Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease

Szalai, Csaba; Keszei, Márton; Duba, J.; Prohászka, Zoltán; Kozma, Gergely Tibor; Császár, Albert; Balogh, Sándor; Almássy, Zsuzsa; Füst, George; Czinner, A

doi:10.1016/j.atherosclerosis.2003.12.003

Cited by 109 publications

(86 citation statements)

References 24 publications

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“…The result of this study shown that, both the gene polymorphism (-1131T/C and -56C/G) is associated with increased risk of AMI. This finding agree with result of Szalai et al, 2004 andSoufi et al, 2012 who worked on above mentioned gene polymorphism and found the significant result with AMI patients. Szalai et al, 2004 investigated the role of this polymorphism in Hungarian CAD patients and found that after adjusted for age, gender, presence of diabetes, BMI, smoking, LDL-C, HDL-C and hypertension a significantly increased risk of developing CAD was found in patients carrying the APOA5 -1131C allele (p<0.001; OR=1.98 (1.14-3.48)), suggesting that this allele variant is an independent genetic risk factor for CAD.…”

Section: Discussionsupporting

confidence: 92%

“…This finding agree with result of Szalai et al, 2004 andSoufi et al, 2012 who worked on above mentioned gene polymorphism and found the significant result with AMI patients. Szalai et al, 2004 investigated the role of this polymorphism in Hungarian CAD patients and found that after adjusted for age, gender, presence of diabetes, BMI, smoking, LDL-C, HDL-C and hypertension a significantly increased risk of developing CAD was found in patients carrying the APOA5 -1131C allele (p<0.001; OR=1.98 (1.14-3.48)), suggesting that this allele variant is an independent genetic risk factor for CAD. Soufi et al, 2012 screened the APOA5 gene in subjects with CAD and conclude that, APOA5 p.S19W is a common variant, with very few additional APOA5 gene mutations; APOA5 p.S19W plays a major role in triglyceride metabolism; and APOA5 p.S19W is a CAD risk factor.…”

Section: Discussionsupporting

confidence: 92%

“…University, Lucknow, India. Email: research.physiology@gmail.com member of the APOA4/APOC3/APOA1 apolipoprotein cluster (Pennacchio et al, 2001, van der Vliet et al, 2001. The human APOA5 gene is located at chromosome 11q23, displays a few polymorphisms in the promoter region (e.g., -1131T>C, -3A>G, S19W, IVS3+476G>A, 1259T>C, andG185C), which are associated with high plasma triglyceride (TG) levels and TGrelated diseases such as atherosclerotic diseases (Kao et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Srivastava¹,

Singh²,

Verma³

et al. 2015

J App Pharm Sci

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The aim of this study was to examine the allele and genotype of APOA5 -1131T/C (rs662799) and APOA5-56C/G (rs3135506) gene in acute myocardial (AMI) case and control subjects. 304 case and 304 controls were enrolled in this study. DNA was extracted using salting out method followed by polymerase chain reaction amplification and restriction endonuclease digestion (using MseI for -1131T/C and Taq1 for -56C/G). Digested PCR products were identified using agarose gel electrophoresis and stained with ethidium bromide. There was a strong association between APOA5 -1131T/C (TC vs. TT, OR= 1.58 and CC vs. TT OR= 2.43) and APOA5 -56C/G (CG vs. CC, OR= 1.64 and GG vs. CC, OR= 2.44) polymorphisms with AMI. Out of the six potential risk factors for coronary artery disease, only smoking, diabetes and hypertension were found to be associated with APOA5 gene and increased the risk of AMI. Smoking was the most prominent risk factor for both the genes. Other risk factors like history of dyslipidemia, obesity and family history of coronary artery disease did not reveal any potential association with the candidate gene. Our data demonstrate that both the SNPs in the APOA5 gene (-1131T/C, and -56C/G) were strongly associated with AMI in north Indian population.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Srivastava¹,

