2014
DOI: 10.1016/j.biomaterials.2014.04.072
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Polymeric micelles for GSH-triggered delivery of arsenic species to cancer cells

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Cited by 49 publications
(49 citation statements)
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“…Amphiphilic block copolymer with its aqueous and organic moieties can form nanoemulsions in aqueous medium through the self-molecular interactions to entrap the hydrophobic medications in the central portion of micelles. 13 These novel delivery systems have been successfully employed with various medications such as anticancer drugs, 14 immunosuppressants, 11 vitamins, 15 and others to improve their therapeutic efficacy. Eudragit ® S100 is an anionic copolymerization product of methacrylic acid to methyl methacrylate in the ratio of 1:2.…”
Section: Introductionmentioning
confidence: 99%
“…Amphiphilic block copolymer with its aqueous and organic moieties can form nanoemulsions in aqueous medium through the self-molecular interactions to entrap the hydrophobic medications in the central portion of micelles. 13 These novel delivery systems have been successfully employed with various medications such as anticancer drugs, 14 immunosuppressants, 11 vitamins, 15 and others to improve their therapeutic efficacy. Eudragit ® S100 is an anionic copolymerization product of methacrylic acid to methyl methacrylate in the ratio of 1:2.…”
Section: Introductionmentioning
confidence: 99%
“…In 2014, the Le group reported the utilization of side-chain arsenic-containing polymers as new anticancer drugs. 169 They first synthesized prodrugs of poly(ethylene oxide)- b -poly[ a -(6-mecaptohexyl amino)carboxylate- e -caprolactone] (PEO- b -PCCL). The PEO- b -PCCL was then functionalized with thiol groups, which could bind with phenylasenic oxide via As-S bonds (Fig.…”
Section: Metal-containing Polymeric Drugs and Biocidesmentioning
confidence: 99%
“…An amphiphilic, biodegradable diblock copolymer PEG‐ b ‐(α‐carboxylate‐ε‐caprolactone) (PEG‐ b ‐PCCL) was synthesized by ring‐opening polymerization (ROP). Thiol groups, for arsenical conjugation, were introduced into the hydrophobic caprolactone block via amidation of the pendant carboxylate group using mercaptohexylamine (PEG‐ b ‐PCCLSH) . The resulting thiol functional block polymers could be assembled in water, toluene, and DMAc forming particles with D h = 136, 35, and 54 nm, respectively.…”
Section: Combining Nanoparticles and Organic Arsenicalsmentioning
confidence: 99%