Polymorphism and Solvatomorphism 2009

Polymorph Formation and Nucleation Mechanism of Tolfenamic Acid in Solution: An Investigation of Pre-nucleation Solute Association

“…On account of this, prediction and precise control of a specific polymorph are critical for achieving desired solubility and stability requirement. Recent efforts have been devoted to the development of consistent and reliable crystallization processes for producing desirable polymorphs, including on-line, spectroscopy-based monitoring designs of crystal growth in solution (3)(4)(5). Polymorphic formation is known to be affected by a wide variety of growth conditions, such as type of solvent (6)(7)(8), supersaturation (4,9), temperature (10), and use of additives (11,12).…”

Thermal Behavior of Benzoic Acid/Isonicotinamide Binary Cocrystals

“…2 Hydrates and solvates have additionally received much attention. 3 Co-crystals, in which the neutral API is combined with a neutral co-former in a single crystalline phase, have been shown to be capable of improving physical, mechanical, dissolution and bioavailability properties for a range of APIs. 4 For instance, the hygroscopicity of theophylline can be reduced through forming co-crystals with oxalic acid.…”

Conformational Polymorphism on Imatinib Mesylate: Grinding Effects

“…7 Some illuminating examples of conversions such as described above can be found in literature. 8,9 For example, the milling process of cimetidine enables conversions of forms B and C to form A, whereas form A transforms into form D only upon nucleation. In all cases, the particle size reduction step resulted in substantial formation of an amorphous phase.…”