2018
DOI: 10.1038/s41477-018-0194-x
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Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen

Abstract: Accelerated adaptive evolution is a hallmark of plant-pathogen interactions. Plant intracellular immune receptors (NLRs) often occur as allelic series with differential pathogen specificities. The determinants of this specificity remain largely unknown. Here, we unravelled the biophysical and structural basis of expanded specificity in the allelic rice NLR Pik, which responds to the effector AVR-Pik from the rice blast pathogen Magnaporthe oryzae. Rice plants expressing the Pikm allele resist infection by blas… Show more

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Cited by 152 publications
(484 citation statements)
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“…S1). There was a weak response to the AVR-PikD H46E negative control, as previously observed, due to differences in the AVR-PikD His46 interface with Pikm-HMA compared with Pikp-HMA (12). This suggests that the weak cell death response to AVR-Pia is specific for the Pikp allele.…”
Section: Co-expression Of Pikp/avr-pia In Nicotiana Benthamiana Elicisupporting
confidence: 74%
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“…S1). There was a weak response to the AVR-PikD H46E negative control, as previously observed, due to differences in the AVR-PikD His46 interface with Pikm-HMA compared with Pikp-HMA (12). This suggests that the weak cell death response to AVR-Pia is specific for the Pikp allele.…”
Section: Co-expression Of Pikp/avr-pia In Nicotiana Benthamiana Elicisupporting
confidence: 74%
“…N. benthamiana is a well-established model system for assaying the response of rice NLRs to M. oryzae effectors (11,12,28). Therefore, we used this system to test whether Pik NLRs would show any response to the effector AVR-Pia.…”
Section: Co-expression Of Pikp/avr-pia In Nicotiana Benthamiana Elicimentioning
confidence: 99%
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