Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation

Bouchard-Mercier, Annie; Rudkowska, Iwona; Lemieux, Simone; Couture, Patrick; Vohl, Marie‐Claude

doi:10.1194/jlr.m041590

Cited by 21 publications

(18 citation statements)

References 43 publications

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“…peroxisome proliferator-activated receptors family (PPAR), ATP citrate lyase (ACYL) and acetyl-CoA carboxylase (ACACA)) and transport (e.g. apo E (apo E)) have been identified as modulators of TAG response to LCn3-PUFA supplementation (12,(28)(29)(30) . To our knowledge, only one randomised controlled trial has assessed how the apo E genotype modulates the TAG response to DHA and EPA-rich oils (31) .…”

Section: Discussionmentioning

confidence: 99%

Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study

et al. 2019

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Studies have shown that the reduction in serum TAG concentrations with long-chain n-3 fatty acid supplementation is highly variable among individuals. The objectives of the present study were to compare the proportions of individuals whose TAG concentrations lowered after high-dose DHA and EPA, and to identify the predictors of response to both modalities. In a double-blind, controlled, crossover study, 154 men and women were randomised to three supplemented phases of 10 weeks each: (1) 2·7 g/d of DHA, (2) 2·7 g/d of EPA and (3) 3 g/d of maize oil, separated by 9-week washouts. As secondary analyses, the mean intra-individual variation in TAG was calculated using the standard deviation from the mean of four off-treatment samples. The response remained within the intra-individual variation (±0·25 mmol/l) in 47 and 57 % of participants after DHA and EPA, respectively. Although there was a greater proportion of participants with a reduction >0·25 mmol/l after DHA than after EPA (45 υ. 32 %; P < 0·001), the mean TAG reduction was comparable between groups (–0·59 (sem 0·04) υ. –0·57 (sem 0·05) mmol/l). Participants with a reduction >0·25 mmol/l after both DHA and EPA had higher non-HDL-cholesterol, TAG and insulin concentrations compared with other responders at baseline (all P < 0·05). In conclusion, supplementation with 2·7 g/d DHA or EPA had no meaningful effect on TAG concentrations in a large proportion of individuals with normal mean TAG concentrations at baseline. Although DHA lowered TAG in a greater proportion of individuals compared with EPA, the magnitude of TAG lowering among them was similar.

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Section: Discussionmentioning

confidence: 99%

Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study

et al. 2019

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“…Methods related to this study cohort have been previously described [ 31 ]. Briefly, a total of 254 unrelated participants from the greater Quebec City metropolitan area were recruited to participate in this clinical trial between September 2009 and December 2011 through advertisements in local newspapers as well as by electronic messages sent to university students/employees.…”

Section: Methodsmentioning

confidence: 99%

“…The study design and diets have been described previously [ 31 ]. Briefly, participants followed a run-in period of 2 weeks.…”

Section: Methodsmentioning

confidence: 99%

“…As described previously [ 31 ], SNPs were selected with the International HapMap Project SNP database (HapMap Data Rel 28 Phase II + III, August 10, on National Center for Biotechnology Information (NCBI) B36 assembly, dbSNP b126). Tag SNPs (tSNPs) were determined with the tagger procedure in HaploView software version 4.2 with minor allele frequency (MAF) of >0.05 and pairwise tagging r 2 ≥ 0.80.…”

Section: Methodsmentioning

confidence: 99%

“…As described previously [ 44 ], FA composition was measured in erythrocyte membranes by gas chromatographic analysis in a subset of 31 participants. Methods to extract plasma phospholipids have been described elsewhere [ 31 ]. FA composition from plasma phospholipids were measured on the total cohort of 210 participants.…”

Section: Methodsmentioning

confidence: 99%

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SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation

Bouchard-Mercier

Rudkowska²,

Lemieux

et al. 2014

Lipids Health Dis

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BackgroundAn important inter-individual variability in the response of insulin sensitivity following a fish oil supplementation has been observed. The objective was to examine the associations between single nucleotide polymorphisms (SNPs) within sterol regulatory element binding transcription factor 1 (SREBF1) gene and the response of insulin sensitivity to a fish oil supplementation.MethodsParticipants (n = 210) were recruited in the greater Quebec City area and followed a 6-week fish oil supplementation protocol (5 g/day: 1.9-2.2 g EPA; 1.1 g DHA). Insulin sensitivity was assessed by the quantitative insulin sensitivity check index (QUICKI). Three tag SNPs (tSNPs) within SREBF1 gene were genotyped according to TAQMAN methodology.ResultsThree tSNPs (rs12953299, rs4925118 and rs4925115) covered 100% of the known genetic variability within SREBF1 gene. None of the three tSNPs was associated with either baseline fasting insulin concentrations (rs12953299, rs4925118 and rs4925115) (p = 0.29, p = 0.20 and p = 0.70, respectively) or QUICKI (p = 0.20, p = 0.18 and p = 0.76, respectively). The three tSNPs (rs12953299, rs4925118 and rs4925115) were associated with differences in the response of plasma insulin levels (p = 0.01, p = 0.005 and p = 0.004, respectively) and rs12953299 as well as rs4925115 were associated with the insulin sensitivity response (p = 0.009 and p = 0.01, respectively) to the fish oil supplementation, independently of the effects of age, sex and BMI.ConclusionsThe genetic variability within SREBF1 gene has an impact on the insulin sensitivity in response to a fish oil supplementation.Trial registrationclinicaltrials.gov: NCT01343342.

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An interaction effect between glucokinase gene variation and carbohydrate intakes modulates the plasma triglyceride response to a fish oil supplementation

Bouchard-Mercier

Rudkowska²,

Lemieux

et al. 2014

Genes Nutr

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A large inter-individual variability in the plasma triglyceride (TG) response to fish oil consumption has been observed. The objective was to investigate the gene-diet interaction effects between single-nucleotide polymorphisms (SNPs) within glucokinase (GCK) gene and dietary carbohydrate intakes (CHO) on the plasma TG response to a fish oil supplementation. Two hundred and eight participants were recruited in the greater Quebec City area. The participants completed a 6-week fish oil supplementation (5 g fish oil/day: 1.9-2.2 g EPA and 1.1 g DHA).Thirteen SNPs within GCK gene were genotyped using TAQMAN methodology. A gene-diet interaction effect on the plasma TG response was observed with rs741038 and CHO adjusted for age, sex and BMI (p = 0.008). In order to compare the plasma TG response between genotypes according to CHO, participants were divided according to median CHO. Homozygotes of the minor C allele of rs741038 with high CHO [48.59 % had a greater decrease in their plasma TG concentrations following the intake of fish oil (p \ 0.05) than C/C homozygotes with low CHO and also than the other genotypes either with high or low CHO. The plasma TG response to a fish oil supplementation may be modulated by gene-diet interaction effects involving GCK gene and CHO.

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Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation

Cited by 21 publications

References 43 publications

Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study

Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study

SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation

An interaction effect between glucokinase gene variation and carbohydrate intakes modulates the plasma triglyceride response to a fish oil supplementation

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