Polymorphism and DNA methylation in the promoter modulate KISS1 gene expression and are associated with litter size in goats

An, Xiaopeng; Hou, Jinxing; Yue, Lei; Gao, Teyang; Cao, Binyun

doi:10.1016/j.anireprosci.2015.01.013

Cited by 19 publications

(11 citation statements)

References 29 publications

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“…Previous studies detected that many genetic mutations within candidate genes could affect goat litter size traits. The genetic polymorphism of KISS1 gene was explored and showed that four SNPs may affect litter size in goats (An et al, 2015a). Polymorphisms of GNRH1 and GDF9 genes were identified, and their association with litter size in goats was analyzed (An et al, 2013a).…”

Section: Discussionmentioning

confidence: 99%

“…For example, the goat INHA 651A/G polymorphism significantly affected the litter size in Boer goats (Wu et al, 2009). The polymorphism in the promoter region of the KISS1 gene has a notable correlation with the litter size (An et al, 2015a). Additionally, FTH1, growth hormone (GH), and serum amyloid A (SAA) genes were significantly associated with high litter size in Jining Grey goats (Feng et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

et al. 2018

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Abstract. The LIM homeobox transcription factor 4 (LHX4) gene plays a critical role in regulating the development of the pituitary and the secretion of growth hormone (GH) and prolactin (PRL) associated with reproduction. Thus this gene may affect litter size. Herein, the aim of this study is to detect the novel insertion/deletion (indel) within the LHX4 gene as well as to test its association with litter size in 1149 Shaanbei white cashmere goats. Herein, a novel 12 bp indel (NC_030823.1:g.60001011_60001022delGGGGAGGAGGGG) was firstly found, which was located in the first intron. Meanwhile, three genotypes were detected in Shaanbei white cashmere goats, and the allelic frequencies of I and D were 0.593 and 0.407, respectively. Interestingly, the genotype distributions between mothers of single-lamb (n = 895) and multi-lamb (n = 254) groups within Shaanbei white cashmere goats were significantly different, implying that the 12 bp indel might affect the litter size. Furthermore, the association analysis was carried out to find out that the 12 bp indel was significantly associated with litter size in the analyzed goat population (P < 0.05). The litter sizes of genotype DD and ID individuals were superior to those of genotype II (P < 0.05). These findings suggest that this locus could be considered as a genetic marker for goat breeding, enriching the research category of functional genome of goats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

et al. 2018

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“…Their data showed that these functional binding sites in the intron 1 may influence E2F activation, and enhanced activation of E2F could at least in part increase the expression of NCOA3 gene [ 35 ]. Previous studies reported that gene polymorphisms may regulate gene expression by changing the binding sites of transcription factors, and may further be associated with specific phenotypes [ 39 , 40 ]. We suppose that intron 1 SNPs of NCOA3 may have potential effect on gene transcription.…”

