Polymorphism in exon 3 of myostatin ( MSTN ) gene and its association with growth traits in Indian sheep breeds

Sahu, Amiya Ranjan; Jeichitra, V.; Rajendran, R.; Amri, R.

doi:10.1016/j.smallrumres.2017.01.009

Cited by 13 publications

(5 citation statements)

References 11 publications

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“…The inability to find any association of weaning and body weight with the polymorphic status of the MSTN gene in the present study might be due to the breed-specific effect of the locus under study. This study in line with (Sahu et al 2017) which mentioned that, a non-significant effect of this mutation that observed on birth, weaning (three months) and six months weight in Indian Mecheri and Madras Red sheep. (Sumantri et al 2008) reported that genetic diversity based on molecular marker MSTN c.del960G locus in Indonesia local sheep are very low.…”

Section: Discussionsupporting

confidence: 84%

Short Communication: Polymorphism at third exon of the Myostatin gene and its association with growth and carcass traits in Batur sheep

et al. 2020

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Abstract. Haren HIH, Purwantini D, Sumaryadi MY, Prayitno. 2020. Short Communication: Polymorphism at third exon of the Myostatin gene and its association with growth and carcass traits in Batur sheep. Biodiversitas 21: 2074-2078. The present study aimed to investigate the association between myostatin (MSTN) genotype and two traits, growth and carcass, in Batur sheep. Blood samples representing thirty head were collected and genomic DNA was extracted. A specific primer designed to amplify the MSTN gene, samples sequenced then, used the BioEdit program to identify any mutation. Calculation of genotypes, gene and allele frequencies, heterozygosities, and Chi-square test was performed. Only two alleles observed (G and C) resulted in three genotypes. 11 polymorphic sites were observed, transversion at c.*121G>C, and one individual G>A which disrupted reading frame of whole MSTN sequenced, genotypic and allelic frequencies were 0.552 GG, 0.379 GC, and 0.069 CC, where the allele frequency was 0.741 G and 0.259 C. Lambs that carrying genotype GC had slightly more pre-slaughter weight, hot carcass weight, cold carcass weight, carcass length, and total yield (lion, shoulder, leg yield, and thigh) compared to those carrying genotype GG. There was no significant effect of the MSTN genotype on carcass traits (p=0.05). Polymorphic site c.*121 G>C is present in Batur sheep for the first time about the association with the MSTN gene however, it has not effects weaning weight, 6-month weight, and studied carcass traits.

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Section: Discussionsupporting

confidence: 84%

Short Communication: Polymorphism at third exon of the Myostatin gene and its association with growth and carcass traits in Batur sheep

et al. 2020

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“…MSTN gene serves as a negative regulator for muscle growth. Thus, muscle growth increases by double when the function of MSTN deteriorated in sheep [22,23]. The gene, growth hormone (GH) has been identified affecting post-weaning gain.…”

Section: Genes Associated With Growth and Body Weightmentioning

confidence: 99%

Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries)

Gebreselassie

Berihulay

Jiang

et al. 2019

Animals

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Simple Summary: Sheep is one of the most economically important animals used as a source of meat, milk, wool, and fur for human society. These commodities are essential for human being. Body growth, body weight, carcass quality, fat percent, fertility, milk yield, wool, horn type and coat color are essential and useful sheep traits. Understanding the genetic background of these traits is paramount to increase the production and productivity of domestic animals. The availability of genomic data, development of molecular breeding techniques, and genome technologies have come to play a vital role in understanding the genetic background of different animal traits. This is directly or indirectly helpful for the practice of genetic improvement of economically important traits in sheep. The identification of genomic regions, genes associated with phenotypic traits, and description of gene function are some of the applied research activities to understand the genetics of livestock species. The aim of this review is to discuss and summarize different reported research findings on identified genomic regions and candidate genes related with economically important traits as well as gene annotation in sheep.Abstract: Sheep (Ovis aries) is one of the most economically, culturally, and socially important domestic animals. They are reared primarily for meat, milk, wool, and fur production. Sheep were reared using natural selection for a long period of time to offer these traits. In fact, this production system has been slowing the productivity and production potential of the sheep. To improve production efficiency and productivity of this animal through genetic improvement technologies, understanding the genetic background of traits such as body growth, weight, carcass quality, fat percent, fertility, milk yield, wool quality, horn type, and coat color is essential. With the development and utilization of animal genotyping technologies and gene identification methods, many functional genes and genetic variants associated with economically important phenotypic traits have been identified and annotated. This is useful and presented an opportunity to increase the pace of animal genetic gain. Quantitative trait loci and genome wide association study have been playing an important role in identifying candidate genes and animal characterization. This review provides comprehensive information on the identified genomic regions and candidate genes associated with production and reproduction traits, and gene function in sheep.

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“…Some MSTN variants were also associated with muscle mass increase in Norwegian White Sheep (Boman et al, 2010), crossbreed lambs (Hope et al, 2013), and New Zealand sheep (Han et al, 2013). In addition, effects on birth weight in Makoei sheep (Farhadian et al, 2012), and body weight in Madras Red sheep (Sahu et al, 2017) were also reported. Therefore, knowing the polymorphisms in MyoD family genes and MSTN gene and their frequencies is the first step toward using them in association studies.…”

Section: Introductionmentioning

confidence: 93%

Polymorphisms in MyoD1, MyoG, MyF5, MyF6, and MSTN genes in Santa Inês sheep

Sousa

Meira

Azevedo

et al. 2019

Pesq. agropec. bras.

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The objective of this work was to sequence the MyoD1, MyoG, MyF5, MyF6, and MSTN genes and to identify polymorphisms in Santa Inês sheep (Ovis aries). A total of 192 lambs with 240 days of age were evaluated, and these genes were sequenced to be compared with the reference sequence in the Ovis aries genome. Genotype and allele frequencies were estimated, and the Hardy-Weinberg equilibrium was tested. Fragments containing 2,493 bp (MyoD1), 1,836 bp (MyoG), 2,813 bp (MyF5), 1,126 bp (MyF6), and 2,380 bp (MSTN) were obtained, and, in these sequences, 160 variants were identified. These polymorphisms were distributed as follows: 59 (MyoD1), 24 (MyoG), 63 (MyF5), 4 (MyF6), and 10 (MSTN). One hundred and four were novel polymorphisms, 45 in MyoD1, 2 in MyoG, 56 in MyF5, and 1 in MSTN. Regarding site, 61 were in intron (27 in MyoD1, 16 in MyoG, 5 in MyF5, 3 in MyF6, and 10 in MSTN), 87 in coding region (22 in MyoD1, 8 in MyoG, 56 in MyF5, and 1 in MyF6), and 12 on 3’UTR (10 in MyoD1 and 2 in MyF5). Therefore, the MyoD family and MSTN genes have several polymorphisms in Santa Inês sheep, which can be useful for association studies.

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Polymorphism in exon 3 of myostatin ( MSTN ) gene and its association with growth traits in Indian sheep breeds

Cited by 13 publications

References 11 publications

Short Communication: Polymorphism at third exon of the Myostatin gene and its association with growth and carcass traits in Batur sheep

Short Communication: Polymorphism at third exon of the Myostatin gene and its association with growth and carcass traits in Batur sheep

Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries)

Polymorphisms in MyoD1, MyoG, MyF5, MyF6, and MSTN genes in Santa Inês sheep

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