Singh²,

Verma³

et al. 2015

J App Pharm Sci

View full text Add to dashboard Cite

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“…[19][20][21][22][23][24][25] The combined estimate of the standardized mean difference in plasma triglyceride level between the TT and CC genotypes was 0.58 (95% CI: 0.43-0.74) in a random effects model. In a meta-analysis of four studies on healthy European subjects with sample sizes greater than 300, [26][27][28][29] the corresponding estimate between TT and TC/CC genotypes was 0.33 (95% CI: 0.24-0.43) (Figure 2b). Most of these European studies [26][27][28] did not report the triglyceride level in subjects with homozygous CC genotype due to the low MAF.…”

Section: Association With Plasma Triglyceridesmentioning

confidence: 99%

“…In a meta-analysis of four studies on healthy European subjects with sample sizes greater than 300, [26][27][28][29] the corresponding estimate between TT and TC/CC genotypes was 0.33 (95% CI: 0.24-0.43) (Figure 2b). Most of these European studies [26][27][28] did not report the triglyceride level in subjects with homozygous CC genotype due to the low MAF.…”

Section: Association With Plasma Triglyceridesmentioning

confidence: 99%

A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

et al. 2010

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Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 (APOA5) gene have been associated with hypertriglyceridaemia. We investigated which SNPs in the APOA5 gene were associated with triglyceride levels in two independent Chinese populations. In all, 1375 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study were genotyped for five tagging SNPs chosen from HapMap. Replication was sought in 1996 subjects from the Guangzhou Biobank Cohort Study. Among the five SNPs, rs662799 (-1131T4C) was strongly related to log-transformed triglyceride levels among Hong Kong subjects (b¼0.192, P¼2.6Â10 À13 ). Plasma triglyceride level was 36.1% higher in CC compared to TT genotype. This association was confirmed in Guangzhou subjects (b¼0.159, P¼1.3Â10 À12 ), and was significantly irrespective of sex, age group, obesity, metabolic syndrome, hypertension, diabetes, smoking and alcohol drinking. The odds ratios and 95% confidence interval for plasma triglycerides Z1.7 mmol/l associated with TC and CC genotypes were, respectively, 1.81 (1.37-2.39) and 2.22 (1.44-3.43) in Hong Kong and 1.27 (1.05-1.54) and 1.97 (1.42-2.73) in Guangzhou. Haplotype analysis suggested the association was due to rs662799 only. The corroborative findings in two independent populations indicate that the APOA5-1131T4C polymorphism is an important and clinically relevant determinant of plasma triglyceride levels in the Chinese population.

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Nutrigenetics of the lipoprotein metabolism

García‐Rios

Pérez-Martínez

Delgado-Lista

et al. 2011

Molecular Nutrition Food Res

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It is well known that lipid metabolism is a cornerstone in the development of the commonest important chronic diseases worldwide, such as obesity, cardiovascular disease, or metabolic syndrome. In this regard, the area of lipid and lipoprotein metabolism is one of the areas in which the understanding of the development and progression of those metabolic disorders has been studied in greater depth. Thus, growing evidence has demonstrated that while universal recommendations might be appropriate for the general population, in this area there is great variability among individuals, related to a combination of environmental and genetic factors. Moreover, the interaction between genetic and dietary components has helped in understanding this variability. Therefore, with further study into the interaction between the most important genetic markers or single-nucleotide polymorphisms (SNPs) and diet, it may be possible to understand the variability in lipid metabolism, which could lead to an increase in the use of personalized nutrition as the best support to combat metabolic disorders. This review discusses some of the evidence in which candidate SNPs can affect the key players of lipid metabolism and how their phenotypic manifestations can be modified by dietary intake.

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Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease

Cited by 109 publications

References 24 publications

Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

Influence of APOA5 (rs662799 and rs3135506) gene polymorphism in acute myocardial infarction patients and its association with basic coronary artery disease risk factors

A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

Nutrigenetics of the lipoprotein metabolism

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