Polymorphism of hydrocortisone

Structural, Thermodynamic, and Kinetic Aspectsof the Trimorphism of Hydrocortisone

“…Both compounds are isotypic and crystallize in space group P2 1 2 1 2 1 . In this context it must be mentioned that Petropavlov and coworkers report on investigations on a metastable form of hydrocortisone 17. However, the reported unit cell parameters are in agreement with those published for the methanol solvate of hydrocortisone 14, 15…”

Investigations on the Desolvation Reaction of Pseudopolymorphic Forms of Hydrocortisone

“…Afterward the residues formed in this procedure were investigated by X-ray powder diffraction. In these experiments one new solvate with N,N′-dimethylformamide (5) was found in addition to the 2-propanol (1), methanol (2), pyridin (3), and chloroform (4) solvate reported previously [32][33][34][35][36][37][38][39] (Table 2).…”

“…However, these desolvation experiments on the pyridine solvate 3) of hydrocortisone. [35][36][37][38] Hydrogen bonding is shown as dashed lines. were performed several months after we have started this project.…”

Crystal structure, solid-state NMR spectra, and oxygen reactivity of five crystal forms of prednisolone tert-butylacetate

“…Nature (London) 1987, 328, 596. (11) The crude transcription mixture was extracted with 1:1 phenol/ chloroform, followed by chloroform, after which the aqueous layer was loaded directly on the Mono Q HR5/5 anion exchange column (Pharmacia). The product RNA was readily separated from the NTP's by eluting with the gradient: 25-100% B in 18 min; A = 20 mM sodium phosphate/20% acetonitrile pH 6.0, B = A + 1 M KC1; flow rate = 1.0 mL/min.…”

“…-Colorado State University. 11 University of York.understanding of their pharmaceutical properties [10][11][13][14][15][16][17][18] Solid state NMR spectroscopy using the CP/MAS technique is quite useful for the study of solids19-26 and polymorphs.27-30 It…”