Polymorphism in folate cycle genes in patients with gout in the Russian population of Trans-Baikal Territory

Kushnarenko, N. N.; Mishko, M. Yu.; Medvedeva, T. A.

doi:10.29001/2073-8552-2020-35-1-142-150

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Клиническое значение суточного мониторирования артериального давления клинико-патогенетических взаимодействий повышенного уровня мочевой кислоты и АГ [5,6]. Действительно, повышение уровня мочевой кислоты сыворотки крови в результате воздействия внешнесредовых и генетических факторов способствует инициации иммуновоспалительных нарушений, окислительного стресса, циклооксигеназы-2, пролиферации эндотелия, гломерулотубулярного повреждения, формированию тубулоинтерстициального фиброза, нейрогуморальной активации, индуцирующих повышение артериального давления (АД) [7,8]. В свою очередь наличие АГ способствует утяжелению некоторых сопутствующих состояний -инсулинорезистентности, дислипидемии, хронической болезни почек, создавая порочный круг причинно-следственных взаимосвязей повышенного уровня уратов и развития подагры в будущем [5,9].…”

Section: Introductionunclassified

Clinical significance of 24-hour blood pressure monitoring in prediction of hypertension development in patients with gout

Губанова

Kushnarenko

Karavaeva

2021

SJCEM

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Aim. The aim of the study was to develop the model for establishing early diagnosis of hypertension in patients with gout. The model was based on data of 24-hour blood pressure monitoring.Material and Methods. A total of 69 patients with gout were enrolled in a single-stage cross-sectional prospective study. Three study groups were assigned as follows: group 1 (main group) comprised hypertensive men with gout (n = 41); group 2 (comparison group) comprised normotensive men with gout (n = 28); group 3 (control) included relatively healthy men (n = 30). Daily blood pressure monitoring was performed on an outpatient basis using a BPLab device (Peter Telegin, Russia).Results. The significant intergroup differences were found in the following parameters: lowest, mean, and highest 24-hour systolic blood pressure (SBP) values in patients of main and comparison groups (р < 0.001) and in patients of main and control groups (р < 0.001); mean and maximum 24-hour diastolic blood pressure (DBP) values in patients of main and comparison groups (р < 0.001) and in patients of main and control groups (р < 0.001); lowest, mean, and highest 24-hour pulse blood pressure (PBP) values in patients of main and comparison groups (р < 0.001) and in patients of main and control groups (р < 0.001); mean, and maximum 24-hour PBP values in patients of comparison and control groups (р < 0.001). Median values of the lowest, mean, and highest 24-hour SBP in hypertensive patients with gout were significantly higher than the corresponding values in normotensive patients with gout and healthy men of group 3 (p < 0.001). Median values of mean and maximum 24-hour DBP in main group were higher than the corresponding values in comparison group and control group (p < 0.001). Median values of the lowest, mean, and highest 24-hour PBP in hypertensive patients with gout exceeded the corresponding values of patients of control group (p < 0.001). Median values of the mean and maximum 24-hour PBP in main group exceeded the corresponding values of patients of comparison group (p < 0.001). Based on the binary logistic regression model, the prognostic algorithm for hypertension development in gout patients was created using the parameters of 24-hour blood pressure monitoring as predictors and the cut-off K value. If the value of K was > 0.54, then the hypertension development was predicted in gout patients. The sensitivity of developed diagnostic model was 0.84, and the specificity was 0.95.Conclusion. Тhe proposed model, based on the assessment of average-daily values of the lowest, mean, and highest SBP, allowed to establish early diagnosis of hypertension in patients with gout with the accuracy of up to 90%.

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Section: Introductionunclassified

Clinical significance of 24-hour blood pressure monitoring in prediction of hypertension development in patients with gout

Губанова

Kushnarenko

Karavaeva

2021

SJCEM

Self Cite

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Allelic variants of folate metabolism genes among students in Arctic Russia

Voronsova,

Vorobyeva,

Vorobyeva

et al. 2023

Ekologiya cheloveka (Human Ecology)

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AIM: analysis of epidemiology of the spread of polymorphism of folate metabolism genes in various ethnic groups Russians and Indians living in the Arctic region of Russia. METHODS: epidemiological, prospective, cross-sectional population study was performed on a sample of ethnic Indians and Russians, natives of the Arkhangelsk region.RESULTS: A questionnaire survey of participants and a molecular genetic study of genes determining folate metabolism were conducted by real-time PCR. During the study, the participants were divided into two groups a group of Russian ethnos and a group of Indian ethnos. A comparative analysis of the frequencies of the spread of polymorphism of folate metabolism genes in the two studied groups was carried out. CONCLUSION: russian participants were more likely to carry the unfavorable allele T polymorphism rs1801133 of the MTHFR gene in comparison with the group of ethnic Indians, which indicates an increased risk of folate metabolism disorders in the group of Russian participants.

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Assessment of antenatal risk factors for the formation of congenital defects of the development of the urinary system in children

Сергеева

Шуматова

et al. 2022

Medicinskij sovet

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Introduction. In the Russian Federation, the number of new cases of congenital malformations and chromosomal abnormalities reported among children from birth to 14 years of age each year is over 1,000 per 100,000 population. Therefore, the urgency of the problem of diagnosis and prevention of congenital malformations does not admit of doubt.Purpose of the study. To study the influence of antenatal risk factors on the formation of the urinary system’s congenital malformations in children.Materials and methods. The study carried out by the “case – control” method. The main group included 126 mothers who gave birth to children with kidney and urinary tract defects, and the control group included 40 women with healthy children. The assessment of the results reliability the obtained carried out by calculating the odds ratio with a 95% confidence interval.Results. The most significant factors in the formation of malformations of the urinary system were: the age of mothers over 35 years old (OR 3.264, 95% CI: 1.079–9.875), a burdened obstetric history (OR 2.380, 95% CI: 1.012–5.594), a burdened gynecological anamnesis (OR 2.825, 95% CI: 1.319–6.051), preeclampsia (OR 2.910, 95% CI: 1.057–8.010), exacerbation of opportunistic infections during pregnancy (OR 2.833, 95% CI: 1.103–7.280), the presence of chronic placental insufficiency (OR 3.413, 95% CI: 1.405–8.290), passive smoking during pregnancy (OR 2.711, 95% CI: 1.110–6.618), a burdened nephrological history in the mother (OR 3.462, 95% CI: 1.148–10.442), the presence of neurocirculatory dystonia (OR 4.703, 95% CI: 1.062–20.822). The work revealed the role of folate metabolism genes polymorphisms in the formation of kidney defects. In addition, a reliable relationship between the development of kidney and urinary tract defects with the absence of pregravid preparation was found, as well as untimely intake of folic acid preparations.Conclusions. The study made it possible to identify the most significant factors of the antenatal period, influencing the development of congenital malformations of the urinary system. The results obtained must be taken into account at the stages of planning pregnancy in an outpatient setting.

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Polymorphism in folate cycle genes in patients with gout in the Russian population of Trans-Baikal Territory

Cited by 3 publications

References 17 publications

Clinical significance of 24-hour blood pressure monitoring in prediction of hypertension development in patients with gout

Clinical significance of 24-hour blood pressure monitoring in prediction of hypertension development in patients with gout

Allelic variants of folate metabolism genes among students in Arctic Russia

Assessment of antenatal risk factors for the formation of congenital defects of the development of the urinary system in children

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