Polymorphisms in IL‐1A are associated with endometrial cancer susceptibility among Chinese Han population: A case–control study

Liu, Ying; Sun, Yao; Wu, Jia‐Min; Xiong, Zichao; Du, Shuli; Niu, Fanglin; Jin, Tianbo; Guo, Ling

doi:10.1111/iji.12463

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Until now, very few articles have been published on the association between serum levels and gene polymorphisms of IL‐27 and the risk of endometriosis. However, in ovarian or endometrial cancers that share similar molecular pathogenesis with endometriosis (Kori et al., 2016; Liu et al., 2020), some studies indicated that IL‐27 protein or IL27‐p28 transcript declined (Zhang et al., 2014; Zhao et al., 2020). Besides, the G allele of IL‐27 rs153109 was higher in patients with ovarian cancer or endometrial cancer (Liu et al., 2016; Zhang et al., 2014).…”

Section: Discussionmentioning

confidence: 99%

Association between gene polymorphisms of IL‐12, IL‐12 receptor and IL‐27 and organ involvement in Iranian endometriosis patients

Zare

Hesampour

Poordast

et al. 2022

Int J Immunogenetics

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Endometriosis is an inflammatory disease characterized by the presence of ectopic endometrial tissue, immune cell dysfunction and abnormal cytokine secretion. In addition to immunological factors, genetic variations that influence endometriosis severity and cytokine expression levels play important roles in the pathogenesis of this disease. Interleukin-12 (IL-12), specifically its p40 subunit encoded by IL-12B gene and the interleukin-12 receptor β1 (IL-12Rβ2) chain of its receptor, as well as interleukin-27 (IL-27) are important in the establishment of endometriosis. So, in this study, we measured IL-12 and IL-27 serum levels and investigated the possible links between IL-12B rs3212227, IL-12Rβ2 rs3790565 and IL-27 rs153109 polymorphisms and the risk of developing endometriosis in a group of Iranian women. In this case-control study, 162 endometriosis patients and 151 healthy women were included and tested for the aforementioned polymorphisms using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The enzyme-linked immunosorbent assay (ELISA) method was also used to measure IL-12 and IL-27 serum levels. Although there was no statistically significant association between the genotypes and alleles of the studied polymorphisms and the development of endometriosis in general, the AA genotype of IL-12B rs3212227 showed a significant association with uterine endometriosis when compared to AC+CC genotypes (p = .04, CI = 0.270-0.988, OR = 0.517). Indeed, the AA genotype of the IL-12B rs3212227 single nucleotide polymorphism (SNP) may be linked with a lower risk of developing uterine endometriosis.There was no significant difference in IL-27 levels between the two studied groups (p = .49), and IL-12 levels were undetectable in both groups. In conclusion, the AA genotype of IL-12B rs3212227 might be associated with a decreased risk of uterine involvement in endometriosis patients.

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Section: Discussionmentioning

confidence: 99%

Association between gene polymorphisms of IL‐12, IL‐12 receptor and IL‐27 and organ involvement in Iranian endometriosis patients

Zare

Hesampour

Poordast

et al. 2022

Int J Immunogenetics

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“…The single nucleotide polymorphism (SNP) is the most common form of human genetic variations, which are significantly linked to the risk of tumorigenesis. It was reported that the polymorphisms in rs3783553, rs3783550, rs3783546, rs1609682 and rs3783521 of IL-1α ( 138 , 139 ), rs1524107 and rs2066992 of IL-6 ( 140 ), rs4758680 and rs7977932 of IL-31 ( 141 ), rs28372698 and rs12934561 of IL-32 ( 2 ) may be relevant to increased susceptibility to EC in Chinese women. Moreover, the CC genotype of IL-6 Gene (−174 & -572) might contribute to EC risk ( 142 ).…”

Section: Clinical Application Of Interleukins In Ecmentioning

confidence: 99%

The roles and clinical applications of interleukins in endometrial carcinoma

Zang

Liu

et al. 2022

Front. Oncol.

