Polymeric Nanoparticle Associated with Ceftriaxone and Extract of Schinopsis Brasiliensis Engler against Multiresistant Enterobacteria

Oliveira, Maísa Soares de; Oshiro, João Augusto; Sato, Mariana Rillo; Conceição, Marta Maria da; Medeiros, Ana Cláudia Dantas de

doi:10.3390/pharmaceutics12080695

Cited by 18 publications

(8 citation statements)

References 63 publications

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“…The antibacterial activity of these polymeric systems was evaluated against multi-drug-resistant Enterobacteriaceae , namely ESBL-producing (extended-spectrum beta-lactamases) E. coli clinical isolates and carbapenemase-producing K. pneumoniae clinical isolates. The results revealed a considerable improvement in the antibacterial activity, the polymeric systems reaching an improvement of 133 times in the minimum inhibitory activity of ceftriaxone [ 73 ].…”

Section: Pharmacological Potential Of Chitosan and Its Derivatives Applications In Current Pharmacotherapymentioning

confidence: 99%

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

et al. 2021

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Despite the advantages presented by synthetic polymers such as strength and durability, the lack of biodegradability associated with the persistence in the environment for a long time turned the attention of researchers to natural polymers. Being biodegradable, biopolymers proved to be extremely beneficial to the environment. At present, they represent an important class of materials with applications in all economic sectors, but also in medicine. They find applications as absorbers, cosmetics, controlled drug delivery, tissue engineering, etc. Chitosan is one of the natural polymers which raised a strong interest for researchers due to some exceptional properties such as biodegradability, biocompatibility, nontoxicity, non-antigenicity, low-cost and numerous pharmacological properties as antimicrobial, antitumor, antioxidant, antidiabetic, immunoenhancing. In addition to this, the free amino and hydroxyl groups make it susceptible to a series of structural modulations, obtaining some derivatives with different biomedical applications. This review approaches the physico-chemical and pharmacological properties of chitosan and its derivatives, focusing on the antimicrobial potential including mechanism of action, factors that influence the antimicrobial activity and the activity against resistant strains, topics of great interest in the context of the concern raised by the available therapeutic options for infections, especially with resistant strains.

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Section: Pharmacological Potential Of Chitosan and Its Derivatives Applications In Current Pharmacotherapymentioning

confidence: 99%

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

et al. 2021

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“…Another strategy for antibacterial therapies involves developing polymeric nanoparticles as nanocarriers of both antibiotic drugs and alternative biocompounds. For example, de Oliveira et al developed polymeric nanoparticles consisting of chitosan and hydroxypropylmethylcellulose to administer the ceftriaxone antibiotic and S. brasiliensis extract in antibacterial therapies [ 128 ].…”

Section: Antimicrobial Applications Of Polymeric Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

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Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

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“…Several natural drugs have already been approved for clinical use, namely for antioxidant and antimicrobial purposes [178,179]. Notwithstanding, their combination as organic particles has also been object of several studies, while emphasizing their antioxidant [158,204,205] and antimicrobial capabilities [204,206,207]. If loaded into CS-based nano-or micro-scale organic particles [115], plant extracts hold the power to confer strong and long-lasting effects, without the consequences of overdose-induced tissue damage or inefficiency due to drug biodegradation ahead of reaching the target site.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

et al. 2021

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Marine-derived chitosan (CS) is a cationic polysaccharide widely studied for its bioactivity, which is mostly attached to its primary amine groups. CS is able to neutralize reactive oxygen species (ROS) from the microenvironments in which it is integrated, consequently reducing cell-induced oxidative stress. It also acts as a bacterial peripheral layer hindering nutrient intake and interacting with negatively charged outer cellular components, which lead to an increase in the cell permeability or to its lysis. Its biocompatibility, biodegradability, ease of processability (particularly in mild conditions), and chemical versatility has fueled CS study as a valuable matrix component of bioactive small-scaled organic drug-delivery systems, with current research also showcasing CS’s potential within tridimensional sponges, hydrogels and sutures, blended films, nanofiber sheets and fabric coatings. On the other hand, renewable plant-derived extracts are here emphasized, given their potential as eco-friendly radical scavengers, microbicidal agents, or alternatives to antibiotics, considering that most of the latter have induced bacterial resistance because of excessive and/or inappropriate use. Loading them into small-scaled particles potentiates a strong and sustained bioactivity, and a controlled release, using lower doses of bioactive compounds. A pH-triggered release, dependent on CS’s protonation/deprotonation of its amine groups, has been the most explored stimulus for that control. However, the use of CS derivatives, crosslinking agents, and/or additional stabilization processes is enabling slower release rates, following extract diffusion from the particle matrix, which can find major applicability in fiber-based systems within ROS-enriched microenvironments and/or spiked with microbes. Research on this is still in its infancy. Yet, the few published studies have already revealed that the composition, along with an adequate drug release rate, has an important role in controlling an existing infection, forming new tissue, and successfully closing a wound. A bioactive finishing of textiles has also been promoting high particle infiltration, superior washing durability, and biological response.

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Polymeric Nanoparticle Associated with Ceftriaxone and Extract of Schinopsis Brasiliensis Engler against Multiresistant Enterobacteria

Cited by 18 publications

References 63 publications

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

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