Polymeric Scaffolds For Skin

Ruiz‐Velasco, Gabriela; Martínez‐Flores, Francisco; Morales-Corona, Juan; Olayo-Valles, Roberto; Olayo, Roberto

doi:10.1002/masy.201600133

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…Apparently, chronic wounds need specific treatment including tissue debridement, infection clearance, moisture balance, mechanical support, and management of comorbidities according to the etiology and real-time diagnosis. Wound dressings and skin tissue scaffolds are of great importance in wound care and skin tissue regeneration [27,160]. There have been developed plenty commercial products to fulfill the requirements for different wounds.…”

Section: Application Of Conductive Biomaterials In Wound Healingmentioning

confidence: 99%

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Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

2021

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Conductive biomaterials based on conductive polymers, carbon nanomaterials, or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity to human skin, good antioxidant and antibacterial activities, electrically controlled drug delivery, and photothermal effect. However, a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking. In this review, the design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized. The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies (electrotherapy, wound dressing, and wound assessment) were reviewed. The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound (infected wound and diabetic wound) and for wound monitoring is discussed in detail. The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well.

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Section: Application Of Conductive Biomaterials In Wound Healingmentioning

confidence: 99%

“…Wound dressings and skin tissue scaffolds are of great importance in wound care and skin tissue regeneration [ 27 , 160 ]. There have been developed plenty commercial products to fulfill the requirements for different wounds.…”

Section: Application Of Conductive Biomaterials In Wound Healingmentioning

confidence: 99%

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

2021

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“…A successful skin tissue scaffold should meet the following requirements: wound biocompatibility, cell adhesivity, porosity for tissue cell ingrowth and proliferation, suitable mechanical property, and biodegradability [1,12]. Many types of skin replacement have been developed in recent decades [1], fabricated either from natural purified polymers, such as collagen, gelatine (denatured collagen), fibrin, glycosaminoglycans, chitosan, alginate, or from synthetic polymers, including poly(glycolic acid) (PGA), poly(L lactic acid) (PLLA), polycaprolactone (PCL), polyethylene glycol (PEG), and polyvinyl alcohol (PVA) [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Fibrin/Polyvinyl Alcohol Scaffolds for Skin Tissue Engineering via Emulsion Templating

et al. 2023

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In the search for a novel and scalable skin scaffold for wound healing and tissue regeneration, we fabricated a class of fibrin/polyvinyl alcohol (PVA) scaffolds using an emulsion templating method. The fibrin/PVA scaffolds were formed by enzymatic coagulation of fibrinogen with thrombin in the presence of PVA as a bulking agent and an emulsion phase as the porogen, with glutaraldehyde as the cross-linking agent. After freeze drying, the scaffolds were characterized and evaluated for biocompatibility and efficacy of dermal reconstruction. SEM analysis showed that the formed scaffolds had interconnected porous structures (average pore size e was around 330 µm) and preserved the nano-scale fibrous architecture of the fibrin. Mechanical testing showed that the scaffolds’ ultimate tensile strength was around 0.12 MPa with an elongation of around 50%. The proteolytic degradation of scaffolds could be controlled over a wide range by varying the type or degree of cross-linking and by fibrin/PVA composition. Assessment of cytocompatibility by human mesenchymal stem cell (MSC) proliferation assays shows that MSC can attach, penetrate, and proliferate into the fibrin/PVA scaffolds with an elongated and stretched morphology. The efficacy of scaffolds for tissue reconstruction was evaluated in a murine full-thickness skin excision defect model. The scaffolds were integrated and resorbed without inflammatory infiltration and, compared to control wounds, promoted deeper neodermal formation, greater collagen fiber deposition, facilitated angiogenesis, and significantly accelerated wound healing and epithelial closure. The experimental data showed that the fabricated fibrin/PVA scaffolds are promising for skin repair and skin tissue engineering.

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“…Surface modification can be accomplished by depositing a polymeric thin film that has functional groups that allow biomolecules to anchor to the surface (Ramírez-Fernández et al, 2012;Zuñiga Aguilar et al, 2014). Plasma polymerization using pyrrole as monomer has shown reliable performance in producing surfaces that promote cell adhesion and proliferation, especially in in vivo experiments (Ramírez-Fernández et al, 2015;Ruiz Velasco et al, 2017). Electrospun PHB has been treated by plasma to improve its biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Plasma Functionalized Scaffolds of Polyhydroxybutyrate Electrospun Fibers for Pancreatic Beta Cell Cultures

et al. 2021

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Fibrous scaffolds based on biodegradable and biocompatible polyhydroxybutyrate (PHB) were produced by electrospinning. The scaffolds were coated by a thin solid film of polypyrrole, PPyI, deposited by plasma polymerization technique. FTIR and Raman spectroscopy results confirm the presence of PPyI on the PHB fibers, in FTIR can be show the signal of the NH2 groups characteristic of the polypyrrole, so Raman show a broad band due to fluorescence from the PPyI coating. The morphology of the scaffolds was characterized by scanning electron microscopy, and the average fiber diameter of PHB is (2.68 ± 1.69) μm, also the average fibers diameter of PHB-PPyI is (3.57 ± 1.36) μm, the comparation of the average fibers diameter of coated and uncoated indicates that the average PPyI coated thickness is 0.45 μm. Crystallinity of the PHB fibers was characterized by X-ray diffraction and differential scanning calorimetry, the degree of crystallinity is estimated at 70%. Pancreatic beta cells (from the RIN-M cell line) were cultured on PHB and PHB-PPyI scaffolds. Cell viability results showed that the surface modified material is a good cell culture substrate for beta cells.

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Polymeric Scaffolds For Skin

Cited by 8 publications

References 8 publications

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Fabrication of Fibrin/Polyvinyl Alcohol Scaffolds for Skin Tissue Engineering via Emulsion Templating

Plasma Functionalized Scaffolds of Polyhydroxybutyrate Electrospun Fibers for Pancreatic Beta Cell Cultures

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