Polymeric and lipid-based drug delivery systems for treatment of glioblastoma multiforme

Duwa, Ramesh; Emami, Fakhrossadat; Lee, Sooyeun; Jeong, Jee‐Heon; Yook, Simmyung

doi:10.1016/j.jiec.2019.06.050

Cited by 36 publications

(22 citation statements)

References 166 publications

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“…The most common and aggressive malignancy in brain tumors is Glioblastoma Multiforme (GBM)( Duwa et al, 2019 ; Gong et al, 2019 ; Le Reste et al, 2020 ; Rahn et al, 2020 ). Currently, surgical resection, chemotherapy, and radiation therapy are mainly used for treatment, but the tumor often regrowth and the survival rate of GBM patients is low (Jeong et al, 2008 ; Floyd et al, 2015 ; Hotchkiss & Sampson, 2021 ).…”

Section: Applicationmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

310

106

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Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

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Section: Applicationmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

310

106

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“…The conventional chemotherapy causes a lack of tumor selective drug release, causing dose-limiting adverse effects and low bioavailability at the cancer site. To overcome these problems, drugs encapsulated in biocompatible lipids through I.V administration should be established to enhance bioavailability and promote selective targeting of tumor cells [107]. Stimuli-responsive lipids represent a unique class of lipids or amphiphiles used to induce transitions between a dissolution of the assembly or supramolecular states by the application of internal or external stimulus, e.g., temperature-responsive lipids, lightresponsive lipids, pH-responsive lipids, sound-responsive lipids, electric field-responsive lipids and magnetic field-responsive lipids as illustrated in Figures 3 and 4 [108,109].…”

Section: Stimuli-responsive Lipidsmentioning

confidence: 99%

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim

Jan

Khan

et al. 2021

Cancers

137

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The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been carried out to investigate chemotherapy-based targeted drug delivery, the identification of the most promising strategy capable of bypassing non-specific cytotoxicity is still a major concern. Recent advancements in the arena of onco-targeted therapies have enabled safe and effective tumor-specific localization through stimuli-responsive drug delivery systems. Owing to their promising characteristic features, stimuli-responsive drug delivery platforms have revolutionized the chemotherapy-based treatments with added benefits of enhanced bioavailability and selective cytotoxicity of cancer cells compared to the conventional modalities. The insensitivity of stimuli-responsive drug delivery platforms when exposed to normal cells prevents the release of cytotoxic drugs into the normal cells and therefore alleviates the off-target events associated with chemotherapy. Contrastingly, they showed amplified sensitivity and triggered release of chemotherapeutic payload when internalized into the tumor microenvironment causing maximum cytotoxic responses and the induction of cancer cell necrosis. This review focuses on the physical stimuli-responsive drug delivery systems and chemical stimuli-responsive drug delivery systems for triggered cancer chemotherapy through active and/or passive targeting. Moreover, the review also provided a brief insight into the molecular dynamic simulations associated with stimuli-based tumor targeting.

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“…Methyldiazonium, an active cation, then methylates the nucleobases, preferentially N 7 position of guanine (N 7 -MeG; 70%), guanine rich site and to a certain extend at N 3 adenine (N 3 -MeA; 9%) and O 6 guanine residues (O 6 -MeG; 6%) [ 59 , 60 ]. This results in the formation of nicks in the DNA resulting in apoptosis and cell cycle arrest at the G 2 /M phase [ 60 , 61 ].…”

Section: Overview Of Standard Therapy In Hggmentioning

confidence: 99%

Challenges and Perspectives of Standard Therapy and Drug Development in High-Grade Gliomas

et al. 2021

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Despite their low incidence rate globally, high-grade gliomas (HGG) remain a fatal primary brain tumor. The recommended therapy often is incapable of resecting the tumor entirely and exclusively targeting the tumor leads to tumor recurrence and dismal prognosis. Additionally, many HGG patients are not well suited for standard therapy and instead, subjected to a palliative approach. HGG tumors are highly infiltrative and the complex tumor microenvironment as well as high tumor heterogeneity often poses the main challenges towards the standard treatment. Therefore, a one-fit-approach may not be suitable for HGG management. Thus, a multimodal approach of standard therapy with immunotherapy, nanomedicine, repurposing of older drugs, use of phytochemicals, and precision medicine may be more advantageous than a single treatment model. This multimodal approach considers the environmental and genetic factors which could affect the patient’s response to therapy, thus improving their outcome. This review discusses the current views and advances in potential HGG therapeutic approaches and, aims to bridge the existing knowledge gap that will assist in overcoming challenges in HGG.

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Polymeric and lipid-based drug delivery systems for treatment of glioblastoma multiforme

Cited by 36 publications

References 166 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Challenges and Perspectives of Standard Therapy and Drug Development in High-Grade Gliomas

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