Polymeric Nanoparticulate Systems: A Potential Approach for Ocular Drug Delivery

Godse, Rutika; Singh, Kavita; Shrivastava, Agnivesh; Shinde, Ujwala A.

doi:10.1007/978-3-319-29346-2_16

Cited by 7 publications

(2 citation statements)

References 147 publications

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“…The FDA-approved non-ionic surfactant D-alpha-tocopheryl polyethylene glycol succinate (TPGS), one of the functional materials used to modify the liposome surface, is being used more frequently because of its biocompatibility, lack of toxicity, adaptability to different administration routes, and capacity to improve solubilization, stability, penetration, and overall pharmacokinetics [ 120 ]. The TPGS-modified nanocarriers may improve drug absorption by passively increasing trans-corneal permeability of ocular drugs or by lowering P-gp-mediated efflux and enhancing drug stability [ 121 , 122 ]. Jin et al developed TPGS-modified nano-liposomes to deliver brinzolamide to the eye for glaucoma therapy [ 123 ].…”

Section: Functionalization Of Vesicular Systemsmentioning

confidence: 99%

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Batur,

Özdemir,

Durgun

et al. 2024

Pharmaceuticals

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Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off-target effects. In recent years, vesicular drug delivery systems have emerged as promising solutions to address these challenges. Vesicular systems, such as liposome, niosome, ethosome, transfersome, and others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, and spanlastics), offer several advantages for ocular drug delivery. These include improved drug bioavailability, prolonged retention time on the ocular surface, reduced systemic side effects, and protection of drugs from enzymatic degradation and dilution by tears. Moreover, vesicular formulations can be engineered for targeted delivery to specific ocular tissues or cells, enhancing therapeutic efficacy while minimizing off-target effects. They also enable the encapsulation of a wide range of drug molecules, including hydrophilic, hydrophobic, and macromolecular drugs, and the possibility of combination therapy by facilitating the co-delivery of multiple drugs. This review examines vesicular drug delivery systems, their advantages over conventional drug delivery systems, production techniques, and their applications in management of ocular diseases.

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Section: Functionalization Of Vesicular Systemsmentioning

confidence: 99%

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Batur,

Özdemir,

Durgun

et al. 2024

Pharmaceuticals

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“…Many PEG and TPGS-based nanocarriers have been designed for ocular delivery of therapeutic molecules, including NPs [162,163], micelles [164] and solid lipid NPs [165]. The TPGS-modified nanocarriers may enhance the trans-corneal permeability of ocular drugs either passively or by reducing P-gp mediated efflux resulting in improved drug absorption [166]. TPGS-modified nanocarriers could also enhance drug stability, which prevents drug loss from formulations [167].…”

Section: Ocular Deliverymentioning

confidence: 99%

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems

Farooq

Trevaskis

2022

Pharm Res

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Liposomes are sphere-shaped vesicles that can capture therapeutics either in the outer phospholipid bilayer or inner aqueous core. Liposomes, especially when surface-modified with functional materials, have been used to achieve many benefits in drug delivery, including improving drug solubility, oral bioavailability, pharmacokinetics, and delivery to disease target sites such as cancers. Among the functional materials used to modify the surface of liposomes, the FDA-approved non-ionic surfactant D-alpha-tocopheryl polyethylene glycol succinate (TPGS) is increasingly being applied due to its biocompatibility, lack of toxicity, applicability to various administration routes and ability to enhance solubilization, stability, penetration and overall pharmacokinetics. TPGS decorated liposomes are emerging as a promising drug delivery system for various diseases and are expected to enter the market in the coming years. In this review article, we focus on the multifunctional properties of TPGS-coated liposomes and their beneficial therapeutic applications, including for oral drug delivery, vaccine delivery, ocular administration, and the treatment of various cancers. We also suggest future directions to optimise the manufacture and performance of TPGS liposomes and, thus, the delivery and effect of encapsulated diagnostics and therapeutics.

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Bioengineered and Regenerative Medicine Strategies for Retina Repair

Delplace

Payne

et al. 2018

Regenerative Medicine and Stem Cell Therapy for the Eye

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Polymeric Nanoparticulate Systems: A Potential Approach for Ocular Drug Delivery

Cited by 7 publications

References 147 publications

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems

Bioengineered and Regenerative Medicine Strategies for Retina Repair

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