Polymeric nanoparticles wrapped in biological membranes for targeted anticancer treatment

Bigaj-Józefowska, Magdalena J.; Grześkowiak, Bartosz F.

doi:10.1016/j.eurpolymj.2022.111427

Cited by 20 publications

(6 citation statements)

References 150 publications

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“…Polydopamine (PDA) is a nature-inspired polymer that gained exceptional attention in chemistry due to its unique adhesive properties and multiple surface functionalization ability . A relatively simple synthesis can produce various forms of this material or its analogues, − that is, directly deposited coatings, , functional nanoparticles, − or free-standing films from the air/water interface. − The latter is particularly interesting due to the self-assembly of PDA macromolecules at the interface, leading to high-quality nanometric-thin polymer films that can be transferred to various functional substrates …”

Section: Introductionmentioning

confidence: 99%

Control of Intermolecular Interactions toward the Production of Free-Standing Interfacial Polydopamine Films

Szewczyk

Babačić

Krysztofik

et al. 2023

ACS Appl. Mater. Interfaces

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Aggregation of the polydopamine (PDA) molecular building blocks at the air/water interface leads to obtaining large surface nanometric-thin films. This mechanism follows two possible pathways, namely, covalent or non-covalent self-assembly, which result in a different degree of structure order and, consequently, different structural properties. Control of this mechanism could be vital for applications that require true self-support PDA free-standing films, for example, electrochemical sensing or membrane technology. Here, we are considering the impact of boric acid (BA) and Cu2+ ions on the mentioned mechanism exclusively for the free-standing films from the air/water interface. We have employed and refined our own spectroscopic reflectometry method to achieve an exceptionally high real-time control over the thickness growth. It turned out that BA and Cu2+ ions significantly impact the film growth process. Reduction of the nanoparticles size and their number was examined via UV–vis spectroscopy and transmission electron microscopy, showing a colossal reduction in the mean diameter of nanoparticles in the case of BA and a moderate reduction in the case of Cu2+. This modification is leading to significant enhancement of the process efficiency through moderation of the topological properties of the films, as revealed by atomic force microscopy. Next, applying infrared, Raman, and X-ray photoelectron spectroscopy, we presented small amounts of metal (B or Cu) in the final structure of PDA and simultaneously their vital role in the oxidation mechanism and cross-linking through covalent or non-covalent bonds. Therefore, we revealed the possibility of synthesizing films via the expected self-assembly mechanism which has hitherto been out of control. Moreover, modification of mechanical properties toward exceptionally elastic films through the BA-assisted synthesis pathway was shown by achieving Young’s modulus value up to 24.1 ± 5.6 and 18.3 ± 6.4 GPa, using nanoindentation and Brillouin light scattering, respectively.

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Section: Introductionmentioning

confidence: 99%

Control of Intermolecular Interactions toward the Production of Free-Standing Interfacial Polydopamine Films

Szewczyk

Babačić

Krysztofik

et al. 2023

ACS Appl. Mater. Interfaces

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“…When therapeutic compounds are transported by PNPs, their stability, bloodstream presence, and capacity to cross biological barriers are all reliably improved. 54…”

Section: Cell Membrane-coated Nps (Cmnps)mentioning

confidence: 99%

Cell membrane-coated biomimetic nanomedicines: productive cancer theranostic tools

Ijaz,

Aslam,

Hasan

et al. 2024

Biomater. Sci.

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“…Once enough source cells have been obtained, the membrane material is derived. For anucleate cells, hypotonic treatment or freeze-thaw cycles can be used to release intracellular contents, followed by high-speed centrifugation to form a pellet containing the membrane [ 91 ]. However, the process is more complex for nucleated cells, which require the separation of the plasma membrane from intracellular organelles and proteins.…”

Section: Preparation Of Membrane-coated Nanosystemsmentioning

confidence: 99%

“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review

et al. 2023

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Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versatile platform for the development of next-generation smart nanosystems. This review article presents an in-depth investigation into the potential of these nanosystems for targeted cancer theranostics, encompassing key aspects such as cell membrane sources, isolation techniques, nanoparticle core selection, approaches for coating nanoparticle cores with the cell membrane, and characterization methods. Moreover, this review underscores strategies employed to enhance the multi-functionality of these nanosystems, including lipid insertion, membrane hybridization, metabolic engineering, and genetic modification. Additionally, the applications of these bioinspired nanosystems in cancer diagnosis and therapeutics are discussed, along with the recent advances in this field. Through a comprehensive exploration of membrane-coated nanosystems, this review provides valuable insights into their potential for precise cancer theranostics.

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Polymeric nanoparticles wrapped in biological membranes for targeted anticancer treatment

Cited by 20 publications

References 150 publications

Control of Intermolecular Interactions toward the Production of Free-Standing Interfacial Polydopamine Films

Control of Intermolecular Interactions toward the Production of Free-Standing Interfacial Polydopamine Films

Cell membrane-coated biomimetic nanomedicines: productive cancer theranostic tools

“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review

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