Polymorphism in the STAT6 gene encodes risk for nut allergy

Abstract

Nut allergy is an important and potentially life threatening food allergy with a prevalence of one in

An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation

“…29,30 No natural coding sequence variants of STAT6 have been described-and no data are available on the functional impact of its noncoding variants and how these might underlie the association with asthmatic 21 and atopic phenotypes, 22,31 and now helminth burden. It is plausible that their actions should be on mRNA or protein quantity, and hence impact on the degree of STAT6-mediated transcriptional activation of many genes encoding the effector mechanisms of IL-4 and Il-13 signalling in Th-2 cells and at mucosae.…”

Polymorphism of the Interleukin-4, Interleukin-13, and Signal Transducer and Activator of Transcription 6 Genes in Indonesian Children with Minimal Change Nephrotic Syndrome

“…Polymorphism of the STAT6 gene has been reported to be associated with nut allergy [35], mild atopic asthma [36], and MCNS [32]. To determine whether polymorphisms of the STAT6 gene are relevant to MCNS in an Indonesian population, we investigated the involvement of the 2964G/A variant of the STAT6 3S untranslated region and found no association between this genotypic or allelic variant and MCNS in our subjects.…”

Update on risk factors for food allergy

“…21 Recently, an IL10 gene polymorphism has been associated with FA in a Japanese population, 22 and an IL13 polymorphism has been identified in association with FA in another study. 23 These studies will need to be replicated in different populations.…”