Polymorphisms in Candidate Asthma Genes

Nanavaty, Uday B.; Goldstein, Adam; Levine, Stewart J.

doi:10.1097/00000441-200101000-00003

Cited by 26 publications

(11 citation statements)

References 31 publications

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“…Genetic factors, especially the gene associated with an important lung antioxidant, glutathione, may determine International Journal of Environmental Health Research 359 children's susceptibility to damage from the toxic effects of passive smoking (Weiss 1999;Nanavaty et al 2001). Although some mentioned theories could explain the possible mechanistic aspects by which passive smoking adverse physical condition in children, further investigations are needed for better understanding these mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Influence of passive smoking on functional abilities in children

Pavić

Pavić²,

Palčić

et al. 2012

International Journal of Environmental Health Research

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Passive smoking has been found to be associated with a large number of disorders of passive smokers. It seems that the children are the most susceptible population for harmful effects of passive smoke exposure. The aim of this study was to evaluate the effect of passive smoking on children's functional abilities. The target population was 199 children who were 13-15 years old at the time of the study. For the assessment of motor skills 6-min run test was used. Children exposed to passive smoking by their mothers had statistically significant lower functional abilities (r =-0.7029; 95% CI -0.7707 to -0.6194; p < 0.0001). We also found statistically significant difference if the both parents are smokers (r =-0.3343; 95% CI -0.4595 to -0.1961; p < 0.0001). The results of our study did not show statistically significant difference if the children are exposed to cigarette smoke by their fathers (r = 0.03139; 95% CI -0.1171 to 0.1785; p = 0.6792). Public health preventive actions should go toward minimizing the exposure of children to passive smoking by counseling the smoking parents that quitting smoking provides enormous health benefits not only to them but also to their children.

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Section: Discussionmentioning

confidence: 99%

Influence of passive smoking on functional abilities in children

Pavić

Pavić²,

Palčić

et al. 2012

International Journal of Environmental Health Research

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“…Neither IL-4-deficient nor IL-13-deficient mice produce wild-type levels of IgE following immunization with OVA (19 -21) or treatment with anti-IgD (22), suggesting that one cytokine does not fully compensate for lack of the other. In contrast, infection with the murine AIDS (MAIDS) 3 virus generates a full IgE response in IL-4-deficient mice (22), indicating that IL-13 preferentially drives IgE production during this infection. Even more intriguing are observations that suggest IgE can be made in the absence of both IL-4 and IL-13, or in the absence of their shared signaling elements.…”

Section: Ige Generation and Mast Cell Effector Function In Micementioning

confidence: 99%

“…This relationship is underscored by observations that genetic polymorphisms predisposing humans to high serum IgE levels are associated with the development of asthma (1)(2)(3). Several of these polymorphisms affect genes encoding IL-4, IL-13, or their receptor components, attesting to the critical importance of these cytokines in regulating IgE levels in vivo (4 -13).…”

Section: Ige Generation and Mast Cell Effector Function In Micementioning

confidence: 99%

IgE Generation and Mast Cell Effector Function in Mice Deficient in IL-4 and IL-13

Fish¹,

Donaldson²,

Goldman³

et al. 2005

The Journal of Immunology

104

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IL-4 and IL-13 are potent cytokines that drive production of IgE, which is critical to the development of atopic disease. In this study, we directly compared IgE generation and IgE-dependent mast cell effector function in mouse strains lacking IL-4, IL-13, IL-4 + IL-13, or their common receptor component, IL-4Rα. Although serum IgE was undetectable under resting conditions in most animals deficient in one or both cytokines, peritoneal mast cells from mice lacking IL-4 or IL-13 had only partial reductions in surface IgE level. In contrast, peritoneal mast cells from IL-4/13−/− and IL-4Rα−/− animals were severely deficient in surface IgE, and showed no detectable degranulation following treatment with anti-IgE in vitro. Surprisingly, however, intradermal challenge with high concentrations of anti-IgE Ab induced an ear-swelling response in these strains, implying some capacity for IgE-mediated effector function in tissue mast cells. Furthermore, upon specific immunization with OVA, both IL-4/IL-13−/− and IL-4Rα−/− mice produced detectable levels of serum IgE and Ag-specific IgG1, and generated strong ear-swelling responses to intradermal administration of anti-IgE. These findings suggest that a mechanism for IgE production exists in vivo that is independent of IL-4 or IL-13.

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“…On similar lines, genetic factors may also determine children's susceptibility to the harmful effects of ETS [75,112].…”

Section: Ets Exposure and Genetic Susceptibilitymentioning

confidence: 99%

Environmental tobacco smoke (ETS) and respiratory health in children

Cheraghi

Salvi²

2009

Eur J Pediatr

165

119

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Environmental tobacco smoke (ETS) is a major risk factor for poor lung health in children. Although parental smoking is the commonest source of ETS exposure to children, they are also exposed to ETS in schools, restaurants, public places and public transport vehicles. Apart from containing thousands of chemicals, the particle size in the ETS is much smaller than the main stream smoke, and therefore has a greater penetrability in the airways of children. Exposure to ETS has been shown to be associated with increased prevalence of upper respiratory tract infections, wheeze, asthma and lower respiratory tract infections. Even developing fetuses are exposed to ETS via the umbilical cord blood if the mother is exposed to tobacco smoke. The placenta also does not offer any barrier to the penetration of ETS into the fetus. The immune system in these babies is more deviated toward the allergic and asthmatic inflammatory phenotype and therefore makes them more prone to develop asthma later in life. An increased awareness of the harmful effects of ETS on children's health is warranted.

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Polymorphisms in Candidate Asthma Genes

Cited by 26 publications

References 31 publications

Influence of passive smoking on functional abilities in children

Influence of passive smoking on functional abilities in children

IgE Generation and Mast Cell Effector Function in Mice Deficient in IL-4 and IL-13

Environmental tobacco smoke (ETS) and respiratory health in children

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