Polymers and drugs suitable for the development of a drug delivery drainage system in glaucoma surgery

Löbler, Marian; Sternberg, Katrin; Stachs, Oliver; Allemann, Reto; Grabow, Niels; Roock, Anne; Kreiner, C. F.; Streufert, D.; Neffe, Axel T.; Hanh, Bui Duc; Lendlein, Andreas; Schmitz, Klaus‐Peter; Guthoff, Rudolf

doi:10.1002/jbm.b.31826

Cited by 26 publications

(22 citation statements)

References 25 publications

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“…Löbler et al 33 developed a device based in polyhydroxyalkanoates (PHA) for implantation of a glaucoma drainage system. In this study, polyhydroxyalkanoates (PHA) based on hydroxybutyric acid were tested in terms of their potential suitability to manufacture mechanically stable tube components of drug delivery drainage systems and in terms of biocompatibility.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of sodium diclofenac release using natural rubber latex as carrier

et al. 2014

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Sodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release time of diclofenac in a NRL membrane in vitro was increased from the typical 2-3 h for oral tablets to ca. 74 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 0.899 and 32.102 h. In this study, we demonstrated that the interesting properties provided by NRL membranes combined with a controlled release of drug is relevant for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Evaluation of sodium diclofenac release using natural rubber latex as carrier

et al. 2014

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“…Several previous studies on anti-glaucomatous valves have also employed rabbit eyes to assess efficacy and safety parameters (14)(15)(16). The sustained decrease in IOP scores and increase in AO detected on all postoperative intervals at the operated eyes, compared with preoperative IOP scores, implies that the IPI is effective in reducing the IOP.…”

Section: Discussionmentioning

confidence: 99%

Intra-Scleral Parathalamus Implant: Efficacy and Safety in Rabbit Eyes

Detorakis

Loggaki

Karyotakis

et al. 2014

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary:Purpose: A variety of anti-glaucomatous shunt designs have been proposed so far. This study evaluates the feasibility of a novel shunt design, the intra-scleral parathalamus implant (IPI), in a rabbit eye model. Methods: Ten healthy albino rabbits were included. Measurements of the IOP, using TonoPenXL, as well as ocular rigidity (OR) and aqueous outflow facility (AO), using a previously described methodology, were performed in both eyes of each animal. Subsequently, the IPI was implanted at the left eye of all animals whereas the right eye served as control. Measurements of IOP were repeated at weekly intervals for 2 months postoperatively whereas measurements of OR and AO were repeated at the 1st and 2nd postoperative week. Results: The IOP decreased significantly whereas the AO increased significantly postoperatively at the operated eyes. A significant postoperative decrease in OR was also recorded at the operated eyes. Respective differences at the fellow eyes were statistically not significant. Two animals developed postoperative complications and were excluded from follow-up. Conclusions: Results imply that the implantation of the IPI is feasible in rabbit eyes with significant favorable effects on the IOP, AO and OR.

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“…The rate of liberation shown is proximal of the rate observed in this study, which indicates that crystalline drugs have some difficulty to be liberated from NRL films, probably because of the intramolecular interaction between the latex and the drug. Several studies has been done in the drug delivery area using different materials, like Lober et al [16] that created a device based on polyhydroxyalkanoates for implantation of a glaucoma drainage system. Wang et al [17] prepared uniform chitosan microspheres by film emulsification technique to work as drug delivery system of a protein called BSA.…”

Section: Time (Min)mentioning

confidence: 99%

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

Bolognesi¹,

Borges²,

Cinman³

et al. 2015

ACSJ

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In order to create a new sustained drug delivery system applied for tissue regeneration, this study beget a natural rubber latex (NRL) film with Casearia sylvestris extract and ciprofloxacin. Manipulated from the biomaterial latex obtained by the rubber tree Hevea brasiliensis, the NRL film has shown to be a great angiogenic compound and also has shown a great potential in being a possible carrier for sustained drug release. In order to increase the therapeutic spectrum of the film two substances was added to it: the C. sylvestris extract which has antiulcer, anti-inflammatory and Bolognesi et al.; ACSj, 5(1): 17-25, 2015; Article no. ACSj.2015.003 18 wound healing effects due to its casearins and the antibiotic ciprofloxacin which is considered as one of the main drugs used for open wounds in the skin. The study occurred at State São Paulo University in Assis (UNESP-FCL), Brazil. The substances were mixed and a film was made by casting at ambient temperature creating circular films with 5cm of diameter. After that the film was placed in 1 liter of water to start the release study. The release behavior was analyzed by UV-VIS spectrophotometry being the casearins related to the wavelength of 235nm and the ciprofloxacin of 320nm. The film supported the release of compounds, releasing 93.73% of the extract and 56.53% of the drug, along 29 hours. In addition, the incorporation was proven by Scanning Electron Microscopy (SEM), which showed the morphology of pure and incorporated films and also by Fourier Transform Infrared Spectroscopy (FTIR) which has shown that no chemical change occurred during the process. Thereby, according to results, the material has a possible approach to biomedical application. Original Research Article

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Polymers and drugs suitable for the development of a drug delivery drainage system in glaucoma surgery

Cited by 26 publications

References 25 publications

Evaluation of sodium diclofenac release using natural rubber latex as carrier

Evaluation of sodium diclofenac release using natural rubber latex as carrier

Intra-Scleral Parathalamus Implant: Efficacy and Safety in Rabbit Eyes

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

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