Polymersomes: Fundamentals and Shape Transformation Methods

Wong, Chin Ken; Lai, Rebecca Y.; Thordarson, Pall

doi:10.1002/9783527834044.ch38

Cited by 2 publications

(18 citation statements)

References 69 publications

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“…In general, methods for preparation of polypeptide NPs can be divided into two types: preparation of NPs from pre-synthesized polypeptides and polypeptide-containing copolymers or formation of NPs during polymerization of monomers [160,200,240]. The approach based on the use of pre-synthesized polypeptides is more popular due to the possibility of rigorous pre-purification and characterization of the (co)polymers utilized.…”

Section: Methods For Preparation Of Nanoparticles and Drug Nanoformul...mentioning

confidence: 99%

“…In turn, their analogs with an elongated hydrophilic polypeptide block, namely PB 48 -b-PGlu 114 , PB 48 -b-PGlu 145, and PB 48 -b-PLys 178 , formed micelles. Details on the mechanisms of polymersome self-assembly as well as the methods of shape transformation can be found elsewhere [200].…”

Section: Polymersomesmentioning

confidence: 99%

“…One of the variants of slow nanoprecipitation is the method of gradient phase inversion, which is most conveniently realized in the format of dialysis [200,240]. As in the previous case, this method is mainly suitable for amphiphilic block-copolymers and random polypeptides, which are better solubilized in the organic phase than in the aqueous phase.…”

Section: Gradient Phase Inversion (Dialysis)mentioning

confidence: 99%

Section: Rehydration Of Filmsmentioning

confidence: 99%

“…Rehydration of the resulting film is carried out by adding a good solvent for the hydrophilic fragment of the polypeptide-containing copolymer (water or aqueous buffer solution) under careful stirring or gentle sonication. As a result, the formation of self-assembled NPs occurs (Figure 18) [200,261]. This technique is suitable for amphiphilic copolymers with a pronounced hydrophobic moiety, making them better soluble in organic solvents than in water.…”

Section: Rehydration Of Filmsmentioning

confidence: 99%

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Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Stepanova,

Nikiforov,

Tennikova

et al. 2023

Pharmaceutics

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Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels. The issues, such as the diversity of polypeptide-containing (nano)particle types, the methods for their preparation and drug loading, as well as the influence of physicochemical characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, and immunogenicity of polypeptide-containing nanoparticles and their drug formulations, are comprehensively discussed. Finally, recent advances in the development of certain drug nanoformulations for peptides, proteins, gene delivery, cancer therapy, and antimicrobial and anti-inflammatory systems are summarized.

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Section: Methods For Preparation Of Nanoparticles and Drug Nanoformul...mentioning

confidence: 99%

Section: Polymersomesmentioning

confidence: 99%

Section: Gradient Phase Inversion (Dialysis)mentioning

confidence: 99%

Section: Rehydration Of Filmsmentioning

confidence: 99%

Section: Rehydration Of Filmsmentioning

confidence: 99%

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Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Stepanova,

Nikiforov,

Tennikova

et al. 2023

Pharmaceutics

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Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

Zhang,

van Hest,

Men

2024

ACS Appl. Nano Mater.

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Polymersomes have been studied for many years since their discovery, and have consistently been an appealing and widely explored research domain. Their inherent benefits, encompassing stability, versatility, load-carrying capacity, and deformability, endow them with many opportunities to be used in numerous fields of biomedicine, nanocarriers, diagnostics and therapeutics. Nevertheless, shape transformation pathways have not been comprehensively summarized or received adequate scholarly attention. Herein, we summarize typical mechanisms underlying polymersome self-assembly with a particular focus on the shape transformation pathways associated with commonly employed self-assembling methods. Moreover, we provide a succinct overview of the proposed applications involving shape transformation applications, and enumerate the most recent findings in this domain.

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Polymersomes: Fundamentals and Shape Transformation Methods

Cited by 2 publications

References 69 publications

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

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