Section: Discussionmentioning

confidence: 99%

Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population

Siame

et al. 2015

Lipids Health Dis

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BackgroundNuclear receptor coactivator-3 (NCOA3) is involved in various physiological processes. Emerging evidence from previous studies using animal models suggests that the NCOA3 gene (NCOA3) plays a critical role in lipid metabolism as well as adipogenesis and obesity. The present study aims to investigate the association between NCOA3 SNPs and dyslipidemia in the Chinese Han population.MethodsFive hundred and twenty-nine (529) Chinese Han subjects were recruited. Four tag SNPs (rs2425955G > T, rs6066394T > C, rs10485463C > G, and rs6094753G > A) in NCOA3, selected from the HapMap website, were genotyped using MALDI-TOF mass spectrometry. Data analysis was performed using SPSS 16.0, SNPStats and haploview 4.2.ResultsFour SNPs (rs2425955, rs6066394, rs10485463, and rs6094753) were associated with triglyceride levels. Except for SNP rs10485463, genotype distributions and allele frequencies of the other three NCOA3 SNPs (rs2425955, rs6066394, and rs6094753) were significantly different between hypertriglyceridemia subjects and normal group. Significant differences were also observed in allele frequencies and genotype distributions of SNP rs10485463 between low-HDL cholesterolemia subjects and normal group. Carriers of rs2425955 T allele had a lower risk of hypertriglyceridemia compared to GG genotype. Similar results were observed from rs6094753. Subjects with rs6066394 CT genotype had a lower risk of hypertriglyceridemia than those with the TT genotype; however, CC and TT genotypes showed no significant difference in the risk of hypertriglyceridemia. Similar results were found in the association between rs6066394 and hypercholesterolemia. The variant alleles of rs2425955, rs6066394 and rs6094753 were associated with a lower risk of hypertriglyceridemia compared with the wild-type alleles. The G allele of rs10485463 was associated with an increased risk of low-HDL cholesterolemia. In the log-additive model the association between rs2425955 and hypertriglyceridemia remained significant after Bonferroni correction, and genotypes with variant alleles were associated with a lower risk of hypertriglyceridemia.ConclusionsIn summary, this study demonstrated that variation in NCOA3 might influence the risk of dyslipidemia and serum lipid levels in Chinese Han population.

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“…Growth is an intricate biological process that comprises the regulated coordination of a wide diversity of neuro-endocrine pathways, including a coordinated action of several hormones (like growth, thyroxine, insulin, and prolactin hormones) secreted by the key endocrine glands and controlled by the action of their corresponding genes (Ge et al 2003;Rasouli et al 2016;An et al 2015;Othman et al 2014;Silveira et al 2008;Zhang et al 2013). It is well established that animals with high levels of these hormones exhibit enhanced growth performance (Jia et al 2014;Sodhi et al 2007;Sharma et al 2013;Amie Marini et al 2010;Ayuk and Sheppard 2006).…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of growth hormone gene in three goat breeds in Egypt

et al. 2018

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Background: In Egypt, like other developing countries, goats are prime resources of meat. So, selection of goats for superior growth rate is advantageous. Growth hormone (GH) is the main regulator of animal growth, and encoded by GH gene that exhibits active gene variants improving growth. The objective of this study was to identify GH gene variants in three goat breeds (Barki, Damascus, and Zaraibi), via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and gene sequencing analyses. Results: Three loci on GH gene named GH1, GH2, and GH6 polymorphisms were analyzed. GH1-HaeIII/RFLP showed only two genotypes (AB and BB) in all breeds, with absent AA genotype. Both Barki and Zaraibi exhibited the highest GC genotype frequency (0.95). GH2-HaeIII/RFLP produced only two homozygous genotypes AA in Damascus and BB in both Barki and Zaraibi, with the absence of AB genotype in the three breeds. However, digestion of GH6 by HaeIII was monomorphic; it exhibited different single-nucleotide polymorphisms (SNPs), detected by DNA sequencing, among the studied goat breeds. Conclusions: The revealed SNPs could be employed as useful markers, helping goat breeders in selection of goats for high growth performance. Further analyses with larger sample size are needed for investigating the relationship between the different genotypes and growth traits.

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Polymorphism and DNA methylation in the promoter modulate KISS1 gene expression and are associated with litter size in goats

Cited by 19 publications

References 29 publications

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population

Polymorphism of growth hormone gene in three goat breeds in Egypt

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Polymorphism and DNA methylation in the promoter modulate KISS1 gene expression and are associated with litter size in goats

Cited by 19 publications

References 29 publications

A novel 12 bp deletion within goat &lt;i&gt;LHX4&lt;/i&gt; gene significantly affected litter size

A novel 12 bp deletion within goat &lt;i&gt;LHX4&lt;/i&gt; gene significantly affected litter size

Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population

Polymorphism of growth hormone gene in three goat breeds in Egypt

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A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size

A novel 12 bp deletion within goat <i>LHX4</i> gene significantly affected litter size