Polymorphic variants of the TLR6 gene in adult patients with bronchial asthma

Abstract

ПоЛИморФНЫЕ варИаНТЫ ГЕНа tlr6 У вЗроСЛЫХ ПаЦИЕНТов С БроНХИаЛЬНой аСТмой Л. ю. Барычева, Л. в. Шушанова, а. в. ягода, м. в. Голубева, м. м. минасян Ставропольский государственный медицинский университет, российская Федерация Immunogenetic studies were performed in 65 people with allergic bronchial asthma (BA) and 35 with non-allergic BA. This study established that the molecular genetic markers for an increased risk of allergic BA are allele TLR6 745C and TLR6 C745T. This association of polymorphic markers of the TLR6 gene is confirmed only for allergic BA. An increased risk of allergic asthma was found in carriers of the common allele TLR6 745C and those with the heterozygous genotype C745T.