Polymers and their engineered analogues for ocular drug delivery: Enhancing therapeutic precision

Biswas, Arpon; Kumar, Shivansh; Choudhury, Abhijit Deb; Bisen, Amol Chhatrapati; Sanap, Sachin Nashik; Agrawal, Sristi; Mishra, Anjali; Verma, Sarvesh Kumar; Kumar, Mukesh; Bhatta, Rabi Sankar

doi:10.1002/bip.23578

Cited by 6 publications

(1 citation statement)

References 227 publications

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“…Finally, RTGA (regenerating agent) are the biochemically engineered decomposable polymer mimics to heparan sulfate activity, which promotes matrix and growth factor synthesis in wounded tissues. These agents are recommended to combine with first line treatment to synergise the healing rate and quick recovery. − …”

Section: Treatment and Therapeutic Intervention For Fkmentioning

confidence: 99%

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Bisen,

Sanap,

Agrawal

et al. 2024

ACS Infect. Dis.

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Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that is prevalent in tropical countries, particularly in developing regions of Asia and Africa. Factors like corneal lens misuse, inappropriate steroid use, and diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, and ocular deformities. Accurate pathological diagnosis is crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves effective in preventing fungal-borne ulcers. Managing FK requires a comprehensive understanding of fungal pathogenesis, guiding formulation strategies and preventive measures to curb global ocular blindness. This review provides in-depth insights into FK, covering etiology, epidemiology, pathogenesis, therapeutic interventions, antifungal resistance, limitations, prevention, and future perspectives on ocular surface disease management.

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Section: Treatment and Therapeutic Intervention For Fkmentioning

confidence: 99%

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Bisen,

Sanap,

Agrawal

et al. 2024

ACS Infect. Dis.

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Pharmacokinetic Analysis of Gatifloxacin and Dexamethasone in Rabbit Ocular Biofluid Using a Sensitive and Selective LC–MS/MS Method

Biswas,

Choudhury,

Mishra

et al. 2024

J Mass Spectrom

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Bacterial keratitis (BK) is an infection that causes inflammation of the cornea and, if severe, can result in blindness. Topical fluoroquinolones combined with corticosteroids have been shown to be useful in the treatment of BK. A rapid, selective, and sensitive bioanalytical method for simultaneous quantification of Gatifloxacin (GAT) and Dexamethasone (DEX) has been developed and validated using tandem mass spectrometry (LC–MS/MS). Optimal separation was accomplished in under 5 min using an Agilent Zorbax C18 column (100 mm × 4.6 mm, 3.5 μm). The mobile phase was composed of a blend of 0.2% formic acid in triple distilled water and methanol with a flow rate of 0.65 mL/min in isocratic mode. GAT and DEX were detected in positive electrospray ionization multiple reaction monitoring mode (MRM), and the retention time was found to be at 1.64 and 2.93 min, respectively. The linearity of GAT and DEX was found to be in the range of 1.56–400 ng mL−1 with good precision and accuracy. The method was validated according to USFDA regulatory guidelines. The validated method was effectively utilized for preclinical pharmacokinetic analysis of GAT and DEX in rabbit tear fluid following the topical application of a commercial formulation.

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