Polymorphisms in the ALOX12 gene and osteoporosis

Abstract

Our study suggests that genetic variants in ALOX12 may influence BMD and fracture risk.

Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography

“…Osteoporosis is caused by a bone remodeling disturbance in which bone resorption exceeds bone formation [16]. Whereas trabecular bone is severely affected already after few years (around 6) in AN patients, in postmenopausal women a similar break-down occurs over a longer time span (around 25 years).…”

Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families

“…Therefore, our results should be interpreted cautiously, and further studies should be conducted to determine the strength of these associations in various populations. However, our previous study [33] found no association between rs312470 or the other four SNPs from ALOX12 and peak BMD in Chinese nuclear families with male offspring. This finding raised the possibility of a sexspecific association of ALOX12 with the BMD [12,34].…”

“…Recently, Pratico et al [40] suggested that the ALOX12 levels and activity in the frontal and temporal regions of brains exhibiting Alzheimer's disease are significantly increased. Our previous study [33] found a significant association between the rs2073438 SNP in the ALOX12 gene and the total fat mass (TFM) and total lean mass (TLM) in a QTDT study of Chinese nuclear family with male offspring, suggesting this SNP's involvement in the variation of the obesity phenotype, perhaps through a PPARγ-dependent pathway.…”

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

“…The rationale for SNP selection at the time when genotyping was performed is outlined below. SNPs for ALOX12 were selected from the literature as having been previously investigated for BMD [16,18,20]. SNP rs312466…”

“…is located in the promoter, while rs1126667 and rs2292350 are NCBI tagging SNPs located in an LD block [16]. For ALOX15, with the exception of rs8074545 upstream of the coding region (which is intergenic and therefore has potential functionality) all selected SNPs were tagging SNPs previously investigated for BMD (rs748694; rs9894225; rs916055; rs2619112) [20].…”