Polymeric nanostructured materials for biomedical applications

Tang, Zhaohui; He, Chaoliang; Tian, Huayu; Ding, Jianxun; Hsiao, Benjamin S.; Chu, Benjamin; Chen, Xuesi

doi:10.1016/j.progpolymsci.2016.05.005

Cited by 307 publications

(164 citation statements)

References 558 publications

(553 reference statements)

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“…The PEG coating on our QDs has been shown repeatedly to be the most highly non-interacting polymer coating for cellular environments. 21, 33 We demonstrate that heterogeneity in the actin network either manifested by cell type or by disruption of cytoarchitecture within healthy cell types results in a change in nanoparticle dynamics thus signifying that the cytoskeleton organization can act as a barrier for non-motor driven intracellular trafficking.…”

Section: Introductionmentioning

confidence: 87%

Intracellular nanoparticle dynamics affected by cytoskeletal integrity

et al. 2017

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The cell interior is a crowded chemical space, which limits the diffusion of molecules and organelles within the cytoplasm, affecting the rates of chemical reactions. We provide insight into the relationship between non-specific intracellular diffusion and cytoskeletal integrity. Quantum dots entered the cell through microinjection and their spatial coordinates were captured by tracking their fluorescence signature as they diffused within the cell cytoplasm. Particle tracking revealed significant enhancement in the mobility of biocompatible quantum dots within fibrosarcoma cells versus their healthy counterparts, fibroblasts, as well as in actin destabilized fibroblasts versus untreated fibroblasts. Analyzing the displacement distributions provided insight into how the heterogeneity of the cell cytoskeleton influences intracellular particle diffusion. We demonstrate that intracellular diffusion of non-specific nanoparticles is enhanced by disrupting the actin network, which has implications for drug delivery efficacy and trafficking.

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Section: Introductionmentioning

confidence: 87%

Intracellular nanoparticle dynamics affected by cytoskeletal integrity

et al. 2017

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“…In particular, we highlight recent studies relating nanostructured polymer surfaces, represented by synthetic amorphous homopolymers, semicrystalline polymers, and block copolymers, and their ability to control the conformation and selectivity of protein adsorption. We have not included a discussion on 3D polymeric nanostructured materials, as this topic was recently covered in depth by Tang et al [20] …”

Section: Introductionmentioning

confidence: 99%

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces

Firkowska‐Boden

Zhang

Jandt

2017

Adv Healthcare Materials

105

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The initial host response to healthcare materials' surfaces after implantation is the adsorption of proteins from blood and interstitial fluids. This adsorbed protein layer modulates the biological/cellular responses to healthcare materials. This stresses the significance of the surface protein assembly for the biocompatibility and functionality of biomaterials and necessitates a profound fundamental understanding of the capability to control protein–surface interactions. This review, therefore, addresses this by systematically analyzing and discussing strategies to control protein adsorption on polymeric healthcare materials through the introduction of specific surface nanostructures. Relevant proteins, healthcare materials' surface properties, clinical applications of polymer healthcare materials, fabrication methods for nanostructured polymer surfaces, amorphous, semicrystalline and block copolymers are considered with a special emphasis on the topographical control of protein adsorption. The review shows that nanostructured polymer surfaces are powerful tools to control the amount, orientation, and order of adsorbed protein layers. It also shows that the understanding of the biological responses to such ordered protein adsorption is still in its infancy, yet it has immense potential for future healthcare materials. The review, which is—as far as it is known—the first one discussing protein adsorption on nanostructured polymer surfaces, concludes with highlighting important current research questions.

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“…Nowadays, nanostructured materials are extensively used in many technologies due to their specific chemical and physical properties [1][2][3][4]. Nickel/iron alloys have good mechanical, electrical, and magnetic properties and a high catalytic activity for some electrochemical reactions [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Microstructural Changes during Annealing on Thermoelectromotive Force and Resistivity of Electrodeposited Ni_85.8Fe_10.6W_1.4Cu_2.2 Alloy

Spasojević¹,

Maricic²,

Vuković³

et al. 2017

Journal of Nanomaterials

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Cu 2.2 alloy powder containing nanocrystals of an FCC-structured solid solution of iron, tungsten, and copper in nickel embedded in an amorphous matrix was electrodeposited from an ammonia citrate solution. The alloy exhibits thermal stability in the temperature range between 25 ∘ C and 150 ∘ C. Over the range 150−360 ∘ C, the alloy undergoes intense structural relaxation which considerably increases the electron density of states and, hence, its electrical conductivity. Less intense structural relaxation takes place at temperatures between 360 ∘ C and 420 ∘ C. In the temperature range of 420 ∘ C to 460 ∘ C, relatively more intense changes in the electron density of states at the Fermi level occur, as induced by the structural relaxation resulting from the stabilization of larger less mobile tungsten atoms and copper atoms. The large decrease in electrical resistivity and the high increase in the electron density of states at the Fermi level in the temperature range 460−520 ∘ C are due to amorphous matrix crystallization and FCC-phase crystal grain growth.

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Polymeric nanostructured materials for biomedical applications

Cited by 307 publications

References 558 publications

Intracellular nanoparticle dynamics affected by cytoskeletal integrity

Intracellular nanoparticle dynamics affected by cytoskeletal integrity

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces

Effect of Microstructural Changes during Annealing on Thermoelectromotive Force and Resistivity of Electrodeposited Ni_85.8Fe_10.6W_1.4Cu_2.2 Alloy

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Polymeric nanostructured materials for biomedical applications

Cited by 307 publications

References 558 publications

Intracellular nanoparticle dynamics affected by cytoskeletal integrity

Intracellular nanoparticle dynamics affected by cytoskeletal integrity

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces

Effect of Microstructural Changes during Annealing on Thermoelectromotive Force and Resistivity of Electrodeposited Ni85.8Fe10.6W1.4Cu2.2 Alloy

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Product

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Effect of Microstructural Changes during Annealing on Thermoelectromotive Force and Resistivity of Electrodeposited Ni_85.8Fe_10.6W_1.4Cu_2.2 Alloy