Polymorphism of Pro12Ala in the Peroxisome Proliferator-Activated Receptor γ2 Gene in Iranian Diabetic and Obese Subjects

Mirzaei, Hassan; Akrami, Seyed Mohammad; Golmohammadi, Taghi; Doosti, Mahmood; Heshmat, Ramin; Nakhjavani, Manouchehr; Amiri, Parvin

doi:10.1089/met.2008.0099

Cited by 29 publications

(26 citation statements)

References 44 publications

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“…Regarding the relationship between the PPARg2 gene Pro12Ala polymorphism and blood lipids, the conclusions were also controversial (Douglas et al, 2001;Hasstedt et al, 2001;Ereqat et al, 2009;Mirzaei et al, 2009). We found that Ala allele frequencies were significantly different between those with hypertension with elevated blood lipids (P = 0.040) and the control group.…”

Section: Discussionmentioning

confidence: 62%

Association of the PPARγ2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia

Gao¹,

Wang²,

Yun³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. In order to determine whether Pro12Ala polymorphism of the peroxisome proliferator-activated receptor g2 (PPARg2) gene contributes to susceptibility to primary hypertension and metabolic lipid disorders, 482 unrelated subjects from Inner Mongolia were studied, including 137 healthy normotensive (controls) and 345 hypertensive subjects. PCR-RFLP was used to determine the genotypes of Pro12Ala variants of the PPARg2 gene, and direct sequencing was used to check the results. The frequency of the Ala allele was lower in patients with hypertension (1.3%) than in controls (3.6%). The incidence of the Ala allele was significantly lower in patients with hypertension (P = 0.018) 1313©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 9 (3): 1312-1320 (2010) PPARg2 and primary hypertension in Han Chinese and in those with elevated blood lipids (P = 0.040), compared to the control group. Total plasma cholesterol, triglycerides and high-density lipoprotein cholesterol were significantly higher (P < 0.05), and lowdensity lipoprotein cholesterol was significantly lower (P < 0.05) in primary hypertension patients than in the control group. We conclude that the Ala allele is involved in genetic susceptibility to hypertension and metabolic lipid disorders in the Han population of Inner Mongolia.

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Section: Discussionmentioning

confidence: 62%

Association of the PPARγ2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia

Gao¹,

Wang²,

Yun³

et al. 2010

Genet. Mol. Res.

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“…Nine cohort studies [12,25,26,27,28,29,30,31,32], 7 population case-control studies [33,34,35,36,37,38,39], 31 cross-sectional studies [5,7,10,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67], and 9 interventional studies [8,68,69,70,71,72,73,74,75] were included in the meta-analysis of the association between PPARγ Pro12Ala polymorphism and obesity. The characteristics and results of the studies are summarized in table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics and results of the studies are summarized in table 1. Seven population case-control studies [33,34,35,36,37,38,39], and 1 cross-sectional study [10] provided their data in 2 datasets. Each dataset was treated as a separate comparison in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Each dataset was treated as a separate comparison in the meta-analysis. Forty studies were on Caucasians [5,8,10,12,25,26,27,28,29,32,33,34,35,36,37,38,39,41,42,43,45,46,47,48,52,53,54,57,60,61,62,63,64,65,66,67,68,69,70], 10 studies were on Asian [31,40,49,50,55,56,58,59,71,72] and 6 studies were on mixed populations [7,30,37,73,74,75]. Between 56 studies, 19 studies provided data on male [10,12,29,33,35,37,40,42,43,47,50,57,60,61,62,65,66,69,71] and 22 studies on female members [10,12,29,32,37,41,42,50,53,54,55,59,60,61,62,64,66,…”

Section: Resultsmentioning

confidence: 99%

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Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis

et al. 2015

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Background: The aim of this systematic review was to evaluate the relationship between obesity and peroxisome proliferator-activated receptor-gamma (PPARγ) Pro12Ala polymorphism in healthy adults. Summary: Weighted mean differences (WMDs) of body mass index (BMI) were calculated for different inheritance models and subgroups. Fifty-six studies were eligible for inclusion in the meta-analysis. The result shows that the Ala allele of this polymorphism was associated with increased WMD in mean BMI (WMD = 0.29, 95% CI 0.10-0.48, p = 0.003). The Ala carriers were associated with increased WMD in mean BMI values in both genders and in the Caucasian subgroup. The associations were seen among people with higher levels of BMI (BMI ≥35). Message: The Ala allele of the PPARγ Pro12Ala polymorphism in healthy adults was associated with increased BMI under a dominant model of inheritance.

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“…Although early findings were inconsistent, replication studies and meta-analyses confirmed modest but significant increase in type 2 diabetes risk associated with the Pro allele (12). However, the relationship of Pro12Ala variant with obesity, MetS and related traits is less defined (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Similarly, conflicting results were obtained regarding the association between met abolic phenotypes and another frequent variant, a silent mutation in exon 6 of the PPARG gene, 1431C>T (c.1431C>T, rs3856806) (13, 14, 16-18, 23, 24).…”

Section: Introductionmentioning

confidence: 99%

Effects of the PPARG Gene Polymorphisms on Markers of Obesity and the Metabolic Syndrome in Bosnian Subjects

Dujić¹,

Bego²,

Mlinar³

et al. 2014

Journal of Medical Biochemistry

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SummaryBackground: Peroxisome proliferator-activated receptor gamma (PPARg) is a key transcription factor in adipogenesis, and also regulates a number of genes associated with lipid storage and insulin sensitivity. Single nucleotide polymorphisms (SNPs) in the PPARG gene have been associated with obesity and diabetes. In this study, we explored the relationship of three PPARG gene variants with the metabolic syndrome (MetS) and related traits in a population from Bosnia and Herzegovina. Methods: Anthropometric and biochemical parameters were measured in 43 patients with MetS and 43 healthy controls. Subjects were genotyped for Pro12Ala (rs1801282) and 1431C>T (rs3856806) SNPs by classic PCR-restriction fragment length polymorphism analysis, and for -681C>G (rs10865710) variant by real-time PCR. Results: The genotype distributions for the three polymorphisms were not significantly different between MetS patients and controls. The Pro12Ala and 1431C>T variants were associated with lower body mass index in the control subjects (p=0.012 and p=0.049, respectively). In this group, the carriers of Pro12Ala had also lower waist circumference compared to the wild-type homozygotes (p=0.045).

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Polymorphism of Pro12Ala in the Peroxisome Proliferator-Activated Receptor γ2 Gene in Iranian Diabetic and Obese Subjects

Abstract: Our results showed that the Pro12Ala polymorphism in the PPARgamma2 gene is associated with obesity in Iranian subjects and the presence of the Ala allele could predict higher BMI.

Cited by 29 publications

References 44 publications

Association of the PPARγ2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia

Association of the PPARγ2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia

Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis

Effects of the PPARG Gene Polymorphisms on Markers of Obesity and the Metabolic Syndrome in Bosnian Subjects

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