. typhi [ [16] , [17] , [18] , [19] , [20] ]. Azo series based on transition metal complexes (Cu 2+ , Zn 2+ , Mn 2+ , Co 2+ and Ni 2+ ) were screened for their antibacterial and antifungal activities against S. aureus, E. coli and A. niger and C. albicans [ 21 ].…”