Polymorphisms in DNA Repair Genes and Risk of Glioma and Meningioma

Association between the XRCC1 Arg194Trp Polymorphism and Glioma Risk: an Updated Meta-analysis

“…Furthermore, three recent meta-analyses by Luo et al (2013), Pan et al (2013) and Xu et al (2013) were evaluated the association between Arg194Trp polymorphism and glioma risk, which was basically in consist with our meta-analysis results that Arg194Trp polymorphism may contribute to the susceptibility of glioma, particularly in Asians, but not in Caucasians. It is notable that given the specific multiplicity of possible comparisons and the inescapable adaptation of choosing, associations may have been detected by chance alone.…”

“…Among them, the XRCC1 Arg194Trp variant located in the proliferating cell nuclear antigen (PCNA) binding region, which suggests that this mutation may be result in gliomagenesis. However, these studies have failed to yield a consistent conclusion (Kiuru et al, 2008;Liu et al, 2009;McKean-Cowdin et al, 2009;Rajaraman et al, 2010;Custodio et al, 2011;Hu et al, 2011;Zhou et al, 2011;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013;Wang et al, 2012;Xu et al, 2013).…”

Association of XRCC3 Thr241Met Polymorphisms and Gliomas Risk: Evidence from a Meta-analysis

“…Of these articles, two was excluded because on (Goode et al, 2002) is a review and the other is a repeated article (Zhou et al, 2009). At last, a total of nine studies were included in this meta-analysis (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Zhou et al, 2009;Rajaraman et al, 2010;Custodio et al, 2012;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013), all of these publications were written in English. The study characteristics of the included in the meta-analysis were presented in Table 1.…”

The XRCC3 Thr241Met Polymorphism Influences Glioma Risk - A Meta-analysis

“…According to the inclusion and exclusion criteria, a total of nine publications with 3,752 Cases and 4,849 Controls were included in this meta-analysis (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Zhou et al, 2009;Rajaraman et al, 2010;Custódio et al, 2012;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013). Among the nine studies, four studies (Zhou et al, 2009;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013) were performed in Asian populations and four (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010) were conducted in Caucasian populations.…”

“…Among the nine studies, four studies (Zhou et al, 2009;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013) were performed in Asian populations and four (Wang et al, 2004;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010) were conducted in Caucasian populations. Five of the studies (Wang et al, 2004;Zhou et al, 2009;Rajaraman et al, 2010;Liu et al, 2012;Luo et al, 2013) were hospital-based and four (Kiuru et al, 2008;Liu et al, 2009;Custódio et al, 2012;Pan et al, 2013) were population-based. The genotype distributions in the controls were conformed to the HWE in all studies.…”