Polymeric gels for the controlled drug delivery applications

Balavigneswaran, Chelladurai Karthikeyan; Misra, Nira

doi:10.1016/b978-0-08-102179-8.00013-2

Cited by 5 publications

(2 citation statements)

References 70 publications

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“…PHEMA is a hydrophilic, biocompatible, and non-toxic polymer [ 7 , 8 ] that was developed and studied as a material for soft contact lenses [ 9 ] as well as for ophthalmic drug delivery [ 10 ]. So far, only a few studies have explored the potential of PHEMA as drug delivery systems for DXP, all of them being focused on DXP ocular delivery [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Interpenetrating Polymer Networks of Poly(2-hydroxyethyl methacrylate) and Poly(N, N-dimethylacrylamide) as Potential Systems for Dermal Delivery of Dexamethasone Phosphate

Simeonov,

Kostova,

Vassileva

2023

Pharmaceutics

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In this study, a series of novel poly(2-hydroxyethyl methacrylate) (PHEMA)/poly(N,N′-dimethylacrylamide) (PDMAM) interpenetrating polymer networks (IPNs) were synthesized and studied as potential drug delivery systems of dexamethasone sodium phosphate (DXP) for dermal application. The IPN composition allows for control over its swelling ability as the incorporation of the highly hydrophilic PDMAM increases more than twice the IPN swelling ratio as compared to the PHEMA single networks, namely from ~0.5 to ~1.1. The increased swelling ratio of the IPNs results in an increased entrapment efficiency up to ~30% as well as an increased drug loading capacity of DXP up to 4.5%. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show the formation of a solid dispersion between the drug DXP and the polymer (IPNs) matrix. Energy-dispersive X-ray (EDX) spectroscopy shows an even distribution of DXP within the IPN structure. The DXP release follows Fickian diffusion with ~70% of DXP released in 24 h. This study demonstrates the potential of the newly developed IPNs for the dermal delivery of DXP.

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Section: Introductionmentioning

confidence: 99%

Interpenetrating Polymer Networks of Poly(2-hydroxyethyl methacrylate) and Poly(N, N-dimethylacrylamide) as Potential Systems for Dermal Delivery of Dexamethasone Phosphate

Simeonov,

Kostova,

Vassileva

2023

Pharmaceutics

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“…The potential of dependal-M loaded hydrogel matrix has been used in the rehydration therapy and the hydrogel with lesser cross linker amount has a higher drug loading capacity [3]. It has been reported that polymer nanoparticles are the responsive materials for drug delivery applications [4,5].…”

Section: Introductionmentioning

confidence: 99%

Simulation Study of Structural and Dynamic Properties of Bi-Disperse Colloidal Suspensions

Irfachsyad

Meidia

2020

MSF

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We used Brownian Dynamic simulation to study structural and dynamic properties of bi-disperse colloidal suspensions. The size ratio of large to small particles in the bi-disperse colloidal suspension is set at 5:1 and 10:1. We studied the interaction of aggregates (clusters) formed through DLVO (Derjaguin, Landau, Verwey and Overbeek) and soft sphere interactions in a bi-disperse suspension. The dynamic properties of bi-disperse is correlated by varying the size ratio of bi-disperse particles, it is found that the mobility is decreased at size ratio of large to small particles is 5:1. This is despite the percolating particle gels formation was disrupted by larger particles at higher size ratio.

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Polymeric Gels

Triboni¹,

Moraes²

2019

Nano Design for Smart Gels

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Polymeric gels for the controlled drug delivery applications

Cited by 5 publications

References 70 publications

Interpenetrating Polymer Networks of Poly(2-hydroxyethyl methacrylate) and Poly(N, N-dimethylacrylamide) as Potential Systems for Dermal Delivery of Dexamethasone Phosphate

Interpenetrating Polymer Networks of Poly(2-hydroxyethyl methacrylate) and Poly(N, N-dimethylacrylamide) as Potential Systems for Dermal Delivery of Dexamethasone Phosphate

Simulation Study of Structural and Dynamic Properties of Bi-Disperse Colloidal Suspensions

Polymeric Gels

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