Polymersome–hydrogel composites with combined quick and long-term antibacterial activities

Abstract

Intrinsically antibacterial polymersomes loaded with antibiotics were incorporated into hydrogels, exhibiting quick and long-acting antibacterial activity.

Polymer Vesicles for Antimicrobial Applications

“…In addition, the H50 of the vesicle and polymer chains were 700 and 110 μg mL −1 , respectively, corresponding to a selectivity (the value of H50/MIC) toward bacteria and blood cells of 44 and 3.4, respectively, indicating the high antimicrobial activity and blood compatibility, as well as the great potential of the vesicles used in drug delivery while eliminating the inflammation at the focus of infection simultaneously. Later, the same group conducted systematic studies using antimicrobial polypeptide-polymer conjugates as building blocks to prepare antimicrobial vesicles and investigate their biomedical applications [54,[98][99][100][101]. For example, a folic acid labeled biodegradable PCL-polypeptide vesicle was prepared to inhibit bacteria and targeted drug delivery [54].…”

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

“…To circumvent these limitations, a diblock copolymer poly(ε‐caprolactone)‐ b ‐poly(lysine‐ stat ‐phenylalanine) [PCL‐ b ‐P(Lys‐ stat ‐Phe)] was synthesized via ring‐opening reaction and then self‐assembled into polymer vesicles for the encapsulation of penicillin to combat bacterial infections . The PCL blocks formed the hydrophobic bilayers of the polymer vesicles and rendered degradability under physiological condition.…”

“…Schematic illustration for the a) fabrication of hydrogel‐polymer vesicles composites and b) action mechanisms for the combination of quick and long‐term antibacterial capabilities. Reproduced with permission . Copyright 2018, Royal Society of Chemistry.…”

Polymersomes with inhomogeneous membranes, asymmetrical coronas and fused membranes and coronas

“…由传统嵌段共聚物自组装形成的囊泡具有膜冠分 明、功能离散的特点, 难以发挥膜冠协同效应 [51] . 图 7 (网络版彩色)由嵌段共聚物 [55] 、无规共聚物 [56] 和交替共聚物 [57] 自组装形成的阳离子抗菌囊泡、抗菌肽囊泡, 以及仿多肽抗菌囊泡(由左 至右). 随着膜冠融合程度的增加, 囊泡抗菌性和细胞相容性相应提高 Figure 7 (Color online) Antibacterial polymersomes self-assembled from block copolymer [55] , statistical copolymer [56] and alternating copolymer [57] (from left to right).…”

“…图 7 (网络版彩色)由嵌段共聚物 [55] 、无规共聚物 [56] 和交替共聚物 [57] 自组装形成的阳离子抗菌囊泡、抗菌肽囊泡, 以及仿多肽抗菌囊泡(由左 至右). 随着膜冠融合程度的增加, 囊泡抗菌性和细胞相容性相应提高 Figure 7 (Color online) Antibacterial polymersomes self-assembled from block copolymer [55] , statistical copolymer [56] and alternating copolymer [57] (from left to right). As the degree of fusion between membrane and coronas increases, the antibacterial efficacy and cytocompatibility increases accordingly [65,66] 、催化 [66] 、电子元器件 [67] 等领域.…”