Polymeric microneedle‐mediated sustained release systems: Design strategies and promising applications for drug delivery

Yang, Li; Yang, Yao; Chen, Hongzhong; Mei, Lin; Zeng, Xiaowei

doi:10.1016/j.ajps.2021.07.002

Cited by 52 publications

(44 citation statements)

References 188 publications

(207 reference statements)

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“…Once the needle reaches a moist environment, they start to dissolve into liquid. The drug that was mixed within the needle is released simultaneously, and the speed at which the needles dissolve can be designed by altering the reagent content (Bariya et al, 2011 ; Avcil & Çelik, 2021 ; Yang et al, 2022 ). The prolonged drug releasing effect can also be extended to days instead of just hours via the SC method (Tran et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model

Nguyen

Yoo

An³

et al. 2022

Drug Delivery

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Much research has shown Bee venom to be an effective neuroprotective agent. However, the usual transdermal injection of bee venom poses many pharmacokinetic disadvantages. Here, we compared the administration of bee venom via subcutaneous injection (SC) and via Microneedle patch (MN). Both administrated routes produce significant recovery effects, however: the MN significantly prolongs the bio-significant-and-yet-lower concentration of bee venom in mice bodies. In contrast, SC could produce only a short period of much higher bee venom levels in the blood and brain. We also see that due to the concentration-response-curve of bee venom (represented by melittin): mice bodies do not require much higher bee venom concentration (seen in the SC group) to produce a much more significant neuroprotective effect (than seen in those treated with the MN method). Therefore, a MN could maintain bee venom levels in mice bodies at lower-yet-more-efficient concentrations. This is important, as bee venom can cause more adverse effects and pain sensations, at higher concentrations. For the first time, we confirmed that the pharmacokinetic advantages of MN delivered bee venom also guarantee a holistic neuroprotection effect (which was shown by SC delivered bee venom in previous research). This was proven via the results of the water maze experiments for long-term learning memory assessment and protein analysis of key neuronal regulatory proteins: BDNF, p-CREB, iNOS, and mArhR 1. In conclusion, for situations where we ought to administrate drugs at a more downward amount, such as bee venom, MN can keep the therapeutic concentrations at a lower, yet interestingly, more-efficient level.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model

Nguyen

Yoo

An³

et al. 2022

Drug Delivery

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“…Furthermore, fast detachable long-acting MNPs may decrease dosage frequencies while keeping a constant pharmacokinetic profile, improving patient compliance and therapeutic efficiency. Various studies have been reported to use these implantable MNPs to provide a long-term profile release for different contraceptives, antimicrobials, antidiabetics, and vaccines as great therapy agents. ,− …”

Section: Biodegradable Platforms In Vaccine Deliverymentioning

confidence: 99%

Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

Malek-Khatabi

Tabandeh

Nouri

et al. 2022

ACS Appl. Bio Mater.

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Biodegradable polymers are largely employed in the biomedical field, ranging from tissue regeneration to drug/vaccine delivery. The biodegradable polymers are highly biocompatible and possess negligible toxicity. In addition, biomaterial-based vaccines possess adjuvant properties, thereby enhancing immune responses. This Review introduces the use of different biodegradable polymers and their degradation mechanism. Different kinds of vaccines, as well as the interaction between the carriers with the immune system, then are highlighted. Natural and synthetic biodegradable micro-/nanoplatforms, hydrogels, and scaffolds for local or targeted and controlled vaccine release are subsequently discussed.

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“…Dual continuous release MNs is the third strategy of MN@SRS. These MNs load long-acting packaged drugs into sustained release MNs to achieve a longer sustained release period 59 . Nanogel Nanogel is defined as nanoparticles composed of crosslinked hydrophilic structures.…”

Section: Polymeric Microneedle Systemsmentioning

confidence: 99%

Innovative Drug Delivery Systems for Infectious Diseases of the Skin

Esentürk-Güzel

Kara²

2022

Univ J Pharm Res

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Introduction: Skin is the organ of the body that is exposed mostly to the microorganisms. Bacteria, fungi, and viruses are usually responsible for the infection of the skin. Due to lack of penetration through the stratum corneum of conventional systems used in infectious diseases of the skin leads to a decrease in bioavailability. For this reason, nanoscale drug delivery systems that could be used in infectious diseases of the skin are currently being investigated. Areas covered: In this review, innovative studies conducted over the years are presented. New topical formulations such as nanoparticles, microemulsions, liposomes, nanofibers and micelles etc are widely used and topic of research for many researchers. Conclusion:Studies have shown that the smaller size and control of these delivery systems provide more effective treatment by increasing drug penetration into the skin. It has been found that drug delivery systems provide a better antimicrobial effect, especially in resistant infections caused by MRSA.

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Polymeric microneedle‐mediated sustained release systems: Design strategies and promising applications for drug delivery

Cited by 52 publications

References 188 publications

Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model

Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model

Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

Innovative Drug Delivery Systems for Infectious Diseases of the Skin

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