Polymorphisms identification and associations of KLF7 gene with cattle growth traits

Ma, Li-na; Qu, Yujiao; Huai, Y. T.; Li, Z.J.; Wang, J.; Lan, Xianyong; Zhang, C.L.; Wang, J.Q.; Chen, H.

doi:10.1016/j.livsci.2010.04.014

Cited by 18 publications

(11 citation statements)

References 18 publications

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“…The frequencies of G allele were 0.54-0.55 and frequencies of A allele were 0.46-0.45, and the PIC was 0.37 (Table 2). According to the classification of PIC (low polymorphism if PIC value <0.25, moderate polymorphism if 0.25 <PIC value <0.50, and high polymorphism if PIC >0.50) (Ma et al 2011), the three goat breeds at P2 locus had moderate genetic diversity. The P2 locus were in Hardy-Weinberg equilibrium in SN and GZ breeds (P>0.05), which showed the genotypic frequencies has not been affected by selection, mutation or migration in both goat breeds.…”

Section: Resultsmentioning

confidence: 99%

Polymorphism identification in the goat THRSP gene and association analysis with growth traits

Zhao

Bai

et al. 2012

Arch. Anim. Breed.

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In this study, we reported the analysis of THRSP gene polymorphisms in 610 goats of three breeds: Xinong Saanen (SN), Guanzhong (GZ) and Boer (BG). We identified new allelic variant: P2-G39294A (GenBank acc. no. JN618075) in the three goat breeds. At P2 locus, GG, GA and AA genotypes were found in the three goat breeds. The frequencies of G allele were 0.54-0.55 and frequencies of A allele were 0.46-0.45, and the PIC was 0.37. The SNP locus was in Hardy-Weinberg disequilibrium in Boer goat breed (P<0.05). Association of polymorphisms with growth traits was done at P2 locus in Boer goat breed. The result showed that AA genotype had remarkable growth traits at P2 locus (P<0.05). Therefore, these results suggest that THRSP gene is a strong candidate gene that affects growth traits in goat.

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Section: Resultsmentioning

confidence: 99%

Polymorphism identification in the goat THRSP gene and association analysis with growth traits

Zhao

Bai

et al. 2012

Arch. Anim. Breed.

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“…The H E , N E , and PIC values of G21234C, C22424T, and C22481T SNPs were 0.4667, 1.8752, and 0.3578, 0.2982, 1.4250 and 0.2538, and 0.1606, 1.1941, and 0.1477, respectively. According to a standard (high, medium, and low polymorphism if PIC > 0.5, 0.25 < PIC < 0.5, or PIC < 0.25, respectively; Ma et al, 2011), both G21234C and C22424T loci had a medium level of polymorphism, while C22481T locus had a low level of polymorphism. Table 4.…”

Section: Genetic Polymorphism Of the Qinchuan Cattle Smo Gene And χ 2mentioning

confidence: 99%

Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle

Zhang¹,

Li²,

Fu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Beef cattle breeding programs focus on improving important economic traits, including growth rates, and meat quantity and quality. Molecular marker-assisted selection based on genetic variation represents a potential method for breeding genetically improved livestock with better economic traits. Smoothened (SMO) protein is a signal transducer that contributes to the regulation of both osteogenesis and adipogenesis through the hedgehog pathway. In this study, we detected polymorphisms in the bovine SMO gene of Qinchuan cattle, and we analyzed their associations with body measurement traits (BMTs) and meat quality traits (MQTs). Using DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism, 3 novel single nucleotide polymorphisms were identified in the SMO gene of 562 cattle: 1 G > C mutation on exon 9 (G21234C) and 2 C > T mutations on exon 11 (C22424T and C22481T). Association analysis showed that polymorphisms on both the G21234C and C22424T loci significantly affected certain BMTs and MQTs (P < 0.05 or P < 0.01), whereas those on the C22481T locus did not (P > 0.05). Therefore, the SMO gene could be used as a candidate gene to alter BMTs and MQTs in Qinchuan cattle or for marker-assisted selection to breed cattle with superior BMTs and MQTs.

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“…Previous reports showed that iPSC-related Klf4 affected adipogenesis through interacting with other genes. Equally, Klf7 also affected bovine growth traits and the quality of milk (Ma et al, 2011). The examples above were evidence to suppose that iPSC-related Nanog may influence the phenotypes.…”

Section: Discussionmentioning

confidence: 90%

“…Among them, the iPSC-related transcription factor Klf4 is necessary for adipose differentiation and development (Cervantes-Camacho et al, 2015). Similarly, Klf7 regulated energy metabolism and affected bovine growth (Ma et al, 2011). Thus, another iPSC-related transcription factor Nanog was inferred to affect growth traits in cattle.…”

Section: Introductionmentioning

confidence: 99%

Exploration of the exonic variations of the iPSC-related Nanog gene and their effects on phenotypic traits in cattle

Zhang¹,

Pan²,

Lin³

et al. 2016

Arch. Anim. Breed.

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Abstract. Nanog is an important pluripotent transcription regulator transforming somatic cells to induced pluripotent stem cells (iPSCs), and its overexpression leads to a high expression of the growth and differentiation factor 3 (GDF3), which affects animal growth traits. Therefore, the aim of this study was to explore the genetic variations within the Nanog gene and their effects on phenotypic traits in cattle. Six novel exonic single nucleotide polymorphisms (SNPs) were found in six cattle breeds. Seven haplotypes were analyzed: TCAACC (0.260), TCAATA (0.039), TCATCC (0.019), TCGACC (0.506), TCGATA (0.137), TCGTCC (0.036), and CT-GATA (0.003). There were strong linkage disequilibriums of SNP1 and SNP2 in Jiaxian cattle as well as of SNP5 and SNP6 in both Jiaxian cattle and Nanyang cattle. Moreover, SNP3, SNP4, and SNP5 were associated with phenotypes. The individuals with GG genotype at the SNP3 locus or AA genotype at the SNP4 locus showed better body slanting length and chest circumference or body height and hucklebone width in Nanyang cattle. The superiority of the SNP5-C allele regarding body height and cannon circumference was observed in Jiaxian cattle. The combination of SNP3 and SNP4 (GG-AA) had positive effects on body height, body slanting length, and chest circumference. These findings may indicate that Nanog, as a regulator of bovine growth traits, could be a candidate gene for marker-assisted selection (MAS) in breeding and genetics in cattle.

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Polymorphisms identification and associations of KLF7 gene with cattle growth traits

Cited by 18 publications

References 18 publications

Polymorphism identification in the goat <i>THRSP</i> gene and association analysis with growth traits

Polymorphism identification in the goat <i>THRSP</i> gene and association analysis with growth traits

Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle

Exploration of the exonic variations of the iPSC-related <i>Nanog</i> gene and their effects on phenotypic traits in cattle

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Polymorphisms identification and associations of KLF7 gene with cattle growth traits

Cited by 18 publications

References 18 publications

Polymorphism identification in the goat &lt;i&gt;THRSP&lt;/i&gt; gene and association analysis with growth traits

Polymorphism identification in the goat &lt;i&gt;THRSP&lt;/i&gt; gene and association analysis with growth traits

Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle

Exploration of the exonic variations of the iPSC-related &lt;i&gt;Nanog&lt;/i&gt; gene and their effects on phenotypic traits in cattle

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Product

Resources

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Polymorphism identification in the goat <i>THRSP</i> gene and association analysis with growth traits

Polymorphism identification in the goat <i>THRSP</i> gene and association analysis with growth traits

Exploration of the exonic variations of the iPSC-related <i>Nanog</i> gene and their effects on phenotypic traits in cattle