Polymorphisms in ERCC1 and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population

Association of ERCC1 polymorphisms and susceptibility to nasopharyngeal carcinoma

“…In the current study, the frequency of 8092 C allele among the healthy Chinese population was 69.4%, which was comparable to that in other healthy Chinese [9], but this frequency was lower than those of American, Norwegians (74.8%, 75.5%, and 73.4%, respectively) [11,16,17]. The allele frequency of ERCC1 19007 T among the controls was 63.0%, which was similar to those observed in healthy American and European (60.9%, 59.8%, respectively) [16,18], but it differs from values previously reported in Norwegians and Chinese population (46.2% and 20.3% respectively) [11,19].…”

“…Studies showed that the two common polymorphisms of ERCC1, 19007 C > T (rs11615) and 8092C > A (rs3212986) may affect ERCC1 mRNA levels [7,8]. The 8092C > A polymorphism is significantly associated with the risk of Oligoastrocytoma [8], acute lymphoblastic leukemia [9], and squamous cell carcinoma of head and neck (SCCHN) [10]. The 19007 C > T polymorphism is significantly associated with the non-small cell lung cancer (NSCLC) risk [11].…”

DNA Repair Deficiency Associated with Hematological Neoplasms

“…XPD Asp312Asn and Lys751Gln polymorphisms, which have been previously associated with AML, have not been found to be correlated with ALL risk (Batar et al 2009, da Silva Silveira et al 2009). On the contrary, CC genotype of ERCC18092C>A polymorphism has been suggested to increase susceptibility to ALL in Chinese children (Wang et al 2006). In the same study, ERCC1 19007G>A was not found to be associated with ALL (Wang et al 2006).…”

“…On the contrary, CC genotype of ERCC18092C>A polymorphism has been suggested to increase susceptibility to ALL in Chinese children (Wang et al 2006). In the same study, ERCC1 19007G>A was not found to be associated with ALL (Wang et al 2006). Regarding Mismatch Repair (MMR) mechanism, most of the existing studies have failed to show an association between MMR deficiency and ALL development (Molenaar et al 1998, Takeuchi et al 1997, although preclinical studies have demonstrated MSI in ALL cell lines (Gu et al 2002, Hangaishi et al 1997).…”

Imunolocalização, metilação e polimorfismo do gene ERCC1 em carcinoma espinocelular de cabeça e pescoço: correlação com parâmetros clínicos, controle locorregional e sobrevida

“…The ERCC1 (G19007A) polymorphisms were determined by PCR-RFLP (restriction fragment lengh polimorphysm) 9 . PCR was performed in a volume of 25 μL …”