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As a common malignant tumor of the female reproductive system, endometrial carcinoma (EC) seriously endangers women’s health with an increasing incidence. The oncogenesis and progression of cancer are closely linked with immune microenvironment, of which interleukins are the important components. In order to illustrate the roles and clinical applications of interleukins in EC, literature of interleukins and EC were reviewed. Based on the present studies, interleukins play crucial roles in the oncogenesis and development of EC via regulating the proliferation, migration, invasion, angiogenesis, apoptosis, pyroptosis and autophagy of EC as well as the immune function against EC. And some of the interleukins seems to have prospective clinical applications in EC, such as evaluating the risk of tumorigenesis, discriminating the malignancy from benign disorders or normal condition, indicating cancer aggressiveness, predicting the prognosis of patients and serving as the novel therapy. However, there is still a long way to go before the clinical applications of interleukins in EC come into reality. Nevertheless, it is certain that the exploration of interleukins will definitely be of great benefit to the screening, diagnosis and treatment of EC in the future.

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“…According to the latest cancer statistics reported in the United States in 2020, EC has ranked the fourth of newly diagnosed cases of female malignant tumor ( 2 ). In many economically developed areas of China, EC has become the most common malignant tumor of female reproductive system, and the incidence is increasing year by year, such as Beijing, Shanghai, and Guangzhou ( 3 ). Studies have reported that most patients with EC are diagnosed at the early stage (80% of stage I patients), and the 5-year survival rate could reach 95%.…”

Section: Introductionmentioning

confidence: 99%

Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding

Wang,

Quan,

Bai

et al. 2024

Front. Oncol.

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ObjectiveEarly detection and diagnosis are important for improving the therapeutic effect and quality of life in patients with endometrial cancer (EC). This study aimed to analyze the clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding (AUB) in order to provide evidence for the prevention and early diagnosis of EC.MethodsA total of 462 perimenopausal women with AUB were enrolled in this prospective observational study. Endometrial biopsy was performed in patients with suspected endometrial lesions. According to the pathological examination results, the patients were divided into endometrial polyp group (EP) (n = 71), endometrial hyperplasia without atypia group (EH) (n = 59), atypical endometrial hyperplasia (AEH) (n = 36), and EC group (n = 27). The history risk factors and ultrasonic imaging characteristics of endometrium among the four groups were compared.ResultsTwenty-seven women were diagnosed with EC (5.84%). The prevalence rate of AEH and EC in the group of 51- to 55-year-old women was significantly higher than that in the groups of 40- to 45-year-old women and of 46- to 50-year-old women (P < 0.05). The age, body mass index, and history of diabetes gradually increased with the development of endometrial pathological types. In addition, the correlation index of endometrial blood flow increased gradually, and the proportion of uneven endometrial echo, unclear endometrial–myometrial junction (EMJ), and ovarian cyst also increased gradually. However, no statistically significant difference was found when comparing endometrial thickness (ET) and endometrial volume (EV) among endometrial pathological groups (P > 0.05). The ET, EV, endometrial vascularization index, endometrial flow index, and vascularization flow index in the ovarian cyst group were significantly higher (P < 0.05), and the proportion of uneven endometrium echo and unclear EMJ were significantly higher compared with that in the non-ovarian cyst group (P < 0.05).ConclusionsThe most common cause of perimenopausal women with AUB was benign endometrial lesions. However, women aged 51–55 years old with endometrial high risk factors and ovarian cyst should be alert to AEH and EC. Endometrial biopsy needs to be performed to determine endometrial malignancy in necessity.

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Polymorphisms in IL‐1A are associated with endometrial cancer susceptibility among Chinese Han population: A case–control study

Cited by 7 publications

References 26 publications

Association between gene polymorphisms of IL‐12, IL‐12 receptor and IL‐27 and organ involvement in Iranian endometriosis patients

Association between gene polymorphisms of IL‐12, IL‐12 receptor and IL‐27 and organ involvement in Iranian endometriosis patients

The roles and clinical applications of interleukins in endometrial carcinoma

Analysis of clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding

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