Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women

Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women

“…The CYP19A1 gene encodes aromatase, which is a cytochrome P450 enzyme that converts androgens to oestrogens (11) . A previous study of the same population of our investigation reported that both serum E1 and E2 concentrations were higher in those with the C allele of rs4441215 or the T allele of rs936306 of the CYP19A1 gene than postmenopausal women without these alleles (12) . To our knowledge, this is the first study to explore interactions between intakes of nutrients or foods and these polymorphisms.…”

“…To examine associations of lifestyle, genetic and medical factors by using a subset of this population, 500–600 consecutive subjects were selected in ten study areas and 4519 participants (2124 men and 2395 women) were eventually included in the cross-sectional study ( 18 ) . Of these subjects, 799 naturally menopaused women aged 47–69 years were selected in nine study areas for the present study ( 12 ) ; one study area was dropped because serum samples were not available for the current study. Natural menopause was defined as no menstruation for at least 12 consecutive months, except for menopause caused by surgeries of the uterus or ovaries or other reasons.…”

“…In addition to such dietary factors, genetic factors have been suggested to play an important role in the risk of hormone-dependent cancer through the biosynthesis of oestrogens (5,11) . Polymorphisms in the CYP19A1 gene that encodes aromatase, an enzyme that converts androgens to oestrogens, were shown to be associated with serum sex hormone levels in Japanese people (11)(12)(13) . The rs605059 polymorphism in the HSD17B1 gene that encodes 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), which catalyses the synthesis of E2 from oestrone (E1), has been investigated regarding its association with multiethnic breast cancer risk (14,15) .…”

Polymorphisms in Estrogen Synthesis Genes and Symptom Clusters During the Menopausal Transition and Early Postmenopause: Observations From the Seattle Midlife Women’s Health Study

“…Both the cytochrome P 450 (CYP 19) and 17 beta hydroxysteroid dehydrogenase (17HSDB) enzymes play important roles in estrogen synthesis (Gruber, Uschugguel, Schneeberger, & Huber, 2002; see Figure 1). CYP 19 (aromatase) mediates the conversion of androgens (testosterone and androstenedione) to estrogens (estradiol and estrone, respectively), processes that occur in both gonadal and extragonadal tissues (Hosono et al, 2015). The CYP 19 gene, located on 15q21.1, encodes aromatase, and the rs10046 single-nucleotide polymorphism (SNP) has been related to circulating levels of estradiol (Dumas & Diorio, 2011).…”

“…The CYP 19 gene, located on 15q21.1, encodes aromatase, and the rs10046 single-nucleotide polymorphism (SNP) has been related to circulating levels of estradiol (Dumas & Diorio, 2011). The 17HSDB1 catalyzes the conversion of estrone to estradiol, and 17HSDB2 catalyzes the conversion of estradiol to estrone (Hosono et al, 2015). The 17HSD gene is located on chromosome 17q11-q21, and 17HSDB1 SNPs have been related to age at menopause (Mitchell et al, 2008) and to estradiol trajectories around the time of menopause (Sowers et al, 2011).…”