Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease.

“…emulsification of organic phase into the non-solvent phase (aqueous phase) [189]. The rapid diffusion of solvent phase into the aqueous phase leads to precipitation and formation of nanoparticles [190].…”

“…The rapid diffusion of solvent phase into the aqueous phase leads to precipitation and formation of nanoparticles [190]. The emulsification techniques are widely applicable methods for the preparation of nanoparticles that mainly depends upon the formation of a nanoemulsion firstly before the nanoparticle formation [189]. The techniques include emulsificationdiffusion, emulsification-coacervation, emulsificationevaporation, and double or multiple emulsification methods.…”

“…The method is usually depending on the preparation of nanoemulsion and followed by solvent evaporation leading to polymer precipitation as nanoparticles [198]. The main drawback of this method is the formation of multiple interfaces in organic and aqueous phases leading to the restriction of solvent diffusion [189]. Furthermore, the multipleemulsification technique and the most common form, the double-emulsification method is a modified form of the emulsion-evaporation technique [199,200], in which multiple emulsions to be formed before solvent evaporation.…”

“…The method is used for encapsulation of both hydrophilic and lipophilic drug molecules by the formation of W/O/W [201,202] and O/W/O emulsions, respectively [203,204]. Finally, the emulsioncoacervation method is mainly used for the manufacturing of nanoparticles from natural polymers like gelatin and sodium alginate [189]. The method depends mainly on the formation of nanoemulsion then coacervation which results in polymer precipitation.…”

“…Nanoparticles properties and characterization are based upon some physicochemical properties like particle size, surface charge and the particle morphology [189]. It is very important properties for the interactions between the nanoparticles and biological systems and control nanoparticles therapeutic activity and its toxicity.…”