Polymeric devices containing imprinted nanospheres: a novel approach to improve recognition in water for clinical uses

Silvestri, Davide; Borrelli, Cristiana; Giusti, P.; Cristallini, Caterina; Ciardelli, Gianluca

doi:10.1016/j.aca.2004.12.005

Cited by 58 publications

(43 citation statements)

References 19 publications

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“…OCBZ has a structure similar to that of CBZ. The selectivity factor a as a ratio between template and template analogue binding calculated as indicated in the following equation [34]:…”

Section: Selectivity Factormentioning

confidence: 99%

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Esfandyari-Manesh

Javanbakht

Dinarvand

et al. 2012

J Mater Sci: Mater Med

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Water-compatible imprinted nanoparticles were prepared for carbamazepine as a template and used for the selective extraction and controlled release of carbamazepine. Assay materials and drug delivery carriers were typically used in aqueous environments, so it is generally preferable to prepare solvent-free molecularly imprinted nanoparticles in water using the miniemulsion polymerization method. The present work investigates a bio-analytical strategy generically applicable to imprinted materials for molecular recognition studies, including equilibrium and non-equilibrium binding, and release experiments, increasing the knowledge of the molecular interactions between the template molecules and imprinted nanoparticles. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles. The selectivity of imprinted nanoparticles for carbamazepine studied in comparison with an analogue compound, oxcarbazepine, the main metabolite of carbamazepine. The recovery and selectivity of carbamazepine in human serum was determined to be 100%, 1.7 times that of oxcarbazepine. The results indicated that carbamazepine-imprinted nanoparticles are appropriate for serum level determination of the drug in therapeutic range. The template to functional monomer ratio as a key factor controlling the recognition and release kinetic mechanism of imprinted nanoparticles is discussed. The imprinted nanoparticles prepared at the appropriate template to functional monomer mole ratio (2:8) exhibited the best drug affinity (5.1 times higher) and a slower drug release rate due to the interaction of carbamazepine with the imprinted cavities within the nanoparticles. Loaded imprinted nanoparticles as drug reservoirs were able to prolong carbamazepine release, in 1% wt sodium dodecyl sulfate aqueous solution, for more than 8 days.

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“…OCBZ has a structure similar to that of CBZ. The selectivity factor a as a ratio between template and template analogue binding calculated as indicated in the following equation [34]:…”

Section: Selectivity Factormentioning

confidence: 99%

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Esfandyari-Manesh

Javanbakht

Dinarvand

et al. 2012

J Mater Sci: Mater Med

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“…The conventional method for preparing MIP is via solution polymerization followed by mechanical grinding of the resulting bulk polymer generated to give small particles and sieve the particles into the desired size ranges, which diameters usually in the micrometer range [52][53]. This method, by far the most popular, presents many attractive properties, especially to newcomers.…”

Section: Bulk Polymerizationmentioning

confidence: 99%

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Yan

Row

2006

IJMS

460

231

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Abstract:Molecularly imprinted polymers (MIP) exhibiting high selectivity and affinity to the predetermined molecule (template) are now seeing a fast growing research. However, optimization of the imprinted products is difficult due to the fact that there are many variables to consider, some or all of which can potentially impact upon the chemical, morphological and molecular recognition properties of the imprinted materials. This review present a summary of the principal synthetic considerations pertaining to good practice in the polymerization aspects of molecular imprinting, and is primarily aimed at researcher familiar with molecular imprinting methods but with little or no prior experience in polymer synthesis. The synthesis, characteristic, effect of molecular recognition and different preparation methods of MIP in recent few years are discussed in this review, unsolved problems and possible developments of MIP were also been briefly discussed.

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“…Second method is to mix the nano imprinted sphere into the polymer solution and entrapped inside the matrix during coagulation. [128][129] A cryogel molecular imprinted composite membrane was synthesized by Asliyuce, anti-hepatitis B imprinted particle was first prepared, then introduced to a poly HEMA based polymer matrix by mixture and subsequent radical polymerization.…”

Section: Molecular Imprinted Composite Membrane Adsorbersmentioning

confidence: 99%

Protein-selective adsorbers by molecular imprinting via a novel two-step surface grafting method

Yin

Ulbricht

2013

J. Mater. Chem. B

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Molecularly imprinted polymers (MIP) offer in principle a robust, cost-efficient alternative to antibodies, but it is still a challenge to develop such materials for protein recognition. Here we report the molecular imprinting of a functional polymeric hydrogel layer with whole protein lysozyme as template in two-step grafting procedure by a novel initiation approach on track-etched (TE) polyethylene terephthalate (PET) and cellulose membrane surfaces.This two-step grafting strategy is based on surface functionalization with aliphatic C-Br groups which can be used as initiator for surface-initiated atom transfer radical polymerization (SI-ATRP) and photo-initiated copolymerization. At first, the scaffold poly(methacrylic acid) (PMAA) was obtained through SI-ATRP of poly(tert.-butyl methacrylate) (PtBMA) and subsequent hydrolysis. Thereafter, it was assembled with the template to form a stable PMAA/protein complex. In the second step, a polyacrylamide I declare that this dissertation represents my own work, except where due acknowledgement is made.

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Polymeric devices containing imprinted nanospheres: a novel approach to improve recognition in water for clinical uses

Cited by 58 publications

References 19 publications

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Protein-selective adsorbers by molecular imprinting via a novel two-step surface grafting method

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