Polymeric microsponges: an emerging prospect in topical delivery of therapeutic agents

Kumar, Lalit; Chadha, Mandeep S.; Rana, Ritesh; Kukreti, Gauree; Kaundal, Amit Kumar; Aggarwal, Vikas; Vij, Mohit

doi:10.1080/00914037.2023.2235872

Cited by 3 publications

(3 citation statements)

References 102 publications

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“…These qualities work together to improve the efficacy and safety of microsponge-based drug delivery systems. Polymers such as ethyl cellulose, polystyrene, Eudragit RS 100, polylactide-co-glycolic acid, Eudragit RS PO, polylactic acid, Eudragit S-100, and polyvinyl benzene are used to manufacture microsponge [28] . These polymers can form a porous structure for drug encapsulation, are biodegradable, have low toxicity, are pH-responsive, have mucoadhesive qualities, and are compatible with a wide range of drugs [29] .…”

Section: Preparation Of Microspongesmentioning

confidence: 99%

“…A microsponge of approximately 25 µm can have about 25,000 pores over its surface and an internal pore structure of approximately 10 feet in length. Hence, is capable of offering a volume of about 1 mL/g which is a large reservoir with each microsponge for drug entrapment (up to 3 times its own body weight) [3] .…”

Section: Introductionmentioning

confidence: 99%

“…Sustain drug release of microsponges is associated with the increased bioavailability of drugs [9] . Microsponges can be employed to incorporate solids and liquids/ oils, which are thermally (up to 130 °C ), physically and chemically stable (pH range of [1][2][3][4][5][6][7][8][9][10][11] without the use of preservatives [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Advancements in microsponges for the management of vaginal and colorectal diseases: A comprehensive review

Rathi,

Kaur,

Chopra

et al. 2024

Appl. Chem. Eng.

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The controlled-release drug delivery systems have risen dramatically allowing various factors such as the prohibitive cost of developing new entities, the expiration of existing international patents, and the discovery of new polymeric materials suitable for prolonged drug release and improvement in therapeutic efficacy. Microsponges are the porous microspheres-based polymeric delivery system that allows controlled drug release at a specific site. Microsponges are developed for the efficient delivery of active ingredients at a low dose. They help in improving stability by modifying drug release kinetics, reducing side effects, and enhancing the retention of drug entities. Microsponge compositions are stable throughout a wide pH and temperature range, making them more compatible with numerous vehicles, and ingredients. Several studies have shown that microsponges are non-irritant, non-toxic, non-mutagenic, and non-allergic with self-sterilizing properties. They are typically used for topical administration but have lately been used for oral, vaginal, and colorectal administration as well. The current review contains basic information about microsponges, their method of preparation, and various characterization parameters. The review also discusses the application of microsponges in vaginal and colorectal diseases. The latter portion of the script includes various patents and preclinical trials.

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Section: Preparation Of Microspongesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Advancements in microsponges for the management of vaginal and colorectal diseases: A comprehensive review

Rathi,

Kaur,

Chopra

et al. 2024

Appl. Chem. Eng.

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Preparation of Microsponge Drug Delivery System (MSDDS) Followed by a Scale-Up Approach

Halder,

Behera,

Poddar

et al. 2024

AAPS PharmSciTech

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A Comprehensive Review on Microsponges Drug Delivery Systems

Sah,

Kohri,

Patil

2024

J. Res. Appl. Sci. Biotechnol.

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The special qualities of microsponges are making them a promising drug delivery system. These cross-linked, highly porous polymer particles have the capacity to encapsulate and release medications in a regulated fashion. Microsponges can effectively entrap both hydrophilic and hydrophobic drugs, improving their stability and preventing drug degradation, thanks to their large internal surface area and adjustable pore sizes. Innovative drug delivery devices known as microsponges have drawn a lot of interest from the pharmaceutical industry. The controlled and sustained release of medications is made possible by these porous, polymeric structures, which also minimise side effects and increase patient compliance. These systems also provide regulated release kinetics, which enhance bioavailability and minimise adverse effects. Because microsponges can be used topically or orally, they can be used for a wide range of therapeutic purposes. The potential of microsponges as adaptable drug delivery devices that could completely change the pharmaceutical formulation industry.

show abstract

Polymeric microsponges: an emerging prospect in topical delivery of therapeutic agents

Cited by 3 publications

References 102 publications

Advancements in microsponges for the management of vaginal and colorectal diseases: A comprehensive review

Advancements in microsponges for the management of vaginal and colorectal diseases: A comprehensive review

Preparation of Microsponge Drug Delivery System (MSDDS) Followed by a Scale-Up Approach

A Comprehensive Review on Microsponges Drug Delivery Systems

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