Polymorphisms in the 5-HTR2A gene related to obstructive sleep apnea syndrome

Abstract

Obstructive sleep apnea syndrome (OSAS) is one of the most complex disorders of sleep; it involves several genetic factors that contribute to the phenotype. Serotonin (5-HT) regulates a variety of visceral and physiological functions, including sleep. Gene 5-HTR2A polymorphisms may change the transcription of several receptors in the serotoninergic system, thereby contributing to OSAS. Aim To investigate the prevalence of T102C and -1438G/A polymorphisms in the 5-HTR2A gene of patients with and without OSAS. Material and Method A molecular study of 100 index-cases and 100 controls of both genders. DNA was extracted from blood leukocytes samples and the regions that enclose both polymorphisms were amplified with PCR-RFLP. Study design A cross-sectional case study. Results There was a significant prevalence of males in index cases compared to controls (p<0.0001). No significant genotypic differences between cases and controls were found in T102C polymorphisms ( p =1.000). There were significant differences between the AA genotype of -1438G/A polymorphisms and patients with OSAS (OR:2.3; CI95%:1.20-4.38, p =0.01). Conclusion Serotonergic mechanisms may be related to OSAS. There were no differences in the prevalence of T102C polymorphisms in patients with OSAS and the control group. There is evidence of an association between the -1438G/A polymorphism and OSAS.

Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19

“…ARL6IP6 (MIM 616495) is an ADP-Ribosylation-Like Factor 6 Interacting Protein 6, associated with ischemic stroke [ 27 ]. HTR2A (MIM 18135) is a Serotonin 5-HT-2A Receptor with effects on sleep quality [ 28 ]. Reduction of TRPM3 (MIM 608961) is described to be associated with chronic fatigue syndrome/Myalgic encephalomyelitis patients [ 29 ], and FGF2 (MIM 134920) has been proposed to play a role in intussusceptive angiogenesis during COVID-19 [ 30 ].…”

Relationship between rosacea and sleep

“…In our present study, SNP related to sleep, including HTR2A and ADRB1, were first detected. HTR2A is one of the central nervous system neurotransmitters involved in regulating physiological functions, including sleep 62 . Its polymorphisms were found to be significantly associated with increased risk of poor sleep quality in previous studies 32,33,62–64 .…”

“…HTR2A is one of the central nervous system neurotransmitters involved in regulating physiological functions, including sleep 62 . Its polymorphisms were found to be significantly associated with increased risk of poor sleep quality in previous studies 32,33,62–64 . ADRB1 is also involved in the regulation of circadian sleep 65–68 .…”

Target identification among known drugs by deep learning from heterogeneous networks

“…31 Multiple polymorphisms in HTR2A, HTR1A, HTR2B, and HTR3C were identied in patients with high blood pressure, 32,33 metabolic syndrome, 32 and obstructive sleep apnea. 34 Via deepDTnet, we computationally identify several validated off-targets for alosetron and tegaserod (Table S6 †), which may help explain the molecular mechanisms of several adverse effects, such as sleep disorder and angina pectoris (Fig. 4B).…”