Polymeric microdevices for transdermal and subcutaneous drug delivery

Ochoa, Manuel; Mousoulis, Charilaos; Ziaie, Babak

doi:10.1016/j.addr.2012.09.035

Cited by 55 publications

(24 citation statements)

References 49 publications

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“…Drug delivery across skin has a variety of advantages including avoidance of firstpass metabolism and drug degradation of the GI tract compared with the oral route, as well as less pain and reduced side effects due to transiently high plasma drug concentration compared with hypodermic injections. [217][218][219] The greatest challenge for transdermal delivery might be that only small hydrophobic drugs (molecular weight <500 Da) can effectively be delivered by this route because the resistance to drug transport resulted from the outermost layer of skin, known as the stratum corneum lipid bilayers.…”

Section: Transdermal Deliverymentioning

confidence: 99%

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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Microfabrication technology has enabled the development of novel controlled-release devices that possess an integration of structural, mechanical, and perhaps electronic features, which may address challenges associated with conventional delivery systems. In this feature article, microfabricated devices are described in terms of materials, mechanical design, working principles, and fabrication methods, all of which are key features for production of multifunctional, highly effective drug delivery systems. In addition, the current status and future prospects of different types of microfabricated devices for controlled drug delivery are summarized and analyzed with an emphasis on various routes of administration including ocular, oral, transdermal, and implantable systems. It is likely that microfabrication technology will continue to offer new, alternative solutions to design advanced and sophisticated drug delivery devices that promise to significantly improve medical care.

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Section: Transdermal Deliverymentioning

confidence: 99%

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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“…Compared to other routes, transdermal route is proved to be advantageous due to the following reasons: (i) better patient compliance as the administration is convenient and noninvasive in nature, (ii) reduction in dosing, (iii) avoidance of first pass metabolism and (iv) prevention of gastrointestinal irritation due to the contact of certain active ingredients to gastric mucosa [6]. Among transdermal systems, self-adhesive films are considered as an innovative drug delivery system to achieve systemic effect through skin application [7].…”

Section: Introductionmentioning

confidence: 98%

Transdermal delivery of Diltiazem HCl from matrix film: Effect of penetration enhancers and study of antihypertensive activity in rabbit model

Parhi

Suresh²

2016

Journal of Advanced Research

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The present investigation focused on the development of Diltiazem HCl (DTH) matrix film and its characterization by in-vitro, ex-vivo and in-vivo methods. Films were prepared by solvent casting method by taking different ratios of hydroxypropyl methylcellulose K4M (HPMC K4M) and Eudragit RS100. Various parameters of the films were analyzed such as mechanical property using tensile tester, interaction study by Fourier transform infrared spectroscopy (FTIR) and Thermogravimetric analysis (TGA), in-vitro drug release through cellulose acetate membrane, ex-vivo permeation study using abdominal skin of rat employing Franz diffusion cell, and in-vivo antihypertensive activity using rabbit model. The FTIR studies confirmed the absence of interaction between DTH and selected polymers. Thermal analysis showed the shifting of endothermic peak of DTH in film, indicating the dispersion of DTH in molecular form throughout the film. Incorporation of 1,8-cineole showed highest flux (89.7 μg/cm(2)/h) of DTH compared to other penetration enhancers such as capsaicin, dimethyl sulfoxide (DMSO), and N-methyl pyrrolidone (NMP). Photomicrographs of histology study on optimized formulation (DF9) illustrated disruption of stratum corneum (SC) supporting the ex-vivo results. The in-vivo antihypertensive activity results demonstrated that formulation DF9 was effective in reducing arterial blood pressure in normotensive rabbits. SEM analysis of films kept for stability study (40 ± 2 °C/75% ± 5%RH for 3 months) revealed the formation of drug crystals which may be due to higher temperature. The findings of the study provide a better alternative dosage form of DTH for the effective treatment of hypertension with enhanced patient compliance.

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“…The ability to enable release of drugs to the targeted area in a controlled manner reduces the side effects to the patient while enhancing therapeutic effectiveness [5]. Transdermal and subcutaneous drug delivery systems using micro needle [6][7][8], for instance, have been proven as a viable method in delivering adequate dosage administration across the skin. Nonetheless, most of the micropumps proposed [9][10][11] for drug delivery application involve utilizing active power circuitry, making the system tend to have relatively large dimensions with limited space and constricted the system's mobility.…”

Section: Introductionmentioning

confidence: 99%

Thermal analysis of wirelessly powered thermo-pneumatic micropump based on planar LC circuit

et al. 2016

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This paper studies the thermal behavior of a wireless powered micropump operated using thermo-pneumatic actuation. Numerical analysis was performed to investigate the temporal conduction of the planar inductor-capacitor (LC) wireless heater and the heating chamber. The result shows that the temperature at the heating chamber reaches steady state temperature of 46.7°C within 40 seconds. The finding was further verified with experimental works through the fabrication of the planar LC heater (RF sensitive actuator) and micropump device using MEMS fabrication technique. The fabricated device delivers a minimum volume of 0.096 µL at the temperature of 29°C after being thermally activated for 10 s. The volume dispensed from the micropump device can precisely controlled by an increase of the electrical heating power within the cut-off input power of 0.22 W. Beyond the power, the heat transfer to the heating chamber exhibits non-linear behavior. In addition, wireless operation of the fabricated device shows successful release of color dye when the micropump is immersed in DI-water containing dish and excited by tuning the RF power.

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Polymeric microdevices for transdermal and subcutaneous drug delivery

Cited by 55 publications

References 49 publications

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Transdermal delivery of Diltiazem HCl from matrix film: Effect of penetration enhancers and study of antihypertensive activity in rabbit model

Thermal analysis of wirelessly powered thermo-pneumatic micropump based on planar LC circuit

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