Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

Hwang, Duhyeong; Ramsey, Jacob D.; Kabanov, Alexander V.

doi:10.1016/j.addr.2020.09.009

Cited by 412 publications

(267 citation statements)

References 341 publications

(532 reference statements)

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“… 86 Polymeric micelles consist of amphiphilic block copolymers, having a hydrophilic shell and a hydrophobic core, which can be used as a promising drug delivery system for the hydrophobic drugs. 87 Table 1 has listed the micelles encapsulated with GA.…”

Section: Nano-scale Drug Delivery Systemsmentioning

confidence: 99%

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Liu

Chen

Lin

et al. 2020

IJN

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Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.

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Section: Nano-scale Drug Delivery Systemsmentioning

confidence: 99%

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Liu

Chen

Lin

et al. 2020

IJN

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“…Due to their special sizes, polymer micelles could realize the advantages of passive targeting tumor through enhanced permeability and retention (EPR) effect [ 14 ]. Moreover, the micelles could avoid the traditional adverse side effects of chemotherapy, avoid fast kidney removal and extend the time of drug circulation, which could achieve sustained drug release behavior and improve the bioavailability and stability [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Eﬃcient drug delivery and anticancer eﬀect of micelles based on vitamin E succinate and chitosan derivatives

Chen

Sun

et al. 2021

Bioactive Materials

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Nanocarriers have emerged as a promising cancer drug delivery strategy. Multi-drug resistance caused by overexpression of multiple-drug excretion transporters in tumor cells is the major obstacle to successful chemotherapy. Vitamin E derivatives have many essential functions for drug delivery applications, such as biological components that are hydrophobic, stable, water-soluble enhancing compounds, and anticancer activity. In addition, vitamin E derivatives are also effective mitocan which can overcome multi-drug resistance by binding to P glycoproteins. Here, we developed a carboxymethyl chitosan/vitamin E succinate nano-micellar system ( O -CMCTS-VES). The synthesized polymers were characterized by Fourier Transform IR, and 1 H NMR spectra. The mean sizes of O -CMCTS-VES and DOX-loaded nanoparticles were around 177 nm and 208 nm. The drug loading contents were 6.1%, 13.0% and 10.6% with the weight ratio of DOX to O -CMCTS-VES corresponding 1:10, 2:10 and 3:10, and the corresponding EEs were 64.3%, 74.5% and 39.7%. Cytotoxicity test, hemolysis test and histocompatibility test showed that it had good biocompatibility in vitro and in vivo . Drug release experiments implied good pH sensitivity and sustained-release effect. The DOX/ O -CMCTS-VES nanoparticles can be efficiently taken up by HepG2 cancer cells and the tumor inhibition rate is up to 62.57%. In the in vivo study by using H22 cells implanted Balb/C mice, DOX/ O -CMCTS-VES reduced the tumor volume and weight efficiently with a TIR of 35.58%. The newly developed polymeric micelles could successfully be utilized as a nanocarrier system for hydrophobic chemotherapeutic agents for the treatment of solid tumors.

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“…Biocompatible and biodegradable polymers are widely used in pharmaceutical processes as useful components for pharmaceutical formulations and also utilized as nanocarriers in drug delivery systems [157]. Currently, micelles are based on the use of amphiphilic block copolymers in aqueous solution.…”

Section: Polymeric Micellesmentioning

confidence: 99%

“…Currently, micelles are based on the use of amphiphilic block copolymers in aqueous solution. They can be employed as nanocarriers for less soluble drugs that may be covalently attached to polymer chains or non-covalently placed in micelles [157]. Generally, they are suitable nanovehicles to improve several biochemical and biopharmaceutical properties such as solubility, bioavailability, and targeting of these hydrophobic drugs.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.

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Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

Cited by 412 publications

References 341 publications

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Eﬃcient drug delivery and anticancer eﬀect of micelles based on vitamin E succinate and chitosan derivatives

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

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